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237 Cards in this Set
- Front
- Back
Staph aureus color, Staph epidermidis color
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yellow, white
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S aureus virulence factors
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Protein A, teichoic acid (adherence), Capsule (inhibits phagocytosis)
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S aureus penicillin resistance?
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yes
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S aureus preferentially colonizes the ?
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nares
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For culturing staph, what is a nonselective media, and a selective media?
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sheep blood and chocolate agar are none selective, mannitol salt agar is selective
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Strep mode of metabolism?
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Oxygen tolerant anaerobic
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Strep A, hemolysis, bacitracin, pyrase,
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Beta, sensitive, positive (red)
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Pneumonia
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lecture
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Most common causitive agent
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Bacterial
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pathophysiology, 4 steps
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1. Infection of lung parenchyma by organism
2. Neutrophils migrate: pulm capiliaries alveolar spaces 3. Neutrophils phagocytose & kill injested microbe 4. Inflammation neutrophilic exudate in alveolar spaces – prevents O2 exchange (SOB) |
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Most common cause of pneumonia
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S. pneumoniae
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X-ray finding for inhalation of anthrax
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wide mediastinum
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S. pneumoniae penicillin resistence?
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yes
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Strain associated with COPD and alcoholism
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Hemophilus influenzae (penicillin resistant)
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Describe Hib vaccine
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Conjugate vaccine w/Type B polysacch
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Aspiration pneumonia, Abscess in lungs, Alcoholics, diAbetics” think....
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Klebsiella pneumoniae
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CXR presentation of Klebsiella
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CRX: upper lobe w/bulging fissure – classic presentation
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Sputum in Klebsiella
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red curant jelly
|
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This bacteria commonly follows H. Influenzae
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S. aureus
Staphylococcal Pneumonia |
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Pneumonia with high fevers and fiegets sign think....
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Legionella
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CXR appears worse then symptoms, walking pneumonia think....
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Mycoplasma pneumoniae
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Pneumonia in college students think....
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Chlamydophilia
Pneumoniae |
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Are the majority of bacteria in aspiration pneumonia anaerobic or aerobic.
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ANaerobic AspiratioN
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Nosocomial pneumonia is due to _____ gram ____ bacteria
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aerobic gram negative
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Characteristics of empyema
pH, glucose, gram stain, ldh |
low ph, low glucose, gram positive, high ldh
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Neisseria mode of metabolism and appearance
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aerobic gram negative diplococci
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Confirmation of the presence of Neisseria is based on a series of ________ fermentations
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carbohydrate
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Serogroups of N. Menigintidis based on
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capsular polysacchiride
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Serotypes based on
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outer membrane protein
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Only bacterial meningitis associated with epidemics?
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Meningococcal Meningitis
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Most cases are due to which serogroup
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b
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Most cases of meningitus are caused by
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strep pneumoniae, most common cause of adult menigitis
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petechial rash think....
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Meningococcemia
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Clinical manifestations of Meningococcemia
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aprehension, delirium, rapid progression, shock, high mortality
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Neck stiffness think...
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meningitis in adults, young children may only have fever and vomiting
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Classic medium for culturing Neisseria is?
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Thayer-Martin, chocolate agar with antibiotics that kill competing bacteria.
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Treat Neiserria meningitidis with
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cephalosporins
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Who gets meningococcal chemoprophylaxis?
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only those that come into close contact, give rifampin, ceftriaxone, or cipro
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Function of por protein (1) in N. Gonorrhoaea
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prevents phagolysosome fusion in neutrophils
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Function of Opa Protein (2)
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mediates attachment to epithelial cells and invasion into cells
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Function of lactoferrin binding protein
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abstracts iron
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Pathogenesis of N. Gonorrhoae
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ciliary stasis
death of ciliated cells attachment internalization intracellular replication intracellular traffic exocytosis |
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N. Gonorrhoae infection in men restricted to
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urethra
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N. Gonorrhoae infection in women restricted to
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cervix
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Pustular skin lesion think
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N. Gonorrhoae
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N. Gonorrhoae treatment
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ceftriaxone
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Moraxella commonly seen in patients with?
