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9 Cards in this Set
- Front
- Back
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efficacy is measured as what : potency |
the Emax : the E50 |
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If a drug is a partial agonist what does that tell you about the binding affinity compared to the full agonist |
nothing! |
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what does a quantal dose tell you, good for what |
only the frequency of the outcome not how much, especially good for lethal doses |
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does an antagonist have efficacy |
never |
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what else can a partial agonist do |
block effect of full agonist or endogenous substance |
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how an the ED50 be moved to the right, what happens to Emax : what will a non-competitive antagonist do |
by adding a competitive antagonist, doesn't change : lower Emax not E50 |
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what is dispositional tolerance |
reduction in drug effect with change in concentration usually do to activating the system that breaks it down |
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what is pharmacodynamic tolerance |
reduction in drug effect without a change in concentration, such as receptor down regulation |
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what is behavioral tolerance |
CNS drugs make learned responses that allow the individual to overcome the effects |
