Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
91 Cards in this Set
- Front
- Back
|
Difference b/t Gram+ and Gram-
|
Gram- have both a cytoplasmic and outer membrane
|
|
|
Liptoteichoic acids are...
|
Produced by G+ bacteria and can stimulate adverse inflamm responses
|
|
|
Early dental plaque:
|
Streptococci and Actinomyces
|
|
|
A. naeslundi binds to PRPs absorbe in tooth but not in saliva because:
|
When PRPs adsorb to a surface, a conformational change occurs, revealing a cryptic binding site for Actinomyces
|
|
|
Enamel pellicle
|
Mucins, PRPs, Statherin, Amylase
|
|
|
LPS
|
G-, endotoxins
|
|
|
Infections to cause infection in host
|
gain access to host tissue, multiply within host tissue, resist host defenses, damage host defenses
|
|
|
What protects against phagocytosis of organism?
|
capsules
|
|
|
In what organism does the flagella also function as virulence factor?
|
Vibrio cholera
|
|
|
Neisseria meningitides
|
nasopharyngeal infection
|
|
|
Pseudomonas aeruginosa
|
cycstic fibrosis
UTI, resp exotoxin A resistant to Antibiotics |
|
|
Yersina pestis
|
bubonic plague
temp 37C and low Ca |
|
|
B. pertusis
|
whooping cough
PT adenylate cyclase hemaggulatinin Pertacin NOT enterotoxin |
|
|
H. influenae
|
meningitis
obligate human parasite neeed blood G- |
|
|
Legionella pneumonia
|
bacterial pneumonia - fatal cases in 1970s
|
|
|
Most potent G- coccobacillus
|
Francisella tulareris
|
|
|
Spirochetes
|
G-
motile by endoflagella at least 2 kinds of motility pathogenic CANNOT be cultured on artificial media |
|
|
Pathogenic Spirochetes
|
Leptospira
Borrelia Treponema |
|
|
Oral Spirochetes
|
Treponema
|
|
|
Gummata
|
Tertiary syphilis
|
|
|
Lesions teaming with spirochetes
|
primary shyphilis
|
|
|
Bacillus anthracis
|
complex toxin (LF, EF, PA)
|
|
|
Streptokinase
|
lysis of fibrin clots
|
|
|
Spreading factor in necrotizing fascitis
|
hyaluronidase
|
|
|
Scarlet fever rash
|
hypersensitivity rxn to erythrogenic toxin
|
|
|
rheumetic fever
|
ASO titer
recurrent clonal disease |
|
|
Staph
|
drainage of infected site will NOT produce septicemia
can be isolated from exudates Staph is different from Strep due to coagulase |
|
|
Group A Strep
|
Glomerulonephritis
Rheumetic Fever Erythema nodosum |
|
|
Mycoplasma
|
are true bacteria, but lack a cell wall
difficult to grow in lab smallest free-living microorganism human normal flora |
|
|
Mycoplasma diseases
|
resp, genital, urinary
|
|
|
Mycoplasma hominis
|
Bacterial vaginosis
|
|
|
Actinomyces
|
G+ filamentous
|
|
|
Strep mutans in oral cavity
|
supra-gingival plaque
|
|
|
Primary species in supra-gingival biofilm
|
Actinomyces viscosus
|
|
|
Yeasts, as opposed to molds
|
single cells
reproduce by budding |
|
|
Most common yeast in oral cavity
|
Candida albicans
|
|
|
most common form of oral candidiasis
|
acute pseudomembranous
|
|
|
Chronic atrophic (erythromatous) candidiasis
|
antibiotics, xerostomia, immuno, poor hygiene
|
|
|
Chronic hyperplastic candidiasis (leukoplakia)
|
laterodorsal surface of tongue, anterior buccal mucosa
|
|
|
Cryptococcus neoformans
|
CNS
|
|
|
S. mutans
|
smooth-surface caries lesions
adhere to tooth surface intra and extracellular polysaccharids make lactic acid from sugar |
|
|
