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221 Cards in this Set

  • Front
  • Back

The brainstem sits between which 2 junctions?

midbrain-diencephalic junction and cervicomedullary junction

The tectum (roof) of the midbrain is formed by ...

superior and inferior colliculi

The interpeduncular fossa sits on which surface of the midbrain (ventral, dorsal, rostral, caudal etc.)

ventral surface of midbrain has the cerebral peduncles

Major anatomical difference between the rostral and caudal medulla

In the rostal medulla, the inferior olivary nuclei can be seen just lateral to te pyramids. In the caudal medulla, the inferior olivary nuclei can no longer be seen, but the posterior columns and posterior column nuclei are visicle on the dorsal surface

What is the obex?

the lower limit of the 4th ventricle; marks entry into the spinal cord central canal (normally closed in adults)

CN 2 transmits light from the retina to the ...

lateral geniculate body of thalamus

CN 4 arises from ...

dorsal midbrain

CN 5 arises from ...

pons

CN 1 enters the skull through which foramen?

cribriform plate of ethmoid bone

CN 2 enters the skull through which foramen?

optic canal

CN V2 exits the skull via which foramen?

foramen rotundum

CN V3 exits the skull via which foramen?

foramen ovale

CN 7 and 8 exit the cranial cavity via which foramen?

internal auditory meatus

CN 7 exits the skull via which foramen?

stylomastoid foramen

CN 9, 10, 11 exit the skull via which foramen?

jugular foramen

CN 12 exits the skull via which foramen?

hypoglossal canal

CN 3, 4, V1, 6 exit the skull via which foramen?

superior orbital fissure

CN 11 cervical branches enter the skull via which foramen?

foramen magnum

3 motor columns of cranial nerves

Branchial (SVE), parasympathetic (GVE) and somatic (GSE) motor columns

3 sensory columns of cranial nerves

Special somatic (SSA), general somatic (GSA), Visceral (SVA) sensory columns

Which cranial nerves are found in the Somatic motor column?

3, 4, 6, 12

Which cranial nerves are found in the Branchial motor column?

5, 7, 9, 10, 11

Which cranial nerves are found in the Parasympathetic motor column?

3, 7, 9, 10

Which cranial nerves are found in the General somatic sensory column?

5, 7, 9, 10 (trigeminal nucleus)

The trigeminal nucleus has which cranial nerve fibers

5, 7, 9, 10 sensory fibers

Which cranial nerves are found in the Visceral sensory column?

7, 9, 10 (taste and visceral afferents)- nucleus solitarus

Which cranial nerves are found in the Special somatic sensory column?

CN 8 for hearing (cochlear and vestibular nuclei)

Nucleus ambiguous contains what cranial nerve fibers?

9, 10 motor fibers

Nucleus solitarus contains what cranial nerve fibers?

7, 9, 10 sensory

Trigeminal Nucleus contains what cranial nerve fibers?

5, 7, 9, 10 sensory

The somatic motor nuclei are derived embryologically from ________

occiptal somites

Brainstem Exit: CN I

Telencephalon

Brainstem Exit: CN II

Diencephalon

Brainstem Exit: CN III

ventrally from interpenduncular fossa

Brainstem Exit: CN IV

dorsal midbrain from the inferior tectum

Brainstem Exit: CN V

ventrolateral pons

Brainstem Exit: CN VI

ventrally at pontomedullary junction

Brainstem Exit: CN VII

cerebellopontine angle

Brainstem Exit: CN VIII

cerebellopontine angle

Brainstem Exit: CN IX

cerebellopontine angle

Brainstem Exit: CN X

Medulla (posterior to inferior olive)

Brainstem Exit: CN XI

Medulla; arises laterally from multiple rootlets in the cervical spine

Brainstem Exit: CN XII

Medulla (between pyramids and inferior olivary nuclei)

Function: Ciliary ganglion

parasympathetic to iris and ciliary muscle (CN III)

Function: Trigeminal ganglion (semilunar or gasserian ganglion)

Primary sensory neuron cell bodies for sensation in the face, mouth, sinuses, and supratentorial meninges (CN V)

Function: Sphenopalatine (pterygopalatine) ganglion:

