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22 Cards in this Set
- Front
- Back
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ATN acciciated with heavy metals...
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tubular necrosis is due to
1.damage to membranes of PCT cells 2. mitochondrial damage by the interaction of metals with the SH proteins |
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Cisplatin
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causes tubular necrosis bu
1. direct damage 2. reducing renal blood flow by vasoconstriction |
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Aminoglycosides...
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neomycin, gentamycin, amikacin
1. drugs escape into the cytoplasm 2. alter cell membrane transport 3. inhibit cell organelle functions 4. cause shedding of brish border and cellular death |
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Mycotoxins produced by Aspergillus or Penicillin...
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ATN followed by diffuse renal fibrosis
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oak...
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tubular necrosis in ruminants
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ATN due to Oxalates...
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metabolites of ethylene glycoh cause formation of Ca oxalate crystals in tubular lumen
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ATN and vitamin D...
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too much vit D causes hypercalcemia, tubular absorption of Ca and vasoconstriction, mitochondrial calcification followed by cell death
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Epsilon exotoxin...
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produced by C. perfringens type D in small ruminants
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Cause of Pulpy Kidney disease...
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Epsilon exotoxin
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Results of Pulpy Kindey Disease...
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ATN
interstitial edema hemorrhage Needs to be differentiated from posr mortem autolysis |
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Interstitial nephritis...
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primary inflammation in intertitial vascular stuctures or CT
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Tubulointerstitial nephritis broad definition...
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A group of inflammatory diseases involving interstitium and tubules
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Characteristics of Acute Tubulointerstitial disease...
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ATN
Papillary necrosis Interstitial inflammation |
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Causes of Acute Tubulointerstitial disease...
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Leptopira,
E.coli Herpes Adenovirus |
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Characteristics of Chronic Tubulointerstitial disease...
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Tubular atrophy
Glomerular atrophy fibrosis |
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Cause of Chronic Tubulointersitial disease...
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Secondary to GN or pyelonephritis
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Best example of bacterial tubulointerstitial nephritis...
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Leptospirosis
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Acute Lepto lesions...
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Tubular necrosis
No inflammation |
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Chronic Lepto lesions...
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Interstitial lymphaplasmacytic infiltrates
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Granulomatous Nephritis...
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Tubulointerstitial disease often accompanying a syatemic disease
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Etiology of Granulomatous Nephritis...
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FIP
Mycobacterium Hairy Vetch in cows |
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Diseases of the Renal Pelvis...
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Pyelonephritis
Hydronephritis |
