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22 Cards in this Set

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In terms of innate and adaptive immunity describe the process of antigen presentation?
Transition stage between the two.
What is an APC
Antigen presenting cell
Give APC example
Dendritic cells
What are the 3 stages of APC action?
Antigen uptake, processing and presentation
What is the end effect of APC action?
Conversion of large and complex antigenic structure into user friendly form
Name professional APCs
Denstritic cells
B cells
Macrophages
Which of the pro APCs are the most potent?
Dendritic
Where does exogenous antigen derive from?
Outside APC, most foreign
Where does endogenous antigen derive from?
Host cell
Autoantigen
Tumor antigen
Alloantigen
integrated viral antigen
What mediates the initial interaction between APC and antigen?
PRR and PAMPs
What is a PRR?
Pattern recognition receptor (some known as toll like receptors
What is PAMP
Pathogen associated molecular pattern
Think about DAMPS
okay
How does the innate response affect the adaptive response?
dictates its nature!
What types of antigen undergoes endosomal processing?
Exogenous
Processed antigens are passed onto...?
MHC class II
How are type endogenous antigensprocessed?
Through Proteasome, EPR and golgi app.
Where are endog antigens presented?
to MHC class I
What family is important in presentation of lipid antigen?
nonpolymorphic CD1 family
How are non pro APCs induceds?
IFN-gamma signalling
Briefly describe how cytokines function.
cytokines binds to specific cytokine receptor leading to altered function of target cell expressing receptor.
What do chemokines do?
recruit leucocytes from blood to tissue