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the T-cell maturation/ontogeny is antigen...the T-cell differentiation into effector memory T cell is antigen...
independentdependent
location of T cell ontogeny and differentiation
ontogeny-bone marrowdifferentiation - thymus
as T cells differentiate in thymus
gene rearrangement of the T cell antigen-receptor (TCR) genes and expression of either CD4 or CD8 proteins
what genes encode the light chain?heavy chain?
light chain- alpha;IGLheavy chain- beta;IGH, with beta occuring first
list the time order in which beta genes (VH, C) of T cells are rearranged
DJ, VDJ, VDJCthis sequence encodes the TCR beta chain
in what order are the light chain alpha genes rearranged?
VJ then VJC, encoding TCR alpha chain
during t cell maturation
the thymocyte is also arranging its CD3,CD4, and CD8 genes in order to transcribe and express these cell-surface molecules. At this stage of thymocyte maturation, CD4- and CD8- are not yet expressed and these thymocytes are called “double negatives”.
the antigen independent and dependent phases of B cells
antigen independent phase- b cell maturation/ontogenyantigen dependent phase - b cell differentiation into memory and plasma cells
explain antigen independent phase of b cells
hematopoetic stem cell stage (HSC) in the bone marrow -> blast cell formation-> (a cell preparing for cell division/proliferation)-> pro-B cell-> pre-B cell->immature B cell->mature B cell
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