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44 Cards in this Set
- Front
- Back
Ferments mannitol, produces hemolysins and DNAase
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Staphylococcus aureus
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Diabetics and drug addicts have a much higher rate of colonization of this bacteria
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Staphylococcus aureus
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Epidemic outbreaks of this bacteria can be traced by several methods, including serological, phage typing, DNA fingerprinting, ribotyping, and DNA sequencing of selected genes such as protein A and coagulase among different strains
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Staphylococcus aureus
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This bacteria has a phage receptor that is useful for typing purposes in outbreaks
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Staphylococcus aureus
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This genus of bacteria is 60% resistant to methicillin
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Staphylococci
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This genus of bacteria is the major cause of hospital-related bacteremias in the US
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Staphylococci
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Toxin mediated disease of Staph. aureus that does not require colonization by the bacteria
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Food poisoning (food borne diarrhea); contamination of food or tampon by toxin
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Toxin mediated disease of Staph. aureus that requires colonization followed by toxin production
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TSS, scalded-skin syndrome
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This bacteria synthesizes multiple surface adhesive molecules that bind to the host cellular matrix proteins found on damaged skin, disrupted airway epithelium, or endothelial cell walls within the bloodstream (fibrinogen, fibronectin, colleage, platelets, etc.)
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Staph. aureus
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Cause of food poisoning by Staphylococcus aureus
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Enterotoxins A through I, excluding F, of S. aureus (enterotoxin F is TSST-1)
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This bacteria secretes numerous toxins and enzymes that can cause host cell lysis
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Staph. aureus
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Protein A
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Cell wall protein found in S. aureus that binds to host IgG via the Fc receptor, inhibiting complement-mediated killing.
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This is a B-cell superantigen that leads to defective production of specific IgM
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Protein A
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These are T-cell superantigens the blunt specific host T-cell response
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Enterotoxins A through I, excluding F, of S. aureus (enterotoxin F is TSST-1)
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This enzyme clots human or rabbit plasma by activating fibrinogen (by first activating thrombin)
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Coagulase, found in Staphylococcus aureus
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Eap (Map)
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Surface protein of S. aureus that impairs neutrophil recruitment
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Superantigens stimulate secretion of these cytokines
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IL-1, IL-2, TNF
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Mupirocin
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Used intranasally to prevent nasal colonization of Staphylococcus aureus
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T/F: Diarrhea caused by enterotoxin of S. aureus is often bloody
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False. It causes nausea, vomiting and non-bloody diarrhea
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EtaA, EtaB
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Exfoliatin toxins secreted by phage group II S. aureus; the cause of SSSS
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Phage group II Staphylococcus aureus
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Cause scalded-skin syndrome
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This disease is usually seen in infants, characterized by erythematous skin followed by peeling
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Staphylococcal scalded-skin syndrome
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This disease is commonly associated with tampon use, patients with wound infects, or patients with nasal packing
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Toxic shock syndrome (Staph aureus)
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Antibiotics are not helpful in these diseases because many of the syndromes are immunological
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Toxin-mediated syndromes of Staph aureus
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Deep-seated infections that can be caused by S aureus
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Pneumonia, endocarditis, osteomyelitis, arthritis, abscess (liver, spleen, kidney, brain), meningitis, sepsis
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This bacteria can cause hematogenous arthritis, especially in children
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Staphylococcus aureus
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Semisynthetic penicillin
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Used to treat Staphylococcus aureus--penicillinase renders them resistant to regular penicillin but not synthetic penicillin
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Dicloxacillin
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Oral semisynthetic penicillin
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Oxacillin
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Intravenous semisynthetic penicillin
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Coagulase negative Staphylococci
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Epidermidis, saprophyticus
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T/F: S. epidermidis forms white colonies that are larger than the colonies of S. aureus
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False. Colonies are smaller.
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This bacteria shows very little hemolysis on blood agar plate
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Staphylococcus epidermidis
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These bacteria can be distinguished from each other by testing for mannitol fermentation
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Staphylococci. Only aureus ferments mannitol
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These bacteria are notable for colonizing IV catheters
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Staphylococci aurues and epidermidis
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This bacteria can colonize prosthetic surfaces very efficiently
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Staph epidermidis
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This bacteria can proliferate and invade bloodstream, but much more slowly than Staph aureus
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Staph epidermidis
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Attachment of Staphylococcus epidermidis to synthetic surfaces (to form a biofilm) is mediated by this
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Surface carbohydrates
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This bacteria is resistant to semisynthestic penicillin; treat with vancomycin
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Staph epidermidis
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Clinical course of infection by this bacteria is generally indolent
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Staph epidermidis (eg, infected prosthetic device)
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These bacteria are distinguished from each other by resistance to novobiocin
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Staphylococcus epidermidis and saprophyticus
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This bacteria causes UTI's in young women, second only to E. coli
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Staph saprophyticus
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Treatment for S aureus infections
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Semisynthetic penicillin; vancomycin as last resort
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Treatment for S saprophyticus infections
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Trimethoprim (Bactrim), quinolone (norfloxacin)
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Treatment for S epidermidis infections
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Vancomycin; if toxin, add rifampin and/or gentimicin
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