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9 Cards in this Set
- Front
- Back
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the T-cell maturation/ontogeny is antigen... |
independent |
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location of T cell ontogeny and differentiation |
ontogeny-bone marrow |
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as T cells differentiate in thymus |
gene rearrangement of the T cell antigen-receptor (TCR) genes and expression of either CD4 or CD8 proteins |
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what genes encode the light chain? |
light chain- alpha;IGL |
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list the time order in which beta genes (VH, C) of T cells are rearranged |
DJ, VDJ, VDJC |
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in what order are the light chain alpha genes rearranged? |
VJ then VJC, encoding TCR alpha chain |
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during t cell maturation |
the thymocyte is also arranging its CD3,CD4, and CD8 genes in order to transcribe and express these cell-surface molecules. At this stage of thymocyte maturation, CD4- and CD8- are not yet expressed and these thymocytes are called “double negatives”. |
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the antigen independent and dependent phases of B cells |
antigen independent phase- b cell maturation/ontogeny |
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explain antigen independent phase of b cells |
hematopoetic stem cell stage (HSC) in the bone marrow -> blast cell formation-> (a cell preparing for cell division/proliferation)-> pro-B cell-> pre-B cell->immature B cell->mature B cell |