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COPD
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Otitis media and Sinunitus think?
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Moraxella catarrhalis
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Treament of Moraxella
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very resistant, use broad spectrum
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- Lactose fermenters
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SCEEK
Serratia, Cirobacter, E. coli, Enterobacter, Klebsiella Salmonella, Shigella & Pseudomonas aeruginosa DO NOT |
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- MacConkey Agar
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- Lactose fermentors RED – colonies are red at low pH
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Enterobacteriacea generalities
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-Doesn’t cause sore-throat
-Think COFFEe Capsular O antigen – polysach. of endotoxin Flagellar antigen Ferment glucose Enterobacteriacae |
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Most common cause of UTI, and travelers diarrhea (adults)
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E-Coli
|
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Pneumonia – debilitated PTs
(Red currant jelly sputum cavitary), think |
Klebsiella
|
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Bright Red Pigment produced by prodigiosin think
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Serratia (Lactose fermentor (SCEEK)
slow fermentor) -Model: airborne dissemination of bioterrorism -Can survive some disinfectants & non-bacterial soaps; related to outbreaks |
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Plague (bubonic, septicemic, and pnemonic)
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Yersinia Pestis
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OUTBREAK: blood bank, chocolate milk
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Yersinia Enterocolitica
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Yersinia staining uniqueness?
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bipolar staining
|
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ONLY seen in hospital think...
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Acinetobacter
|
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-Most frequent wound infection following cat/dog bite/scratch think...
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Pasteurella mulocida
|
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Outbreaks cruise ships (japan) think....
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Vibrios parahaemolyticus
|
|
leeches think...
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Aeromonas
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New Orleans, oysters – alcoholics (cirrhosis ) think...
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v. vulnificus, rapidly progressive cellulitis with bacteremia, abrupt onset fevors, high mortality
|
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Unpasteurized milk, Undulant fever, feral pigs, animal workers think
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Brucellosis
|
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Where does Brucellosis live and multiply?
|
Facultative intracellular parasite – multiplies in macrophages. (requires cell-mediated immunity to control), first infects lymph nodes, disseminates to liver, spleen, kidney
|
|
Transmitted via cat flea, Bacillary angiomatosis, think
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Bartonella henselae
|
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Trench fever think
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Bartonella Quintana
|
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Andes mountains, Oroya Fever,
Bacteria penetrate RBCs (like malaria) – Carrion’s Disease: Bi-phasic -Acute: Fever, myalgia, headache -Chronic: Verruga peruana (cutaneous nodules) after 1-2 mos; may persist for yrs |
Bartonella baciiliformis
|
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Psedomonas aeruginosa
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Simon
|
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Metabolism, fermentation? oxidase? pyocynanin?
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-Gram (–) Bacillus
-Nonsporulating -Obligate aerobe except w/nitrate. -Non-fermentor -Oxidase (+) – has cyt oxidase a3. -Pyocyanin blue-green |
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“Be Pseudo"
|
Burns
Endocarditis (IVDA) Pneumonia (CF) Sepsis (↑mortality) External Otitis (malignant) UTI Diabetics get.. Osteomyletis |
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#2 nosocomial pathogen
|
Pseduomonas, #1 is E.Coli
|
|
4 predisposing factors,
|
immunosupression, icu, cystic fibrosis, prolonged hospitalization
|
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Colinization
|
found on skin, moist environments
|
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Function of exotoxin A
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inhibits protein syn. (ADP ribosylation of EF-2
|
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Function of exoenzyme S
|
: inhibits proteins syn.; promotes dissemination (tissues
|
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What allows it to produce reactive oxygen species?
|
pyocyanin
|
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How does it protect itself from radicals
|
superoxide dismutase
|
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lesions on butt?
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Whirl Pool Folliculitis
|
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Neutropenic Cancer PTs are prone to?
SPEK |
E. Coli
Klebsiella Pseudomonas S. Arueas |
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-Endocarditis in IV drug users (Detroit). think....
