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22 Cards in this Set
- Front
- Back
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In terms of innate and adaptive immunity describe the process of antigen presentation?
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Transition stage between the two.
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What is an APC
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Antigen presenting cell
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Give APC example
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Dendritic cells
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What are the 3 stages of APC action?
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Antigen uptake, processing and presentation
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What is the end effect of APC action?
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Conversion of large and complex antigenic structure into user friendly form
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Name professional APCs
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Denstritic cells
B cells Macrophages |
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Which of the pro APCs are the most potent?
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Dendritic
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Where does exogenous antigen derive from?
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Outside APC, most foreign
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Where does endogenous antigen derive from?
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Host cell
Autoantigen Tumor antigen Alloantigen integrated viral antigen |
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What mediates the initial interaction between APC and antigen?
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PRR and PAMPs
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What is a PRR?
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Pattern recognition receptor (some known as toll like receptors
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What is PAMP
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Pathogen associated molecular pattern
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Think about DAMPS
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okay
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How does the innate response affect the adaptive response?
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dictates its nature!
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What types of antigen undergoes endosomal processing?
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Exogenous
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Processed antigens are passed onto...?
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MHC class II
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How are type endogenous antigensprocessed?
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Through Proteasome, EPR and golgi app.
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Where are endog antigens presented?
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to MHC class I
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What family is important in presentation of lipid antigen?
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nonpolymorphic CD1 family
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How are non pro APCs induceds?
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IFN-gamma signalling
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Briefly describe how cytokines function.
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cytokines binds to specific cytokine receptor leading to altered function of target cell expressing receptor.
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What do chemokines do?
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recruit leucocytes from blood to tissue
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