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24 Cards in this Set
- Front
- Back
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Most common cancer in kids (especially age 2-5) |
ALL |
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Far more common in kids with Down Syndrome |
ALL ("we ALL fall DOWN") |
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Presents primarily with bone pain as well as fever, LAD, fatigue and recurrent infxns |
ALL |
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Labs shows large cells w/ pale blue cytoplasm prominent nuclei and are + for PAS and TdT Anemia Thrombocytopenia Normal to slightly high WBC |
ALL |
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Occurs mainly in midlife adults and presents with fatigue, easy bruising, recurrent infxns |
AML |
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Labs show large cells that stain + for myeloperoxidase and may show Auer Rods |
AML *Subtype M3 has auer rods |
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Occurs in midlife adults presenting with fatigue, spleenomegaly, bleeding. Chromosomal analysis shows Philidelphia chromosome t (9, 22) |
CML |
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What is a potentially lethal complication of CML? |
Blast Crisis - sudden conversion to AML that is very resistant to treatment. Requires urgent BM transplant |
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Labs show Anemia, thrombocytosis, ↑↑↑ WBC |
CML |
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What chemotherapeutic is especially targeted towards CML with tremendous success? |
Tyrosine Kinase Inhibitors - Imatinib, Dasatinib, Nilotinib (end in "-nib") |
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Presents mainly in elderly (over 65) and is usually asymptomatic but can display "B-Symp" Labs show severe leukocytosis and "smudge" cells How can this be managed? |
CLL - can be managed with periodic monitoring! |
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"Pre-Leukemia" like condition seen in elderly (over 65) that is often asymptomatic but may show symptoms of low cell counts |
Myelodysplastic Syndrome |
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Labs show Macrocytic anemia, hypogranular neutropenia, low plts and the finding to the left |
Myelodysplastic Syndrome *pictured neutrophil has Pseudo Pelger-Huet Anomaly |
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Most common leukemia in adults? |
CLL |
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What is this finding and what disease is found in? What chemo agent is best for this disease? |
Multiple Myeloma - "Clock-Face" clumped chromatin with perinuclear "hough" - Trx w/ Lenalidomide + BM transplant |
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What is the presenting age group of the disease associated with this finding? What classic symptoms can you expect? |
Hodgkin Lymphoma - Reed-Sternberg cell shown - Bimodal age distribution = 20 and 65 - B-symp + Painless CERVICAL LAD (compared to painless GENERALIZED LAD found in Non-hodgekins) |
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Which Hodgkin Lymphoma is the most common? Has the best prognosis? Worst prognosis? |
MC = Nodular Sclerosis Best Prog = Lympho-rich Worst Prog = Lympho-depleted |
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What is the most common Non-Hodgkin Lymphoma that is seen mainly in old men? |
Diffuse large B-cell |
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What is the most common Non-Hodgkin Lymphoma in kids? |
Lymphoblastic Lymphoma |
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Which Non-Hodgkin Lymphoma has this finding? What translocation is it associated with? |
Follicular Lymphoma - t (14, 18) |
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Which Non-Hodgkin Lymphoma has this finding? What translocation is it associated with? Diseases? |
Burkitt's Lymphoma - t (8, 14) - EBV and HIV |
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Which Non-Hodgkin Lymphoma has malignant cell identical to CLL but is in a solid form? |
Small Lymphocytic Lymphoma |
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Which Non-Hodgkin Lymphoma has this finding? |
Hairy cell leukemia |
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What d/o causes thrombosis, Erythomelalgia (burning pain in hands and feet with change in color), puritis, and facial plethora? What is the treatment? |
Polycythemia Vera - Trx = Hydroxyurea + ASA |
