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Cortical Collecting Tubule
-Principle Cells: Regulate Na+/H2O reabsorption via ENaC
-Intercalated cells: Control Acid/Base balance via Bicarbonate absorption. Response to Aldosterone
-Principal Apical: ENaC (Na+ in, K+ out) Amiloride
-Basolateral: ATPase (NA+/K+)
-CCT, target of K+ sparing diuretics
Aldosterone
-mineralocorticoid (steroid hormone)
-Secreted by adrenals
-Increase ATPase (Na+/K+ basolateral side)
-Increases Na+/H2O reabsorbtion
-Addison's Disease: Aldosterone deficiency
ADH or Arginine Vasopressin
-Vasoactiv peptide secreted by posterior pituitary
-Activates ADH receptor on Vasculature
-Constricts Periph Vasculature
-Promotes Water Reabsorption in CCT
-CCT not water permeable w/o ADH
Loop Diuretics/Thiazide Waste K+
-Increase Na+ deliver to CCT increases secretion of K+ and H+ by CCT
-Hypokalemic Metabolic Alkylosis
-K+ loss
Potassium Sparing Diuretics -Amiloride
-Direct inhibitor of ENaC
-Preserve cardiac function
-Prevent HF
-Hyperkalemia
-Acidosis
Potassium Sparing Diuretics -Spironolactone
-Synthetic steroid -->interferes w/ aldosterone
-Reduces Na+ reabsorption by reducing ATPase expression
-Preserve Cardiac function
-Gynecomastia
ADH receptor agonists -Vasopressin/Desmopressin
-Act as antidiuretic just like ADH
-Treat pituitary diabetes insipidus
-Toxic: monitor for water toxicity
ADH receptor antagonists - Conivaptan
-Inhibits vasopressin ADH
-Hypertension
-HF
-Counteract high ADH in SIADH
-Infusion site reactions/hypernatremia
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