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15 Cards in this Set
- Front
- Back
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products of MHC are what : roles |
mem glycoproteins : t cell recognition of antigens (including tissue rejection) |
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a person lacking MHC would have what |
cancer and infection |
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A, B, C where, encode what : DR, DP, DQ where, encode what |
class 1 alpha chains: class 2, alpha and beta genes |
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HMC 1 is made of : what does beta 2 mico do |
alpha 1 2 3 one transmembrane and beta 2 microglobulin : stability |
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MHC 2 made of what |
alpha 1,2 and beta 1,2 : both in membrane |
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dominance in MHC 1 and 2 |
co-dominant |
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MHC 1 on what cells : MHC 2 on what cells : are HMC 1 and 2 multi allelic : |
most nucleated cells (not RBC) : dendritic, macro, (along with MHC 1) b cells : yes : |
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MHC 1 interact with what, MHC 2 |
CD8(cell mediated), CD4(antibody and cell mediated) |
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How man HMC-1 genes does an individual have |
6 |
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T cell receptors can only bind antigen that is bound to what |
MHC |
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what molecules only can bind to MHC |
proteins |
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In endocytic pathway Why are dendritic cells the best antigen presenters : what about macrophages : B cell |
have B7 costimilator and constitutively express MHC : need y-interferon to make MHC and B7 : already have Ig to take up antigen and reexpress on MHC |
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How do proteasome help the presentation of antigen already in the cytoplasm |
virus and tumor cells protein degraded by proteosome goes through TAP(transporter antigen processing) into ER where it can bind to class 1 MHC (stabilized by calnexin which dissociates when protein binds MHC) which can fuse with mem |
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How specific are MHC |
not very |
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cytosolic pathway is for what MHC, Lymphocyte : Endocytic |
MHC-1, CD8 : MHC-2, CD4 |
