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7 Cards in this Set
- Front
- Back
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Warfarin |
Warfarin - competitively inhibits vit K epoxide reductase that converts the vit K dependent coagulation factors to their active form |
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Aspirin |
Aspirin - irreversibly acetylates cyclooxygenase and thereby prevents formation of thromboxane A2 |
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P2Y12 inh |
P2Y12 inh Clopidogrel/ prasugel- irreversible Ticagrelor - reversible binding Irreversibly binds to P2Y12 rec thereby blocking ADP binding. This P2Y12 rec antagonism inhibits ADP- mediated platelet activation and aggregation |
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Heparin |
Heparin- binds to antithrombin enhancing the rate of thrombin - AT compels formation by up to 10 000 times UFH binds and (-) ATIII (not AT) |
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Glycoprotein IIb/ IIIa inh |
Glycoprotein IIb/ IIIa Eg Tirofiban - reversible inhibition of PLT GP IIb/ IIIa rec - blocks final pathway of platelet aggregation - it does not block platelet adhesion/ release reaction |
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Platelet phosphodiesterase inh |
Platelet phospho/ diesterase inh Dipyrimadole Inhibition of uptake of adenosine into platelets -> decrease adhesion to damaged vessel walls
Dipyrdamole has 3 actions- don’t forget that it (-) PDE in plt-> inc cAMP -> dec Ca -> dec Phospholipase A2 from Arach Acid -> dec TXA2 (also potentiates PGI2 hence potent vasodilator) |
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Tranexamic Acid |
Tranexamic Acid - lysine derivative that inhibits the conversion of plasminogen to plasmin |
