Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
9 Cards in this Set
- Front
- Back
|
Hypothalamus / Pituitary axis |
Growth hormone secreted in pituitary gland by somatotrophs and circulates through body |
|
|
Hypertrophy |
Large growth plates at end of bones when growing Caused by growth hormoone |
|
|
Somatomedin hypothesis |
GH regulates IGF-1 IGF-1 produced in life under influence GH IGF-1 from liver allows proliferation bones
Not true - GH and IGF act independently - liver IGF not much effect upon growth |
|
|
Thyroxine |
Pygmies Iodine deficiency |
|
|
Estrogen |
Growth repressor Seals growth plates Absence of testicular estrogen results in euchunoid phenotype |
|
|
Daf-2 |
Mutation makes it daf constitutive i.e. dauer formation when conditions favourable Cell autonomous - acts in all tissues as recepotr for insulin like protein |
|
|
Daf-2 represses |
Forkhead TF Daf-16 Daf-16 critical in downstream longevity If daf2 (-/-) daf-16 upregulated, increased longevity |
|
|
Daf-2 represses |
Stress response genes e.g. SOD3 Catalase genes Heat shock proteins Ageing free radical theory wear and tear |
|
|
Daf-2 activates |
Vitellogenenins e.g. vit-2 vit-5 Ageing - cost of reproduction theory |
