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27 Cards in this Set
- Front
- Back
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2 Methods of biotransformation of an estrogen
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Glucuronidation
Sulfation |
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Is the DOA of an unaltered estrogen short or long?
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Short...which is why you substitute at 3 and 17
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Estrace
Generic=? |
Estradiol
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Indications for estrogens...
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--Post menopausal hormone therapy
--Oral contraception --Female primary hypogonadism --Ovarian suppression |
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Most active of the natural esters
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estradiol (estrace)
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Estrone
Brand=? |
theelin
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Theelin
Generic=? |
Estrone
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Premarin
generic=? |
Conjugated estrogens
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conjugated estrogens
brand=? |
Premarin
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where is premarin isolated from
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pregnant mare urine
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what is estrogen conjugated with in premarin
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sodium
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How can premarin be administered?
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IM
IV Oral |
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Contains 9 of 10 known conjugated estrogenic substances
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Cenestin.....a synthetic conjugated estrogen
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contains all 10 known conjugated estrogenic substances
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Enjuvia....a synthetic conjugated estrogen
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What does putting a methyl ether at c3 of an estrogen do to it?
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Makes it a prodrug that has to be hepatically dealkylated for it to work
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17B-HSD=?
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17B-hydroxysteroid dehydrogenase
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What could you put on an estrogen at c17 to block hepatic oxidation by 17b-HSD?
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ethinyl. It will keep it from turning hte 0H into a keto
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What ester salts at c17 of an estrogen does what?
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makes it lipid soluble, must first be hydrolyzed by an esterase to release the estrogen
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Estradiol valerate
Brand=? |
Delestrogen
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Delestrogen
Generic=? |
Estradiol valerate
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Method of administering Estradiol valerate (Delestrogen)?
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IM
Transderm NOT ORAL!!!!!! |
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DOA of Estradiol valerate (delestrogen)
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14-21 days
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Estradiol cypionate
brand=? |
Estra-Cyp
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Estra-Cyp
Generic=? |
Estradiol Cypionate
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DOA of estra-cyp (estradiol valerate)?
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14-28 days
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Delivery method of estradiol cypionate?
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IM
Transdermal |
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what type of estrogens are used in OCPs?
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Semi-synthetic estrogens:
Ethinyl Estradiol 17a-ethinyl Estradiol 3-Methyl Ether |