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Think Psuedo
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Uti Predisposing factors 4
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anatomic (short urethra), sex, foley cathetars, nosocomial
|
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most abundant protein in urine: binds E. Coli and prevents epithelial cell attachment.
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Tamm-Horsfall protein
|
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: recognizes bacterial polysaccharides; abundantly expressed in bladder & kidney
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TLR11
|
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most common route of infection, ascending or descending
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ascending is most common: rectal flora perineal colonization vaginal colonization introital colonization urethra bladder ( kidney).
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introital colonization is associated with?
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vaginal pH, & ↑’d w/antibiotics (esp β-lactams).
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Community aquired UTI is most likely
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Ecoli or Saprophyticus
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Hospital aquired UTI is most likely
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Pseudomonas
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Is preexisting antibody to a UTI infection preventative?
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-pre-existing Ab to the infecting org is NOT protective, immune system has little role in UTIs: NO increased incidence of UTIs in patients w/humoral or cellular immune deficiencies
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Most correlated with antibody response, upper tract or lower tract infection?
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upper
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WBC casts think...
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pyelonephritis upper tract
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What bacteria causes renal failure?
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bacterial infections don’t cause renal failure unless there is an obstruction.
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Who should not be treated for asymtomatic bacteruria
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don’t treat in adults (esp elderly) b/c tx associated w/higher mortality, treat in pregnant women and kids
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T/F ALL UTIs are ANATOMICAL
|
T
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Acute Bacterial Prostatitus most commonly caused by
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E.Coli
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Prostatitis symptoms
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fever, bank pain, chills
|
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appearance of prostate
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warm, swollen, tender
|
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T/F you should massage a prostate that is inflammed.
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NO PROSTATE MASSAGE
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How is chronic prostatitus different from acute?
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non-bacterial
may be asymptomatic massage may be done |
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Problems with Prostate treatment
|
hard to penetrate prostate, treat for 3 weeks.
|
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Fever
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Fever
|
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Signals received by the pre-optic nucleus are sent from the _____ hypothalamus to the _____ hypothalamus – location of the hypothalamic set point
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anterior to posterior
|
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example of a pyrogen
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LPS
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example of endogenous pyrogen 3
|
Il-1, TNFa, IFNg
|
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normal fever range
|
35.6 – 38.2
|
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two pathways to fever
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1) IL-1 ant hypothalmus, protaglandins, post hypothalmust, change set point
2)local inflammation, thermosensitive neurons, signal to ant hypothalus |
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In what situation is it better to treat the fever over the infection
|
if a cns injury is present
|
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Fever of unknown origin
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> 3 weeks of fever (>38.4oC)
Infection most common cause Avoid “therapeutic” trials of antibiotics Make a diagnosis first |
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Acetaminophen in children may promote
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Reyes syndrome
|
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_
|
_
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|
_
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_
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Sepsis
|
Sepsi
|
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Define Bacteremia
|
bacteria in blood (bad)
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Define Sepsis
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Bacteremia PLUS signs of systemic inflammatory response
Fever, tachycardia, hypotension, etc |
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Define Septic Shock
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Sepsis PLUS signs of end-organ hypoperfusion
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Septic shock more likely to be cause by Gram- or Gram+
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Gram Negative
|
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Sepsis caused mostly by Gram- or Gram+
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Gram +, Used to be Gram -
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Most common cause of bacteremia?
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Ecoli
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Most common cause of death due to bacteremia is caused by what organism?
|
Psuedo due to debilitated host
|
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the TWO MAIN mediators of the pro-inflammatory response in sepsis.
