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efficacy is measured as what : potency
the Emax : the E50
If a drug is a partial agonist what does that tell you about the binding affinity compared to the full agonist
nothing!
what does a quantal dose tell you, good for what
only the frequency of the outcome not how much, especially good for lethal doses
does an antagonist have efficacy
never
what else can a partial agonist do
block effect of full agonist or endogenous substance
how an the ED50 be moved to the right, what happens to Emax : what will a non-competitive antagonist do
by adding a competitive antagonist, doesn't change : lower Emax not E50
what is dispositional tolerance
reduction in drug effect with change in concentration usually do to activating the system that breaks it down
what is pharmacodynamic tolerance
reduction in drug effect without a change in concentration, such as receptor down regulation
what is behavioral tolerance
CNS drugs make learned responses that allow the individual to overcome the effects
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