Misamore's Lecture

Front 1

There are four types of tissues:

Back 1

Epithelial
Connective
Muscle
Nervous

Front 2

Definition of tissue

Back 2

Tissue is a group of cells working together for a common function

Front 3

Examples of connective tissue

Back 3

blood, bone, cartilage, and dermis underneath your skin

Front 4

Tissue has two major components

Back 4

Cells ans extracellular matrix

Front 5

Epithelial tissue.
Characteristics

Back 5

Cell always touch. No much extracellular matrix.

Front 6

In the epithelial tissue, strength comes from ______

Back 6

cytoskeleton

Front 7

In the connective tissue, strength comes from _______

Back 7

Extracellular Matrix

Front 8

Types of cell junctions

Back 8

Anchoring junctions
Occluding junctions
Channel Forming Junctions
Signal Relaying

Front 9

Anchoring cell junction

Back 9

It hold cells to each other in the tissue

Front 10

Occluding junction

Back 10

It occlude things from passing

Front 11

Anchoring junction is btw cell to cell
There are two main groups of anchoring junctions:

Back 11

Cell-Cell
Cell-ECM

Front 12

Types of anchoring junctions

Back 12

Actin filament attachment sites
a) cell-cell junctions (adherens junctions)
b) cell-matrix junctions (actin-linked-cell-matrix adhesions)
Intermediate filament attachment sites
a) cell-cell junctions (desmosomes)
b) cell-matrix junctions (hemidesmosomes)

Front 13

In the epithelial tissue, strength comes from ______

Back 13

cytoskeleton

Front 14

In the connective tissue, strength comes from _______

Back 14

Extracellular Matrix

Front 15

Types of cell junctions

Back 15

Anchoring junctions
Occluding junctions
Channel Forming Junctions
Signal Relaying

Front 16

Anchoring cell junction

Back 16

It hold cells to each other in the tissue

Front 17

Occluding junction

Back 17

It occlude things from passing

Front 18

Anchoring junction is btw cell to cell
There are two main groups of anchoring junctions:

Back 18

Cell-Cell
Cell-ECM

Front 19

Types of anchoring junctions

Back 19

Actin filament attachment sites
a) cell-cell junctions (adherens junctions)
b) cell-matrix junctions (actin-linked-cell-matrix adhesions)
Intermediate filament attachment sites
a) cell-cell junctions (desmosomes)
b) cell-matrix junctions (hemidesmosomes)

Front 20

In the epithelial tissue, strength comes from ______

Back 20

cytoskeleton

Front 21

In the connective tissue, strength comes from _______

Back 21

Extracellular Matrix

Front 22

Types of cell junctions

Back 22

Anchoring junctions
Occluding junctions
Channel Forming Junctions
Signal Relaying

Front 23

Anchoring cell junction

Back 23

It hold cells to each other in the tissue

Front 24

Occluding junction

Back 24

It occlude things from passing

Front 25

Anchoring junction is btw cell to cell
There are two main groups of anchoring junctions:

Back 25

Cell-Cell
Cell-ECM

Front 26

Types of anchoring junctions

Back 26

Actin filament attachment sites
a) cell-cell junctions (adherens junctions)
b) cell-matrix junctions (actin-linked-cell-matrix adhesions)
Intermediate filament attachment sites
a) cell-cell junctions (desmosomes)
b) cell-matrix junctions (hemidesmosomes)

Front 27

Desmosome
Transmembrane adhesin protein

Back 27

Cadherin (desmoglein, desmocollin)

Front 28

Desmosome
Extracellular ligand

Back 28

desmoglein and desmocollin in neighboring cell

Front 29

Desmosome
Intracellular cytoskeletal attachment

Back 29

intermediate filaments

Front 30

Desmosome
Intracellular anchor proteins

Back 30

plakoglobin, plakophilin, desmoplakin

Front 31

Actin-linked cell-matrix adhesion
Transmembrane protein

Back 31

integrin

Front 32

Actin-Linked cell-matrix adhesion
Extracellular ligand

Back 32

extracellular matrix proteins

Front 33

Actin-Linked cell-matrix adhesion
Intracellular Cytoskeletal attachment

Back 33

actin filaments

Front 34

Actin-Linked cell-matrix adhesion
Intracellular anchor proteins

Back 34

talin, vinculin, alpha actinin, filamin, paxillin, focal adhesion kinase (FAK)

Front 35

Hemidesmosome
Transmembrane adhesion protein

Back 35

Integrin

Front 36

Hemidesmosome
Extracellular ligand

Back 36

extracellular matrix proteins

Front 37

Hemidesmosome
Intracellular cytoskeletal attachment

Back 37

intermediate filaments

Front 38

Hemidesmosome
Intracellular anchor proteins

Back 38

plectin, dystonin (BP230)

Front 39

Cell to Cell Anchoring Junctions
Two types:

Back 39

Zonula Adherens or adherens junctions
Desmosomes

Front 40

Zonula adherins

Back 40

They are connected to by a family of adherins. The family is called cadherin. Cadherins are transmembrane proteins. They expand space btw cells and link the cytoskeleton of the cells to actin. This linkage is done by anchor proteins.

Front 41

Proteins that link cadherin to actin are:

Back 41

p120, beta catenin, and other anchor proteins.
These proteins are very important for the regulation of adhesions.

Front 42

Desmosomes
Transmembrane proteins:

Back 42

Desmoglein and desmocollin

Front 43

Pemphigus

Back 43

It is a disease. When you disrupt the linkage of the proteins to the intermediate filaments. Therefore, desmosomes are disrupted.

Front 44

Cell to ECM Anchoring junctions
Two types

Back 44

Focal adhesion (actin)
Hemidesmosomes (intermediate filaments)