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Interleukin-1 (IL-1)
Tumor necrosis factor-α (TNFα) |
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Toxins that cause sepsis similar to LPS are known as?
|
Superantigens
|
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D-dimers are markers for what process?
|
DIC
|
|
DIC is treated with?
|
anticoagulative factors
|
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Describe the anti-inflammatory response seen in sepsis
|
Shift from a Th1 to a Th2 response to infection
See apoptosis of lymphocytes and secondary infection due to immunosuppresion |
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Clinical Manifestations of Shock on cardiovascular system 4
|
reduced tpr
Compensatory increase in cardiac output Direct suppressive effect of LPS on myocardial contractility Shock results when heart cannot compensate for reduced SVR |
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Shocks effect on respiratory system
|
Acute Respiratory Distress syndrome which is caused by increased microvascular permeability
|
|
What is an anticoagulant used to treat sepsis?
|
Protein C
|
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A prime function of IL-1 and TNFα
|
up-regulate adhesion molecules in neutrophils and endothelial cells and cause their activation
|
|
upregulation of this stimulates coagulation
|
tissue factor
|
|
Gram negative most common site of infection
|
UTI
|
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Organs most affected by hypotension in order from first to last
|
Hypotension first hits the kidneys, then the lungs, then the gut, then the heart, brain
|
|
What Interlekins shift TH1 to TH2
|
Il-6 and Il-10
|
|
Most common bug acute endocarditus
|
Staphylococcus aureus most common bug
|
|
Most common bug subacute endocarditus
|
Viridans Streptococci
|
|
Endocarditus pathogenesis, 2 steps
|
non-bacterial thrombotic endocartitus, transient bacteremia
|
|
Strep. bovis: think....
|
Colon Cancer
|
|
Prosthetic valve endocarditis causes, 2, one is early, one is late
|
Early (<60 days post-surgery): S. aureus, CNS
Late: viridans Streptococci |
|
Valve commonly effected in IV drug uses?
|
tricupsid (right heart)
|
|
IV drug users are susceptible to what bacteria? 2
|
s. aureus, pseudo
|
|
Classic presentation of endocarditis
|
fever, anemia, changing murmor
|
|
Peripheral Manifestations of Endocarditis beginning with, C,S,O,J,R
|
Conjunctival petecchiae
Splinter hemorrhages: nail beds Osler’s nodes: painful nodules on pads of fingers and toes Immune complex vasculitis Janeway lesions: non-tender erythematous macules on palms and soles Micro-abscesses Roth’s spots: retinal hemorrhages Immune complex vasculitis |
|
Three lab finding in endocarditis beginning, A,T,M
|
Anemia
Thrombocytopenia Microscopic hematuria |
|
Echocardiogram with more sensitiviy for detecting endocarditis
|
Transesophageal (TEE) has higher sensitivity than transthoracic (TTE) therefore is preferred
|
|
Two categories of people that should be given antibiotic prophylaxis for endocarditis
|
those having dental procedures,
and Give to high risk ONLY: Prior endocarditis Prosthetic valve Heart transplant with valve abnormalities Complicated congenital heart disease |
|
What time should surgery be performed in a patient with endocarditis that requires surgery?
|
ASAP
|
|
-
|
-
|
|
-
|
-
|
|
Gram Positive Rods
|
Gram Positive Rods
|
|
Bacillus antracis spore forming or non spore forming
|
spores
|
|
Three virulence factors of anthrax
|
lethal toxin, edema toxin, capsule
|
|
CXR or anthrax
|
wide mediastinum
|
|
Clinical phases of Respiratory Anthrax
|
initial 1-3 days - maliaise
secondary 1-2days, sudden progression to death |
|
Two types of GI Anthrax
|
abdominal and oropharnygeal
|
|
Best way to control antrax
|
controll it in animals first
|
|
Bacillus cereus spore forming, or non spore forming
|
spore forming
|
|
Rice contaminated with bacteria think
|
Bacillus ceres
|
|
Two types of B. Cereus food poisoning
|
Emetic and Diarrheal
|
|
C. diptheriae shape on gram stain
|
club shaped
|
|
C. diptheriae transmission
|
airborne droplets, colder months, crowded conditions
|
|
C. diptheriae produces inflammation first in what location
|
exudate in pharynx/trachea
|
|
Soft tissue of neck swells, called a bull neck.... think
|
C. diptheriae
|
|
describe C. diptheriae exudate
|
tough, leathery, grey
|
|
C. diptheriae will travel two places after setting up camp in the pharynx
|
cardiac toxicity, neurologic toxicity
|
|
Listeria monocytogenes mode of transmission
|
veritical
|
|
Population at risk for Listeria monocytogenes
|
old, young, pregnant, immunosuprresed
|
|
Listeria monocytogenes incubation period
|
11-70 days
|
|
Listeria monocytogenes is enhaced by what medication
|
H2 blockers
|
|
Listeria monocytogenes lives
|
intracelluarlly
|
|
What is Granulomatosis Infantiseptica and what causes it
|
Listeria monocytogenes, granulomas in infants
|
|
Swine worker, skin lesion, diffuse rash, endocarditus think....