Parasympathetics to lacrimal glands and nasal mucosa (CN VII)

Function: Submandibular ganglion

Parasympathetic to submandibular and sublingual salivary glands (CN VII)

Function: Geniculate ganglion

Primary sensory neuron cell bodies for taste sensation in the anterior 2/3 of tongue, and for sensation near outer ear (CN VII)

Function: Spiral ganglion

Primary sensory neuron cell bodies for hearing (CN VIII)

Function: Scarpa's vestibular ganglion

Primary sensory neuron cell bodies for vestibular sensation (CN VIII)

Function: Otic ganglion

Parasympathetics to parotid gland (CN IX

Function: Superior (jugular) glossopharyngeal ganglion

Primary sesory neuron cell bodies for sensation from middle ear, external auditory meatus, pharynx, and posterior 1/3 tongue (CN IX)

Function: Inferior (petrosal) glossopharyngeal ganglion

Primary sensory neuron cell bodies for sensation from middle ear, external auditory meatus, pharynx, posterior 1/3 of tongue, for taste posterior tongue, and for carotid inputs (CN IX)

Function: Parasympathetic ganglia in end organs

parasympathetics to heart, lungs, digestive tract to level of splenic flexure (CN X)

Function: Superior (jugular) vagal ganglion

Primary sensory neuron cell bodies for sensation from pharynx, outer ear, and infratentorial meninges (CN X)

Function: Inferior (nodose) vagal ganglion

Primary sensory neuron cell bodies for laryngeal sensation, for taste from epiglottis, and for reflex inputs from aortic arch receptors and other thoracoabdominal viscera (CN X)

Function CN I

olfaction

Function CN II

vision

Function CN III

-levator palpebrae superior and all extraocular muscles, excpet for superior oblique and lateral rectus
-Parasympathetics to pupil constrictor and ciliary muscles for near vision

Function CN IV

Superior oblique muscle; causes depression and intorsion of the eye

Function CN V

-Sensations of pain, touch, temperature, joint position, and vibration for the face, mouth, anterior 2/3 tongue, nasal sinuses, and meninges
-Muscles of mastication and tensor tympani muscle

Function CN VI

Lateral rectus muscle; causes abduction of the eye

Function CN VII

-Muscles of facial expression, stapedius muscle, and part of digastric muscle
-Parasympathetics to lacrimal glands, and to sublingual, submandibular, and all other salivary glands except parotid
-Taste anterior 2/3 tongue
-Sensation from a small region near the external auditory meatus

Function CN VIII

Hearing and vestibular sensation

Function CN IX

-Stylopharyngeus muscle
-Parasympathetics to parotid gland
-Sensation from middle ear, region near external auditory meatus, pharynx, and posterior 1/3 tongue
-Taste posterior 1/3 tongue
-Chemo- and baroreceptors of carotid body

Function CN X

-Pharyngeal muscles (swallowing) and laryngeal muscles (voice box)
-Parasympathetics to heart, lungs, and digestive tract down to splenic flexure
-Sensation from pharynx, meninges, and a small region near the external auditory meatus
-Taste from epiglottis and pharynx
-Chemo- and baroreceptors of aortic arch

Function CN XI

Sternomastoid and upper part of trapezius muscle

Function CN XII

Intrinsic muscle tongue

What is anosmia?

inability to smell, CN1 damage

Unilateral vs. bilateral anosmia

Patients are ofte unaware of unilateral because olfaction in the contralateral nostril can compensate; patients are aware of bilateral anosmia and often after a decreased sense of taste

Causes of anosmia

head trauma, viral infections, obstruction of the nasal pathway, neurodegenerative diseases (Parkinson's, Alzheimer's); intracranial lesions that occur at the base of frontal lobes (meningioma, metastases, basal meningitis, sarcoidosis)

Foster Kennedry Syndrome

anosmia together with optic atrophy in one eye (caused by ipsilateral tumor compression) and papilledema in the other eye (caused by elevated intracranial pressure)

A patient presents with a blown pupil. Which cranial nerve tract is most likely blown?

parasympathetic motor tract containing CN3 parasympathetic from Edinger-Westfall nucleus

Location: CN III nuclei

midbrain

Location: CN IV nuclei

midbrain

Location: CN VI nucei

pons

Once CN3, 4, 6 leave their origins, how do they all get to the extra-occular eye muscles?

cavernous sinus, then exit superior orbital fissure

Describe the path of the parasympathetic from CN3 to the eye.

