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15 Cards in this Set
- Front
- Back
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List the MACROLIDE antibiotics ?
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ERYTHROMYCIN (prototype for the class)
Azithromycin (Zithromax) Dirithromycin (Dynabac) Ketek Clarithromycin (biaxin) |
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How do the macrolides work ?
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They are BACTERIOSTATIC (at normal doses) and inhibit protein synthesis
-can be bacteriocidal against susceptible organisms |
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The antimicrobial spectrum of the macrolides is similar to what other group of antibiotics ?
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PENICILLINS
-gram positive and some gram negative action |
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Macrolides/Erythromycin are the treatment of choice against ????
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Pnuemonia caused by Legionalla (Legionairres)
-Pertussis (whooping cough) -diptheria (Corynebacterium diptheriae) |
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Erythromycin is a good alternative to what drug ?
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Penicillin...for those who are pen allergic
-to treat respiratory infections caused by strep pneumonia or strep pyrogenes |
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A prophylactic use of this drug would involve giving it to prevent ? before going to the ?
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to prevent bacterial endocarditis before going to the dentist
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Should you take erythromycin with or without food ? Why ?
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without; food decreases the absorption of erythromycin
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Erythryomycin INHIBITS the hepatic drug metabolizing enzyme P450...what does this mean ?
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Will elevate drug levels of terfanadine and astemizole (arrhythmias);
PBGCTR (coumadin, theophylline, carbamazepine)..drug levels will be increased |
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Patients should take erythromycin on...
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an empty stomach with a full glass of water
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Erythromycin should not be given at the same time with what two antibiotics ?
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Cloramphenicol and Cleocin
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Which macrolide does NOT inhibit CP450 ?
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Azithromycin (Zithromax)
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What are the signs and symptoms of liver injury that you should warn patients about ?
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Pale stools, yellow skin, darkened urine, abdominal pain
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Macrolides are readily distributed to the CNS. True or False ?
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FALSE
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Always remember to stop these drugs when putting a patient on macrolides...
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STATINS
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Which of the macrolides can be prescribed safely during pregnancy ?
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Zithromax (Azithromycin)
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