|
Erysipelothrix
|
|
95% of anthrax infections are of what manifestation
|
cutaneous
|
|
Bacillus ocular infections are caused by antracis or cereus, and what patient population is at risk
|
cereus, IV drug users
|
|
Bacillus Cereus rice causes
|
emetic food posinening
|
|
Bacillus Cereus meats or vegetables cause
|
diarrheal food posinening
|
|
C. Diptheriae rods are shapped like?
|
clubs, chinese characters
|
|
C. Diptheriae transmission takes place via?
|
airborne droplets
|
|
Listeria Mono horizontal transmission occurs via
|
zoonosis, unpasterized milk
|
|
Listeria Mono lives inside what type of cell?
|
Macrophages
|
|
Mycoplasma P. pathogenesis
|
affinity for epithelium, contributes to loss of cillia from host
|
|
Mycoplasma and Ureaplasma appearance on agar
|
fried egg, except Mycoplasma P. which has a mulberry appearance
|
|
Mycoplasma P. is spread via
|
aerolized droplets, single cases or mini epidemics are common
|
|
Mycoplasma P. two clinical presentations
|
Tracheobronchitis and atypical pneumonia
|
|
Mycoplasma P. feature that may distinguish it from other atypical pnuemonias
|
bullous myringitis
|
|
What is responsilbe for causing Raynauds Phenomenon in Mycoplasma P.
|
cold agglutinins
|
|
Chlamydia morphology
|
gram negative, intracelluar
|
|
Chlamydia form that is infectious
|
elementary body
|
|
Chlamydia form that replictates
|
reticulate body
|
|
Chlamydia trachomatis clinical manifestations,
|
Urethritis/Cervicits
Lymphogranuloma venerum ocular infection |
|
Chlamydia trach infects what type of cells
|
non-cilliated columnar epithelial cells
|
|
birds are natural resovior, pneumonitis think
|
Chlamydia psittaci
|
|
Bordetella Pertussis transmitted via
|
inhalation of aerolized bacteria
|
|
Bordetella Pertussis attached to what cells
|
cilliated epithelial cells of the bronchial tree
|
|
3 viruluence factors of Bordetella Pertussis
|
Filamentous hemagglutin - blocks phagocytosis, binds to cillia
Pertussis toxin - increases mucus secretion, prometes leukocytosis, Bacterial pili/pertactin - attachment of bacteria to respiratory epithelium |
|
4 stages of Bordetella Pertussis
|
incubation 7-21 days
catarrhal 1-2wks malaise paroxsymal 2-4 weeks whoop convalescent month pneumonia/cns |
|
Bordetella Pertussis main cause of mortality
|
complication from aspiration pnemonia
|
|
Haemophilus influenzae growth requires what 2 supplements
|
x factor and v factor
|
|
HIB vaccine is made against what strain of Haemophilus influenzae
|
B type capsule
|
|
Haemophilus influenzae transmission occurs via
|
contact secretions or airborne droplets
|
|
Haemophilus influenzae virulence factors 4
|
capsule
LPS Outer membrane proteins - iron scanvanging Fimbriae - enhance adherance present in all types |
|
Clinical syndromes of Haemophilus influenzae
5 |
Arthritus
epliglotitus meningitis otitis media sinusitis |
|
Haemophilus influenzae sinusitis is caused by what type of Haemophilus influenzae
|
non-encapsulated strain
|
|
most common cause of otitis media in children
|
Haemophilus influenzae
|
|
std common in men, tender papule with erthematous base on the genital or perianal area think
|
H. ducreyi, Chancroid
|
|
Legionella pneumophila morphology
|
gram neg, aerobic, intracellular
|
|
Legionella pneumophila grows on this media
|
charcoal yeast enriched media
|
|
Legionella pneumophila most cases are in
|
summer/fall
|
|
Legionella pneumophila pathogenesis
|
engulfed by macrophages
multiplies macrophage is killed bacteria release |
|
Legionella pneumophila clinical manifestation
|
pulmonary infiltrates multi-lobar
DIC pleuritus, empyema, cavitary lung disease essentially intense inflammatory changes |
|
Legionella pneumophila, extrapulmonary legionellosis occurs in?