From the Edinger-Westfall nucleus > out interpeduncular fossa> through superior orbital fissure> parasympathetic to the ciliary ganglion where they synapse on postganglionic neurons > pupillary constrictor muscles and ciliary muscle

CN 3 parasympathetic preganglionics are located ...

in the Edinger-Westfall nucleus of the superior colliculi

CN 3 sympathetic preganglionics are located ...

in the IML of T1-T4 spinal cord

CN 3 sympathetic postganglionics are located ...

in the superior cervical ganglion of the paravertebral column

Three divisions of trigeminal

V1: opthalmic
V2: maxillary
V3: mandibular

Pathway trigeminal nerve:

exits the brainstem from the ventrolateral pons --> enters a small fossa just posterior and inferolateral to the cavernous sinus called Meckel's cave (location of trigeminal nucleus) --> division into V1, V2, and V3

Where is the trigeminal ganglion located?

Meckel's cave

The trigeminal nucleus relays sensory information to what part of the thalamus?

VPM

Tensor tympani is innervated by which CN?

V3

Sensory Modalities: Mesencephalic Trigeminal Nucleus

Proprioception

Sensory Modalities: Chief trigeminal sensory nucleus

fine touch; dental pressure

Sensory Modalities: Spinal trigeminal nucleus

crude touch; pain; temperature

Location: Cheif trigeminal sensory nucleus

lateral pons

Location: Spinal trigeminal nucleus

lateral pons and medulla, extending down to the upper cervical spine

The Spinal Trigeminal Tract is analogous to

Lissauer's Tract

The trieminothalamic tract is analogous to

Spinothalamic tract

Somatotropic organization of spinal trigeminal tract

mandibular division dorsally, the opthalmic division ventrally, and the maxillary division in between

Location: mesencephalic nucleus and tract

runs along the lateral edge of the periaqueductal gray matter in the midbrain

What is the only case in which the primary sensory neurons lie within the CNS instead of the peripheral ganglia?

Mesencephalic trigeminal nucleus

A unilateral upper motor lesion of the corticobulbar tract leads to what deficits?

none, upper motor control is bilateral to the trigeminal motor nucleus

What is trigeminal neuralgia?

tic douloureux; severe pain from non-painful stimuli

A lesion in the trigeminal sensory nucleus leads to sensation loss where?

ipsilateral pain and temperature sensation loss; the trigeminal nuclei have not crossed

Lesions of the trigeminal nucleus in the pons often cause damage to what other tract?

spinothalamic (anterolateral)

Parasympathetics from the facial nerve travel to the geniculate ganglion via what nerve?

nervus intermedius

Where is the facial nucleus located?

in the branchial motor column, more caudally in the pons than the trigeminal motor nucleus

Facial colliculus

elevated area located on the dorsal pons in the floor of the 4th ventricle. It is formed by fibers from the motor nucleus of the facial nerve as they loop over the abducens nucleus.

Upper motor neuron lesions of the corticobulbar tract lead to what deficits?

loss of contralateral face movement; forehead spared

The facial nerve enters the internal auditory meatus with what other nerve?

CN VIII

Geniculate ganglion

lies in the genu and contains primary sensory neurons for taste sensation in the anterior 2/3 of the tongue, and for general somatic sensation in a region near the external auditory meatus

Innervation: Tensor Tympani

Trigeminal

Innervation: Stapedius

Facial Nerve

The chorda tympani joins the ____ nerve to reach the ____ ganglion, where postganglionic parasympathetics arise to supply the submandibular and sublingual salivary glands

lingual nerve; submandibular ganglion

The majority of saliva production is in which glands?

submandibular

Facial nerve parasympathetic pre-ganglionics are found where?

superior salivatory nucleus

After the geniculate ganglion, CN7 pre-ganglionic parasympathetics travel via which nerve?

greater petrossal nerve

Facial nerve parasympathetic post-ganglionics are found where?

