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15 Cards in this Set

  • Front
  • Back
List the MACROLIDE antibiotics ?
ERYTHROMYCIN (prototype for the class)
Azithromycin (Zithromax)
Dirithromycin (Dynabac)
Clarithromycin (biaxin)
How do the macrolides work ?
They are BACTERIOSTATIC (at normal doses) and inhibit protein synthesis
-can be bacteriocidal against susceptible organisms
The antimicrobial spectrum of the macrolides is similar to what other group of antibiotics ?
-gram positive and some gram negative action
Macrolides/Erythromycin are the treatment of choice against ????
Pnuemonia caused by Legionalla (Legionairres)
-Pertussis (whooping cough)
-diptheria (Corynebacterium diptheriae)
Erythromycin is a good alternative to what drug ?
Penicillin...for those who are pen allergic
-to treat respiratory infections caused by strep pneumonia or strep pyrogenes
A prophylactic use of this drug would involve giving it to prevent ? before going to the ?
to prevent bacterial endocarditis before going to the dentist
Should you take erythromycin with or without food ? Why ?
without; food decreases the absorption of erythromycin
Erythryomycin INHIBITS the hepatic drug metabolizing enzyme P450...what does this mean ?
Will elevate drug levels of terfanadine and astemizole (arrhythmias);
PBGCTR (coumadin, theophylline, carbamazepine)..drug levels will be increased
Patients should take erythromycin on...
an empty stomach with a full glass of water
Erythromycin should not be given at the same time with what two antibiotics ?
Cloramphenicol and Cleocin
Which macrolide does NOT inhibit CP450 ?
Azithromycin (Zithromax)
What are the signs and symptoms of liver injury that you should warn patients about ?
Pale stools, yellow skin, darkened urine, abdominal pain
Macrolides are readily distributed to the CNS. True or False ?
Always remember to stop these drugs when putting a patient on macrolides...
Which of the macrolides can be prescribed safely during pregnancy ?
Zithromax (Azithromycin)