|
immunocomprimised hosts via bacteremic spread
|
|
-
|
-
|
|
-
|
-
|
|
-
|
-
|
|
Skin/Soft Tissue /Bone
|
Skin/Soft Tissue /Bone
|
|
When dealing with skin infections always keep what bug in mind
|
Staph A. and MSRA
|
|
Impetigo site, bugs, and clinical features
|
intraepidermal, Group A strep, Staph A, "golden stuck on crusts"
|
|
Folliculitis site, bugs, and clinical features
|
hair follicule, staph a, pustules
|
|
Furuncles site, bugs, and clinical features
|
hair follicule, staph a, deeper nodule that becomes an abscess
|
|
Carbuncle site, bugs, and clinical features
|
hair follicule/subcutaneous fat, staph a, acutley ill, develops from furnuncle, multiple drainage sites for pus
|
|
Ecthyma, site, bugs, and clinical features
|
penetrates epidermis and dermis, group a strep, punched out uclers
|
|
Erysipelas site, bugs, comments
|
Superificial cellulitis with lymphatic involvement, GAS, Lymphatic obstruction is risk factor
Sharp demarcation of bright red lesion |
|
Cellulitis site, bugs, comments
|
Cut and subcut, GAS, MRSA, Spreading infection
portal of entry associated lymphangitis with GAS |
|
Necrotizing fasciitis, site, bugs, comments
|
Subcutaneous soft tissues, fascia, muscle
Type I: polymicrobial (anaerobes, GNB, non-A Strep) Type II: GAS LIFE-THREATENING!! Pain >> physical findings Rapidly progressing Urgent surgical intervention Purplish bullae Fournier’s gangrene: scrotom/perineum |
|
Clostridial myonecrosis site, bugs
|
skeletal muscle, Clostridium perfringens
|
|
“Gas gangrene”
Contaminated wounds LIFE THREATENING Severe pain Skin crepitus Foul odour Gas on plain Xray |
Clostridial myonecrosis from C. Perfringens
|
|
Osteomyelitis – hematogenous
most common bugs in adults 3 |
staph a, strep group a or b
|
|
Osteomyelitis – hematogenous
most common bug in infants |
E-Coli
|
|
Osteomyelitis – hematogenous
most common bug in children |
H.Flu
|
|
Osteomyelitis – hematogenous
most common bug in IVDU |
Pseudo
|
|
most common etiology of osteo in kids
|
Hematogenous spread from trauma
|
|
Osteomyelitis – contiguous focus no vascular insufficiency common bug and usual cause
|
Staph A., direct inoculation after trauma, decubitus ulcers (bedsores)
|
|
Osteomyelitis – contiguous focus with vascular insufficiency bugs and usual cause
|
polymicrobial, minor trauma, common in diabetics
|
|
Septic arthritis common bug infants 3
|
Group B strep, GNB, Staph A.
|
|
Septic arthritis common bug Adolescents
|
N. gonorrhoeae
|
|
Septic arthritis common bug adults
|
Staph a.
|
|
A patient with septic arthritis experiences pain upon what type of joint motion
|
extension
|
|
Septic Bursitis common bug
|
Staph A.
|
|
Septic Bursitis patients experience pain on what type of motion
|
flexion
|