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Warfarin
Warfarin - competitively inhibits vit K epoxide reductase that converts the vit K dependent coagulation factors to their active form
Aspirin
Aspirin - irreversibly acetylates cyclooxygenase and thereby prevents formation of thromboxane A2
P2Y12 inh
Clopidogrel/ prasugel- irreversible
Ticagrelor - reversible binding
Irreversibly binds to P2Y12 rec thereby blocking ADP binding. This P2Y12 rec antagonism inhibits ADP- mediated platelet activation and aggregation
Heparin
Heparin- binds to antithrombin enhancing the rate of thrombin - AT compels formation by up to 10 000 times
UFH binds and (-) ATIII (not AT)
Glycoprotein IIb/ IIIa inh
Glycoprotein IIb/ IIIa
Eg Tirofiban - reversible inhibition of PLT GP IIb/ IIIa rec
- blocks final pathway of platelet aggregation
- it does not block platelet adhesion/ release reaction
Platelet phosphodiesterase inh
Platelet phospho/ diesterase inh
Dipyrimadole
Inhibition of uptake of adenosine into platelets -> decrease adhesion to damaged vessel walls
Dipyrdamole has 3 actions- don’t forget that it (-) PDE in plt-> inc cAMP -> dec Ca -> dec Phospholipase A2 from Arach Acid -> dec TXA2 (also potentiates PGI2 hence potent vasodilator)
Tranexamic Acid
Tranexamic Acid - lysine derivative that inhibits the conversion of plasminogen to plasmin
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