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59 Cards in this Set
- Front
- Back
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AMG + Cyclosporine
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nephrotoxicity
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AMG + Amphotericin B
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nephrotoxicity
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AMG + NSAIDs
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nephrotoxicity
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AMG + radiographic contrast
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nephrotoxicity
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AMG + vancomycin
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nephrotoxicity
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AMG + ether
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increase apnea or respiratory paralysis
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AMG + neuromuscular blocking agents, non-polarizing muscle relaxants
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increase apnea or respiratory paralysis
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Metronidazole + alcohol
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disulfuram-like reaction
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Metronidazole + disulfuram
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acute toxic psychosis
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Metronidazole + oral anticoagulant
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increase anticoagulant effect
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Metronidazole + hydantoin, phenytoin
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increase Met metabolism (decrease effect)
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Chloramphenicol + Hydantoin
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increase in hydantoin effect, toxicity, nystagmus, ataxia
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Chloramphenicol + Iron salts, vitamin B12
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decrease in vitamin/iron response
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Chloramphenicol +Oral anticoagulants
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increase in prothrombin time
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Chloramphenicol + sulfonylureas
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Increase in sulf effect (hypoglycemia)
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Clindamycin + Kaolin
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decrease in absorption of Clindamycin
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Amphotericin B deoxycholate (Fungizone) + Adrenocorticoids
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Hypokalemia
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Amphotericin B + AMG, cyclosporine
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nephrotoxicity
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Amphotericin B + Digitalis
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increase in digitalis toxicity secondary to hypokalemia (d/t amphotericin)
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Fluconazole + non-sedating antihistamine, Cisapride
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increase levels of antihistamine --> cardiac arrhythmias
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Fluconazole + cyclosporine, tacrolimus
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increase levels of cyclosporine, tacrolimus
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Fluconazole + oral hypoglycemic
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increase levels of oral hypoglycemic
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Fluconazole + BZDs
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Increase effects of BZDs
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Fluconazole + oral anticoagulants
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Increase effects of oral anticoag
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Fluconzaole + hydantoin
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increase hydantoin; decrease fluconazole, itraconazole, ketoconazole
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Fluconazole + Rifampin/rifabutin
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decrease fluconazole, itraconazole, ketoconazole
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Fluconazole + isoniazid
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decrease fluconazole, itraconazole, ketoconazole
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Fluconazole + Didanosine
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decrease absorption of itraconazole, ketoconazole
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Fluconazole + H2 blockers, antacids
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decrease absorption of itraconazole, ketoconazole
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Cephalosporin + oral anticoagulants, heparin, platelet aggregation inhibitors, thrombolytic agents
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increase effects of blood thinner --> bleeding
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Cefmandole, Cefoperazone + alcohol
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Disulfuram-like reaction
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Imipenem/Cilastatin + Ganciclovir
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Seizures
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Vancomycin + non-depolarizing muscle relaxants
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increase neuromuscular blockade
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Erythromycin + Carbamazepine
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increase serum levels of CBZ, nystagmus, nausea, vomiting, ataxia
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Erythromycin + corticosteroids
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increase serum levels of corticosteroid
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Erythromycin + cyclosporine, tacrolimus
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increase levels of cyclosporine, tacrolimus
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Erythromycin + digoxin
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increase levels of digoxin
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Erythromycin + theophyllines
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increase levels of theophylline, N/V, seizures, apnea
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Erythromycin + terfenadine, astemizole
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increase cardiotoxicity
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Penicillin G + Cholestyramine/Colestipol
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decrease absorption of penicillin
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Tetracycline + digoxin
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increase digoxin toxicity
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Tetracycline + methoxyllurane
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increase toxicity, polyurea, renal failure
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Tetracycline + Sucralafate
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decrease tetracycline absorption
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Ampicillin (& Methicillin) + allopurinol
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increase in rash frequency
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Ampicillin + beta blockers (atenolol)
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decrease in absorption of b-blockers
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Piperacillin + Cefoxitin
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antagonize pseudomonas aeruginosa
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Piperacillin + vecuronium
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increase in neuromuscular blockade
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Ciprofloxacin/Ofloxacin + Cimetidine
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increase levels of quin (decrease renal CL)
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Ciprofloxacin/Ofloxacin + Didanosine
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decrease absorption of quinolones
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Ciprofloxacin/Ofloxacin + multivalent metallic cation (Al, Ca, Fe, Mg, Zn)
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decrease absorption of quinolones
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Cipro + theophylline
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increase theo levels
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Cipro + caffeine
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increase caffeine levels
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Cipro + antacids, sucralafate
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decrease cipro levels
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Doxycycline + Aluminum, Bismuth, Fe, Mg salt, sucralafate
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decreases doxycycline absorption
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Doxycycline + barbiturates
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decrease serum 1/2 of doxy
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Doxycycline + CBZ
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decrease serum 1/2 of doxy
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Doxycycline + hydantoin
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decrease serum 1/2 of doxy
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Doxycycline + Digoxin
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increase serum levels of digoxin --> increase toxicity
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Doxycycline + methoxyfurane (general anesthetic)
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increase toxicity, polyuria, renal failure
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