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65 Cards in this Set
- Front
- Back
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comes from T lymphoblasts
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T-ALL
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child with a thymic mass
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T-ALL
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TdT+
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T-ALL
B-ALL |
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comes from CD4+ T cells
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adult T cell leukemia/lymphoma or mycosis fungoidies
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HTLV-1 causes
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adult T cell leukemia and lymphoma
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causes pautrier microabscesses and sezary syndrome
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mycosis funigicoides
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BALL t(12;21)
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good prognosis; children, down's syndrome
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BALL t(9;22)
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poor prognosis, adults
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comes from naive b cells
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lymphomas
chronic lymphocytic leukemia |
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CD5 and CD20 present, smudge cells seen on smear
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chronic lymphocytic leukemia
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chronic lymphocytic leukemia transforms to
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diffuse large B cell lymphoma
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TRAP
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hairy cell leukemia
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dry tap on BM bx, no lymphadenopathy, splenomegaly present
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hairy cell leukemia
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from megakaryaoblasts
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AML- acute megakaryoblastic leukemia
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lacks MPO, in adults
in Down's syndrome < 5 |
AML- acute megakaryoblastic leukemia
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from megakaryocytes
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myelofibrosis
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neoplastic proliferation of megakaryocytes causing bleeding, thrombosis, infection
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myelofibrosis
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teardrop RBCs seen
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myelofibrosis
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comes from platelets
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essential thrombocythemia
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JAK2 kinase mutation with bleeding and clotting
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essential thrombocythemia
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chronic lymphocytic leukemia transforms to
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diffuse large B cell lymphoma
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TRAP
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hairy cell leukemia
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dry tap on BM bx, no lymphadenopathy, splenomegaly present
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hairy cell leukemia
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from megakaryaoblasts
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AML- acute megakaryoblastic leukemia
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lacks MPO, in adults
in Down's syndrome < 5 |
AML- acute megakaryoblastic leukemia
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from megakaryocytes
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myelofibrosis
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neoplastic proliferation of megakaryocytes causing bleeding, thrombosis, infection
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myelofibrosis
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teardrop RBCs seen
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myelofibrosis
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comes from platelets
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essential thrombocythemia
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JAK2 kinase mutation with bleeding and clotting
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essential thrombocythemia
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comes form monoblasts
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AML-acute monocytic leukemia
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lacks MPO, in adults, infiltrates gums
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AML-acute monocytic leukemia M5
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come from myeloblasts
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AML- acute myeloblastic and promyleocytic leukemias
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t(8;21)
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acute myeloblastic leukemia
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t(15;17)
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M3 AML- acute promyelocytic
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auer rods, DIC, retinoic acid receptor disruption
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M3 AML- acute promyelocytic
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comes form neutrophils, basophils, eosinophils
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chronic myeloid leukemia
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t(9;22)
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bcr-abl in CML
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high neutrophil precursors: leukemoid rxn vs. CML
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high alk phos- leukemoid reaction
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comes form RBC's
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polycythemia vera
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JAK2 kinase mutation, low EPO
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polycythemia vera
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high RBC with high altitude
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reactive polycythemia
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enlarging cervical or mediastinal lymph nodes in young adult female; bipsy shows LN divided by binds of sclerotic tissue
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nodular sclerosing hodgkins
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most common hodgkins
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nodular sclerosing
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most aggressive hodgkins
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lymphocyte depleted
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hodgkins seen in elderly and HIV+
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lymphocyte depleted
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RS cells make IL-5, abundant eosinophils present
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mixed cellularity Hodgkins
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best prognosis hodgkins
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lymphocyte rich
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reed sternberg cells cause
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B symptoms, attract reactive lymphocytes, plasma cells, M0, eosinophils, may cause fiborsis
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most common lymphoma in the US
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diffuse large B cell
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presents in late adulthood with enlarging lymph node and mass
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diffuse large B cell
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t(8; 14)
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burkitts, c-myc
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starry sky
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burkitts
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t(14; 18)
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follicular bcl-2
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bcl-2
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inhibits apoptosis
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painless lymphadenopathy, adults, disruption of normal lymph node, monoclonality, only treat if symptomatic
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follicular
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t(11;14)
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mantl zone, increased cyclin D1
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caused by H pylori, hashimotos, sjogren
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marginal
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postgermial center B cell lymphoma
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marginal cell
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most common primarymalignancy of bone
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multiple myeloma
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generalized lymphadenopathy, M spike-> Igm, hypervisocosity, retinal hemorrhage, stroke
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waldenstrom's
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birbeck granules
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langerhans cell histiocytosis
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malignant langerhans cell histiocytosis; skin rash and cystic skeletal defects in an infant; multiorgan involvement, rapidly fatal
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letter-siwe
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benign langerhans cell histiocytosis; pathologic fracture in adult/adolescent, biopsy shows mixed cellularity with inflammatory cells on bx, eosinophils present
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eosinophilic granuloma
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malignant langerhans cell histiocytosis; scalp rash, lytic skull defects, DI, exopthalmos in a child
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hand-schuller-christian
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