Lecom One Liners- Pharm- Opioids/drugs Of Abuse

Front 1

Inhibit synaptic activity of primary afferents and spinal cord pain transmission neurons

Back 1

Ascending pathways

Front 2

Activation of these receptors close Ca2+ ion channels to inhibit neurotransmitter release *

Back 2

Presynaptic mu, delta, and kappa receptors

Front 3

Activation of these receptors open K+ ion channels to cause membrane hyperpolarization

Back 3

Postsynaptic Mu receptors

Front 4

Tolerance to all effects of opioid agonists can develop except*

Back 4

Miosis and constipation

Front 5

All opioids except this agent (which has a muscarinic blocking action) cause pupillary constriction

Back 5

Meperidine

Front 6

SE of these drugs include dependence, withdrawal syndrome, sedation, euphoria, respiratory depression nausea and vomiting, constipation, biliary spasm, increased ureteral and bladder tone, and reduction in uterine tone

Back 6

Opioid Analgesics

Front 7

Strong opioid agonists

Back 7

Morphine, methadone, meperidine, and fentanyl

Front 8

Opioids used in anesthesia

Back 8

Morphine and fentanyl

Front 9

Opioid used in the management of withdrawal states*

Back 9

Methadone

Front 10

Opioid available trans-dermally *

Back 10

Fentanyl

Front 11

Opioid that can be given PO, by epidural, and IV, which helps to relieve the dyspnea of pulmonary edema*

Back 11

Morphine

Front 12

Use of this opioid with MAOI can lead to hyperpyrexic coma, and with SSRI's can lead to serotonin syndrome

Back 12

Meperidine

Front 13

Moderate opioid agonists*

Back 13

Codeine, hydrocodone, and oxycodone

Front 14

Weak opioid agonist, poor analgesic, its overdose can cause severe toxicity including respiratory depression, circulatory collapse, pulmonary edema, and seizures

Back 14

Propoxyphene

Front 15

Partial opioid agonist, considered a strong analgesic, has a long duration of action and is resistant to naloxone reversal

Back 15

Buprenorphine

Front 16

Opioid antagonist that is given IV and had short DOA*

Back 16

Naloxone

Front 17

Opioid antagonist that is given orally in alcohol dependency programs *

Back 17

Naltrexone

Front 18

These agents are used as antitussive

Back 18

Dextromethorphan, Codeine

Front 19

These agents are used as antidiarrheal

Back 19

Diphenoxylate, Loperamide

Front 20

Inhalant anesthetics

Back 20

NO, chloroform, and diethyl ether

Front 21

Toxic to the liver, kidney, lungs, bone marrow, peripheral nerves, and cause brain damage in animals, sudden death has occurred following inhalation

Back 21

Fluorocarbons and Industrial solvents

Front 22

Cause dizziness, tachycardia, hypotension, and flushing

Back 22

Organic nitrites

Front 23

Causes acne, premature closure of epiphyses, masculinization in females, hepatic dysfunction, MI, and increases in libido and aggression

Back 23

Steroids

Front 24

Readily detected markers that may assist in diagnosis of the cause of a drug overdose include*

Back 24

Changes in heart rate, blood pressure, respiration, body temperature, sweating, bowel signs, and pupillary responses

Front 25

Most commonly abused in health care professionals

Back 25

Heroin, morphine, oxycodone, meperidine and fentanyl

Front 26

This route is associated with rapid tolerance and psychologic dependence

Back 26

IV administration

Front 27

Leads to respiratory depression progressing to comaand death*

Back 27

Overdose of opioids

Front 28

Lacrimation, rhinorrhea, yawning, sweating, weakness, gooseflesh, nausea, and vomiting, tremor, muscle jerks, and hyperpnea are signs of this syndrome

Back 28

Abstinence syndrome

Front 29

Treatment for opioid addiction

Back 29

Methadone, followed by slow dose reduction

Front 30

This agent may cause more severe, rapid and intense symptoms to a recovering addict*

Back 30

Naloxone

Front 31

Sedative-Hypnotics action

Back 31

Reduce inhibition, suppress anxiety, and produce relaxation

Front 32

Additive effects when Sedative-Hypnotics used in combination with these agents

Back 32

CNS depressants

Front 33

Common mechanism by which overdose result in death

Back 33

Depression of medullary and cardiovascular centers

Front 34

"Date rape drug" *

Back 34

Flunitrazepam (rohypnol)

Front 35

The most important sign of withdrawal syndrome

Back 35

Excessive CNS stimulation (seizures)

Front 36

Treatment of withdrawal syndrome involves

Back 36

Long-acting sedative-hypnotic or a gradual reduction of dose, clonidine or propranolol

Front 37

These agents are CNS depressants *

Back 37

Ethanol, Barbiturates, and Benzodiazepines

Front 38

Withdrawal from this drug causes lethargy, irritability, and headache

Back 38

Caffeine

Front 39

W/D from this drug causes anxiety and mental discomfort

Back 39

Nicotine

Front 40

Treatments available for nicotine addiction*

Back 40

Patches, gum, nasal spray, psychotherapy, and bupropion

Front 41

Chronic high dose abuse of nicotine leads to

Back 41

Psychotic state, overdose causes agitation, restlessness, tachycardia, hyperthermia, hyperreflexia, and seizures

Front 42

Tolerance is marked and abstinence syndrome occurs

Back 42

Amphetamines

Front 43

Amphetamine agents

Back 43

Dextroamphetamines and methamphetamine

Front 44

These agents are congeners of Amphetamine

Back 44

DOM, STP, MDA, and MDMA "ecstasy"

Front 45

Overdoses of this agent with powerful vasoconstrictive action may result in fatalities from arrhythmias, seizures, respiratory depression, or severe HTN (MI and stroke)

Back 45

Cocaine "super-speed"

Front 46

Most dangerous of the currently popular hallucinogenic drugs, OD leads to nystagmus, marked hypertension, and seizures, presence of both horizontal and vertical nystagmus is pathognomonic

Back 46

PCP

Front 47

Removal of PCP may be aided

Back 47

Urinary acidification and activated charcoal or continual nasogastric suction

Front 48

THC is active ingredient, SE's include impairment of
judgment, and reflexes, decreases in blood pressure
and psychomotor performance occur
*

Back 48

Marijuana