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22 Cards in this Set

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ATN acciciated with heavy metals...
tubular necrosis is due to
1.damage to membranes of PCT cells
2. mitochondrial damage by the interaction of metals with the SH proteins
Cisplatin
causes tubular necrosis bu
1. direct damage
2. reducing renal blood flow by vasoconstriction
Aminoglycosides...
neomycin, gentamycin, amikacin
1. drugs escape into the cytoplasm
2. alter cell membrane transport
3. inhibit cell organelle functions
4. cause shedding of brish border and cellular death
Mycotoxins produced by Aspergillus or Penicillin...
ATN followed by diffuse renal fibrosis
oak...
tubular necrosis in ruminants
ATN due to Oxalates...
metabolites of ethylene glycoh cause formation of Ca oxalate crystals in tubular lumen
ATN and vitamin D...
too much vit D causes hypercalcemia, tubular absorption of Ca and vasoconstriction, mitochondrial calcification followed by cell death
Epsilon exotoxin...
produced by C. perfringens type D in small ruminants
Cause of Pulpy Kidney disease...
Epsilon exotoxin
Results of Pulpy Kindey Disease...
ATN
interstitial edema
hemorrhage
Needs to be differentiated from posr mortem autolysis
Interstitial nephritis...
primary inflammation in intertitial vascular stuctures or CT
Tubulointerstitial nephritis broad definition...
A group of inflammatory diseases involving interstitium and tubules
Characteristics of Acute Tubulointerstitial disease...
ATN
Papillary necrosis
Interstitial inflammation
Causes of Acute Tubulointerstitial disease...
Leptopira,
E.coli
Herpes
Adenovirus
Characteristics of Chronic Tubulointerstitial disease...
Tubular atrophy
Glomerular atrophy
fibrosis
Cause of Chronic Tubulointersitial disease...
Secondary to GN or pyelonephritis
Best example of bacterial tubulointerstitial nephritis...
Leptospirosis
Acute Lepto lesions...
Tubular necrosis
No inflammation
Chronic Lepto lesions...
Interstitial lymphaplasmacytic infiltrates
Granulomatous Nephritis...
Tubulointerstitial disease often accompanying a syatemic disease
Etiology of Granulomatous Nephritis...
FIP
Mycobacterium
Hairy Vetch in cows
Diseases of the Renal Pelvis...
Pyelonephritis
Hydronephritis