(pterygopalatine) sphenopalatine ganglion

Facial nerve exits the skull through the ...

stylomastoid foramen

Nerve to stapedius is innervated by which cranial nerve?

CN7

A patient with hyperacusis and decreased tear production most likely has a lesion within which cranial nerve?

CN7 (facial) controls the lacrimal gland with parasympathetics and the nerve to stapedius to prevent hyperacusis; perhaps this is a Bell's Palsy

How does the facial nerve sense taste?

chorda tympani/lingual nerve transmit taste to the VPM of thalamus

The submandibular ganglion receives pre-ganglionic parasympathetics from which nerve?

facial nerve > lingual nerve

Cranial nerve parasympathetics travel with what fibers in the brain?

branches of the trigeminal nerve (V1, V2, V3)

Lingual nerve is a branch of which cranial nerve?

V3

A patient presents with full right sided face paralysis. Where is the lesion?

left upper motor neuron/lateral motor cortex

The presence of hand weakness, sensory loss, dysarthria, or aphasia suggest an (upper/lower) motor neuron lesion

upper

Crocodile tears

Aberrent regeneration of parasympathetic fibers in which patients experience lacrimation instead of salivation

Corneal reflex afferent limb ...

CN V1 (ophthalmic)

Corneal reflex efferent limb ...

CN 7

Eye blink reflex afferent limb...

CN 2

Eye blink reflex efferent limb...

CN 3

jaw jerk reflex

monosynaptic pathway - mesencephalic trigeminal nucleus

How does sound get processed. Start with the tympanic membrane.

Tympanic membrane > malleus > incus > stapes > oval window > cochlea > scala tympani/vestibuli > round window > spiral ganglion > cochlear nuclei > inferior colliculi > medial geniculate nucleus of thalamus > auditory cortex (Heschel's gyrus)

The superior olivary nucleus receives neurons from ...

ventral cochlear nuclei

Where is the primary auditory complex found?

Heschl's transverse gyrus

In the cochlea, hair cells are found in (endolymph or perilymph)?

endolymph

The hair cells nearest the oval window hear (high or low frequencies)?

high frequencies are heard in the early cochlea

Hair cells in the vestibular system are found in what structure?

crista ampullaris

The medial longitudinal fasciculus connects which 4 cranial nerve nuclei?

3, 4, 6, 8

Brodman's Area 41

primary auditory cortex (Heschl's transverse gyri)

Testing conduction of sound through bone and air is called the ____ test.

RInne

Testing conduction of sound through to each ear simultaneously is called the ____ test.

Weber

Sound is heard better through (air or bone) conduction?

air

An acoustic neuroma is a tumor what cells?

Schwann cells on CN8 > leads to hearing loss, tinnitus and unsteadiness

What is true vertigo?

room spinning due to vestibular problems (PNS or CNS)

Vertigo caused by CNS problems will show what result in a Dix-Hallpike test?

immediate vertigo when semicircular canal is stimulated

Vertigo caused by PNS problems will show what result in a Dix-Hallpike test?

delayed vertigo when semicircular canal is stimulated

what fills the body labyrinth

perilymph

what fills the membranous labyrinth

endolymph

what comprises the membranous labyrinth

cochlear duct, utricle, saccule, semicircular canals

path of vibration in the ear

oval window-scalavestibuli-cochlea/cochlear duct (scala media)-scala tympani-round window

where mechanoreceptor cilia on hair cells are activated by movement of the basilar membrane relative to the stiff tectorial membrane.... these neurons have their cel bodies in the spiral ganglion

cochlear duct (scala media(

hair cells of cochlea + supporting cells =

organ of corti

detects angular acceleration

ampullae of the semicircular canals

detects linear acceleration

maculae of the otolith organs (utricle and saccule)

receives input from the posterior saccule and posterior semicircular canal

inferior vestibular ganglion

receives input from the utricle, anterior saccule, and anterior and lateral semicircular canals

superior vestibular ganglion

where do the four vestibular nuclei lie

lateral floor of 4th ventricle in pons and rostral medulla

which vestibular spinal tract extends throughout the length of the spinal cord and is important in maintaining balance and extensor tone

