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8 Cards in this Set
- Front
- Back
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Cortical Collecting Tubule |
-Principle Cells: Regulate Na+/H2O reabsorption via ENaC -Intercalated cells: Control Acid/Base balance via Bicarbonate absorption. Response to Aldosterone -Principal Apical: ENaC (Na+ in, K+ out) Amiloride -Basolateral: ATPase (NA+/K+) -CCT, target of K+ sparing diuretics |
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Aldosterone |
-mineralocorticoid (steroid hormone) -Secreted by adrenals -Increase ATPase (Na+/K+ basolateral side) -Increases Na+/H2O reabsorbtion -Addison's Disease: Aldosterone deficiency |
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ADH or Arginine Vasopressin |
-Vasoactiv peptide secreted by posterior pituitary -Activates ADH receptor on Vasculature -Constricts Periph Vasculature -Promotes Water Reabsorption in CCT -CCT not water permeable w/o ADH
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Loop Diuretics/Thiazide Waste K+ |
-Increase Na+ deliver to CCT increases secretion of K+ and H+ by CCT -Hypokalemic Metabolic Alkylosis -K+ loss |
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Potassium Sparing Diuretics -Amiloride |
-Direct inhibitor of ENaC -Preserve cardiac function -Prevent HF -Hyperkalemia -Acidosis |
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Potassium Sparing Diuretics -Spironolactone |
-Synthetic steroid -->interferes w/ aldosterone -Reduces Na+ reabsorption by reducing ATPase expression -Prevent HF -Preserve Cardiac function -Hyperkalemia -Acidosis -Gynecomastia |
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ADH receptor agonists -Vasopressin/Desmopressin |
-Act as antidiuretic just like ADH -Treat pituitary diabetes insipidus -Toxic: monitor for water toxicity |
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ADH receptor antagonists - Conivaptan |
-Inhibits vasopressin ADH -Hypertension -HF -Counteract high ADH in SIADH -Infusion site reactions/hypernatremia |
