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30 Cards in this Set
- Front
- Back
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GnRH neurons orginate where
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Oustide CNS, they migrate to hypothalamus during development
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How is GnRH released?
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In a pulsatile pattern
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1 GnRH pulse/hr favors
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LH Secretion
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Theca cells respond to what hormone in Follicular phase
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LH
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Theca cells produce what during follicular phase
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Androstenedione (b/c they have 17-OH)
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Granulosa cells respond to what hormone during follicular phase?
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FSH
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Granulosa cells make what hormone during follicular phase?
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Estradiol (using aromatase and androstendione)
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Granulosa cells will develop what receptor during follicular phase and increase what hormone?
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LH, Estradiol
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Inhibins are produce by which cells and inhibit what?
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Granulosa and luteal cells
- FSH |
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AMH is produced by which cells and do what?
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Granulosa cells that are more developed
Restrain growth of primordial/primary follicles |
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Increasing estradiol concentrations during follicular development inhibit
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FSH
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LH surge triggers what
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Ovulation and formation of corpus luteum
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During the luteal phase the theca cells make what
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Progesterone
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During the luteal phase the granulosa cells make
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Progesterone
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Which layer of the uterus builds up?
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Stratum fuctionale
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What does estradiol do to breasts?
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Prolifeartion of epithelium and development of ducts
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What does progesterone do to breasts?
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Cause duct branching and proliferation of alveoli
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Prolactin does what to breasts?
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Stimulate milk production
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What does oxytocin do to the breasts?
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Promote milk secretion
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What does progesterone do to the cervix?
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Decrease mucous production
Makes viscous mucous |
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What does estradiol do to the cervix?
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Increase mucous production
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Midcycle estrogen has what effect on anterior pituitary?
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Positive
LH surge occurs |
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Ovarian hyperstimulation sydrome occurs with some women who do
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IVF
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What causes ovarian hyperstimulation syndrome?
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hCG treatment
causing increased premebility in capillaries in ovary |
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Children who are born in vitro are at risk for these 2 syndromes
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Angelman
Beckwith-widemann |
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Which two hormones are increased in PCOS?
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LH
Androgens |
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What is the gross presentation of PCOS?
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String of pearls
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What is the principle abnormality in PCOS?
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Theca cell androgen production
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How do women with PCOS develop insulin resistance?
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Increase in viseral fat deposition and FFA
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What is the signaling defect in PCOS relating to insulin?
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defect due to serine phosphorylation of insulin receptor and IRS-1 which decreases PI3-K and resistance to insulin
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