lateral vestibular nucleus

which vestibular spinal tract extends to only the cervical spine and is important for head and neck position

medial vestibular nucleus

what does the inferior vestibular nucleus look like on myelin stain

checkerboard

what is the pathway that connects the nuclei involved in eye movements to each other and to the vestibular nuclei

medial longitudinal fasciculus

hearing loss caused by disorders of the cochlea or CNVIII

sensorineural hearing loss

hearing loss caused by abnormalities of the external auditory canal or middle ear

conductive hearing loss

in this type of hearing loss, bone conduction is greater than air conduction

conductive hearing loss

in this type of hearing loss, air conduction is greater than bone conduction, however, hearing is decreased in the affected ear

sensorineural hearing lost

tuning fork is placed on vertex of skull in midline, pt is asked which side the tone sounds louder

weber test; sensorineural hearing lost: tone is quieter on affected side
conductive hearing loss: tone is louder on affected side

can be caused by lesions anywhere in the vestibular pathway from labyrinth, to vestibular nerve, to vestibular nuclei and cerebellum, to parietal cortex

vertigo

dix-hallpike positional testing: onset of nystagmus is delayed, there is adaptation, there is horizontal or rotary nystagmus but not vertical

peripheral (inner ear) lesion

dix-hallpike positional testing: onset of nystagmus is immediate, there is no habituation, there is horizontal, rotary, and vertical nystagmus, and nystagmus may occur in absence of vertigo

central (brainstem or cerebellum) lesion

pt has recurrent episodes of vertigo, accompanied by fluctuating and sometimes stepwise, progressive hearing loss and tinnitus. pt also can complain of a feeling of fullness in the ear

meniere's disease

What is the onset of nystagmus in a peripheral (inner ear) lesion?

delayed

What is the onset of nystagmus in a central (brainstem or cerebellum) lesion?

can be immediate or delayed

Is there adaptation (habituation) in a peripheral (inner ear) lesion?

yes

Is there adaptation (habituation) in central (brainstem or cerebellum) lesion)

no

What are the characteristics of nystagmus and vertigo in a peripheral (inner ear) lesion?

Horizontal or rotatory, not vertical; does not change directions; prominent nystagmus only if vertigo is present as well

What are the characteristics of nysagmus and vertifo in a central (brainstem or cerebellum) lesion affecting CN VIII?

Horizontal, rotatory, or vertical; may change directions; prominent nysagmus may occur in the absence of vertigo

Benign paroxysmal positional vertigo

most common cause of true vertigo; patients experience brief episodes of vertigo lasting a few seconds and changing with position; proposed mechanism = otoconia (otholtihic debris in the semicircular canals)

CN 9 Motor fibers arise from what nucleus?

nucleus ambiguous

CN 9 Pre-ganglionic parasympathetic fibers arise from what nucleus?

inferior salivatory nucleus

CN 9 Post-ganglionic parasympathetic fibers arise from what ganglion?

otic ganglion

Parotid gland innervation comes from which nerve?

CN 9 > lesser petrossal > auriculotemporal (V3)

The carotid sinus and carotid body send sensory information via which nerve?

CN 9

afferents IX which conveys inputs from baroreceptors and chemic receptors from the carotid body synapse in what nucleus

caudal nucleus solitarius of the medulla

taste from IX which does the posterior 1/3 of the tongue synapses in what nucleus

rostral nucleus solitarius (gustatory nucleus)

what muscle does the branchial motor portion of CNIX supply

stylopharyngeus (elevates pharynx during talking and swallowing and contributes with XNX to gag reflex)

where do parasympathetic preganglionic fibers in the glossopharyngeal nerve originate and what do they exit as

inferior salivatory nucleus in the pons..they leave the glossopharyngeal nerve via the tympanic nerve and then join the lesser petrosal nerve to synapse in the otic ganglion-->providing postganglionic parasympathetics to the parotid gland

afferents IX which conveys inputs from baroreceptors and chemic receptors from the carotid body synapse in what nucleus

caudal nucleus solitarius of the medulla

Parasympathetic pre-ganglionic fibers of CN10 are found where?

