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6 Cards in this Set

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Name the conditions most often associated with C. perfringens.
Myonecrosis(gas gangrene) cellulitis, food poisoning, necrotizing enteritis.
Name two major toxins by C. perfringens.
Alpha toxin(lecithinase) and enterotoxin(heat labile toxin)
What is the role of alpha toxin in myonecrosis?
Alpha toxin lyses red blood cells, endothelial cells, leukocytes and platelets. This facilitates invasion of muscles near the infected wounds, leading to the production of subcutaneous gas(gas gangrene)
How is gas gangrene treated?
Surgical debridement of necrotic tissue, antibiotics(penicillin plus clindamycin) and hyperbaric O2 chamber may disrupt anerobic progression of myonecrosis.
How does C. perfringens food poisoning usually present?
Abdominal cramps, diarrhea and fever that presents 8-18 hrs after ingestion of contaminated beef, poultry, pork and fish. It takes more time than S. aureus to develop symptoms because C. perfringens has to grow and produce enterotoxin in vivo.
How is C. perfringens food poisoning treated?
Supportive care treatment because it is a self limiting disease.