Med-Chem Test 2

Front 1

Affinity

Back 1

Measures how strong a drug binds to receptor

Just because strong may not guarantee a good mix

Front 2

Efficacy

Back 2

Measure of Maximum biological effect that a drug can produce as a result of receptor binding

High affinity no efficacy antagonist

Front 3

Potency

Back 3

Amount of drug refers to amount of drug required to achieve a defined biological effect. The smaller the dose the more potent the drug

Front 4

P450

Back 4

Phase 1 Transformations catalyzed by chromosome ______

Front 5

Methanol

Back 5

When______ is in your liver it turns to formaldehyde and other awful toxin

Front 6

Gram positive

Back 6

Thick carbohydrate cell wall

Front 7

Gram-negative

Back 7

Thin cell wall additional outer membrane

Front 8

Pharmodynamic

Back 8

The study of how living interact with their target binding site and produce a pharmacological effect the target mechanism

Front 9

Pharmacokinetic

Back 9

Distribute metabolism the whole journey

drug absorption drug distribution drug metabolism drug excretion

Front 10

Prodrug

Back 10

A molecule that is inactive in itself but which is converted to the active drug in the body normally buy an enzymatic reaction

Used to avoid problems related to pharmacokinetics of the active drug and for targeting

Front 11

Bacteriostatic

Back 11

Bacteriostatic drugs inhibit the growth and multiplication of bacteria but do not directly kill them

Front 12

Structure-activity relationships

Back 12

SAR

Studies carried out to determine those atoms or functional groups which are important to drug activity

Front 13

Pharmacophore

Back 13

The atoms and functional groups required for a specific pharmacological activity and their relative positions in space

Front 14

Beta lactams

Back 14

Enzymes that bacteria uses to defend themselves from penicillin it deactivated by opening a beta-lactam ring

Front 15

Hydrophobic sidechain

Back 15

High act vs. Gram-positive and has a poor act vs. Gram-negative

Front 16

Transpeptidase

Back 16

Important bacterial enzyme that catalyzes the final crosslinking of the bacterial cell wall. Targeted by penicillin and cephalosporin. Irreversible hibited by catalyzed horsporans

Front 17

Cephalosporins

Back 17

Disguise structure from penicillin

Front 18

Second generation cephalosporin - cephamycins

Back 18

One has greater residents to beta-lactamase enzyme. Two not active against pseudomonas aeruginosa

Front 19

...

Back 19

Inhibits - Blocks transglycosdiation vancomycin

Front 20

Chloroquine

Back 20

Shows some activity against Gram-negative it was found accidentally

Front 21

Pharmacophore of quinone and fluoroquinolones

Back 21

Pyridine ring and carboxylic acid are a must for activity

Front 22

Protein kinase inhibitors

Back 22

Serine threonine tyrosine are the main three. Cofactor ATP. Focus on binding site to block ATP

Front 23

Has no off switch

Back 23

Aspartate and glutamate

Front 24

Active vs. Inactive

Back 24

GTP vs. GDP

Front 25

Epidermal growth factor

Back 25

EGF

Receptor is a tyrosine kinase inhibitor receptor

Front 26

Ic50

Back 26

Inhibitory concentration you want it to be a small as possible nanometers is better than micrometers

Front 27

Isotere

Back 27

Replacing a group with same valency structure and stericy

Front 28

Bioisotere

Back 28

May not have same valency but the body treats it the same

Front 29

In vitro

Back 29

Pharmacodynamic

Front 30

In viro

Back 30

Pharmacokinetic

Front 31

Ber-abl

Back 31

Diffusion of chromosome 9 + 22

Front 32

Conformational blocker

Back 32

Methane group keeps group from freely rotating helps to maintain structure

Front 33

Type 2 protein kinase inhibitor lilac

Back 33

Prevent from becoming the active form

Front 34

Hydrogen

Back 34

In the ways of size fluorine compares to What atom

Front 35

Ras protein

Back 35

Active _____ normally Auto catalyzes hydrolysis of GTP back to GDP. Key event attaching to hydrophobic chain

Front 36

Metabolic blocker

Back 36

To help prevent oxidation of fluorine can replace a hydrogen

Front 37

Ki

Back 37

Inhibition equilibrium

If _____ is small then it favors the left side

Front 38

Rigidity

Back 38

Things that don't bend but they can eventually break

Zinc is a metal low enzyme co-factor

Front 39

Antagonist

Back 39

Block natural messenger strong more binding interaction

Front 40

Agonist

Back 40

Drug designed to mimic the natural messenger

Front 41

Reverse antagonist

Back 41

When binds does not induce transduction signal or change shape

Front 42

ADME

Back 42

Absorption distribution metabolism excretion

Front 43

A levoli

Back 43

Airsoft with single cell wall surrounded by Blood capillaries around fast effective Exchange

Front 44

:-

Back 44

Vh

Front 45

Polar, fatty

Back 45

Orally taken drugs must be _______ to dissolve in the GI tract and blood supply but also extremely ______ to pass through the cell membranes