Dorsal motor nucleus of CN10

The taste nucleus is part of what larger nucleus? What Cranial nerves send sensation to it?

nucleus solitarus; CN 7, 9, 10

Contraction of the left SCM muscle turns the head which direction? Left SCM tilts the head to which side?

turns it right; tilts it left

A lesion in the left tongue motor cortex will produce weakness on which side?

contralateral, right

A lesion in the left tongue hypoglossal nucleus will produce weakness on which side?

ipsilateral, left

A lesion in the left tongue motor cortex will cause the tongue to deviate to which side when protruded?

right. left motor cortex = right sided hypoglossal nerve damage = tongue protrusion deviates it to the right since the left pushes forward more

A lesion of the left hypoglossal nerve will cause the tongue to deviate to which side when protruded?

left. the right hypoglossal will protrude more and push the tongue left

Larynx muscles are innervated by ...

CN10

Hoarse voice suggests damage to which cranial nerve?

CN 10

Difficulty swallowing can be caused by damage to which cranial nerves?

9, 10 &12

Gag reflex afferent limb

CN 9

Gag reflex efferent limb

CN 10

A patient's uvula deviates to the left. Which nerve is damaged?

right CN 10

A patient's soft palate is lower on the left. Which nerve is damaged?

left CN 10; curtain sign""

what nucleus supplies the motor component of CNX

nucleus ambiguus

nerve that loops back upward from the thoracic cavity to control all intrinsic laryngeal muscles except for the cricothyroid

recurrent laryngeal nerve

innervation of cricothyroid

superior laryngeal nerve

lower part of traps are innervated by

C3 and C4

where does CNXII exit

between the pyramid and inferior olivary nucleus

lesions in the primary motor cortex or internal capsule will cause ______ tongue weakness...lesions of the hypoglossal nucleus or nerve will cause ____ tongue weakness

lesions in the primary motor cortex or internal capsule will cause contralateral tongue weakness...lesions of the hypoglossal nucleus or nerve will cause ipsilateral tongue weakness

unilateral tongue weakness will cause the tongue to deviate toward the weak side when it is protruded. Therefore a lesion of the hypoglossal nerve will cause the tongue to deviate away/toward the side of the lesion

toward the side of the lesion

glomus tumors

result in compression of IX, X, XI in the jugular foramen

abnormal articulation of speech

dysarthria.. it should be distinguished from aphasia

difference between dysarthria and aphasia

dysarthria: motor articulatory disorder; aphasia: disorder or higher cognitive function in which language formulation or comprehension is abnormal

impaired swallowing

dysphagia

gag reflex afferent and efferent

afferent; mostly ix --- efferent; mostly x

what causes this: when the uvula and soft palate deviate to the normal side and the abnormal soft palate hangs low

unilateral lesions of CNX or the nucleus ambiguus (stage curtain sign)

lesions in what cranial nerves will cause random laughter or crying without feeling the usual associated emotions

CN VII, IX, X, XII...lesions of the corticobulbar pathways (pseudobulbar affect)

difference in sensory innervation of middle and outer ear

middle ear: IX; outer ear: V3, VII, IX, X

muscles of the soft palate are supplied by...except...

muscles of the soft palate are supplied by X except for tensor veli palatini (V3)

sensation from the supratentorial dura mater is carried by..

CNV

while dura of the posterior cranial fossa is supplied by...

CNX

To walk down stairs, one has to have the ability to move the eyes down when they are in the medial position. This involves the use of cranial nerve _______, which innervates the superior oblique muscle (whose action is to pull the eye downward when in the medial position).

If there is damage to this nerve on one side, the eyes will not be able

to focus on the same visual field, thus producing double vision.

IV (trochlear nerve)

patient has a stroke and is rigid aftewards. Where is the lesion and what produces the rigidity

pons... unopposed action of the lateral vestibulospinal tract; The central pathways mediating taste include the following: primary afferent
taste fibers associated with taste receptors of cranial nerves VII, IX, and X

synapse in the _____ nucleus.

the solitary nucleus

CNIX supplies the stylopharyngeous muscle (elevation of pharynx in speech)... what nucleus supplies its efferents

nucleus ambiguus