Therapeutic endpoint
|
bacteriologic testing
|
|
|
Flouride varnishes
|
have NOT been approved by FDA as caries preventive
|
|
|
PTD, Flouride, min dose
|
5 mg F/kg
|
|
|
Xylitol
|
penitol type of sugar alcohol
|
|
|
what elements dissociate during demineralization
|
calcium and phosphate
|
|
|
S. mutans
|
P1, SpaP or AgI/II
H-ATPase (F1F0-ATPase) |
|
|
OraGen
|
lack of lactate dehydrogenase
productionof a mutacin |
|
|
oral cavity sources for alkali - amonia
|
urea, arginine
|
|
|
S. mutans virulence factors
|
glucosyltransferase
P1 adhesion |
|
|
NOT a risk factor for caries in elderly
|
levels of S. mutans
|
|
|
Pregnancy gingivitis
|
P. intermedia, P. nigrescens
|
|
|
Aa
|
G-, non-spore, nonmotil, facultative anaerobic rod
apical front of subgingival plaque in LAP first pathogen microtubles |
|
|
Campylobacter rectus
|
85% N2, 10%CO2, 5% O2
|
|
|
Campylobacter gracilius
|
anaerobic
rods nonmotile |
|
|
Eikenella corrodens
|
transmitted by bite
|
|
|
P. gingivalis
|
invasion in 20 min
perinuclear area enteric type invasion |
|
|
A.a.
|
actin
replicates within cells binds to integrins and transferrin receptors phospholipase expression |
|
|
P. gingivalis proteases
|
surface and extracellular blebs
peptides for carbon and energy collagenases, peptidases, hyaluronidases NOT related to hagB/C family |
|
|
P. gingivalis
|
wihtin vacuoles within endothelial cells
|
|
|
Eikenella corrodens
|
NOT a risk factor for periodontitis
|
|
|
Generalizzedd gingivities
|
>30% of dentition
|
|
|
Aggressive juvenile periodontitis
|
incisors, first molars, premolars
|
|
|
aggressive juvenile periodontitis
|
rapidly progresses
familial link mild immunological defect A.a. NOT hyper aggressive neutrophils and macrophages |
|
|
RPP
|
genetics
|
|
|
generalized pre-puberty periodontitis
|
NOT assoc with A.a.
|
|
|
antibiotics in dentistry
|
B-lactam antibiotics
Tetracyclies Quinolines Macrolides NOT Polymyxins |
|
|
Augmentin
|
amox and B-lactamase blocker, clavulanic acid
|
|
|
TXT for A.a. periodontitis
|
metronidazole and amox
|
|
|
photosensitivity
|
tetracyclines
ciprofloxacin |
|
|
Metronidazoel
|
against anaerobic bacteria
|
|
|
Helical viruses
|
all have RNA genomes
|
|
|
Infectious virions are produced during
|
lytic infection
|
|
|
Translation of viral proteins following
|
positive polarity RNA viruses
|
|
|
Parvovirus B19
|
5th disease
fatal anemia |
|
|
Poxviridae
|
only DNA virus that can replicate in cytoplasm
|
|
|
Malignant disease
|
EBV
papilomavirus HHV8 |
|
|
Vaccines available for
|
Varicella zoster
Influenza A Hep A |
|
|
Amandatien
|
Influenza A
|
|
|
ToRCH titers
|
rubella
CMV Herpes simplex |
|
|
Poliovirus
|
nucelic acid alone can be infectious
liva and killedvaccines |
|
|
Rhinovirus
|
ability to grow well at 33 celisu
|
|
|
SARS
|
Coronavirus
|
|
|
Rubella
|
only virus in Togaviridae that is not arthropod born
|
|
|
Paramyxovirus
|
induce syncitia formation
|
|
|
antigenic shift
|
segmented genomes
|
|
|
RNA viruses that replicate in cytoplasm
|
picornavirus
togavirus Flavivirus Paramyx NOT orthomyx |
|
|
Hep A
|
infectious Hepatitis
|
|
|
Hep A and Hep C
|
fecal-oral route
|
|
|
Most infectious form of hepatitis
|
Hep B
|
|
|
Hep A
|
spherical capsid
NO envelope |
