Drug Interactions

Front 1

Drug that interacts with ca, fe and aluminium salts

Back 1

Site 1 drug.

Tetracycline (antibiotic)

Front 2

Drug that interacts with warfarin, thyroxine and digoxin

Back 2

Site 1 drug

Cholestyramine (cholesterols reducing agent)

Front 3

Drugs that increase Gastic emptying

Back 3

Site 1 Metioclopramide and dompridone

These drugs decrease DIGOXIN as it normally absorbed in the stomach

And

Increase TETRACYLINE as it’s normally absorbed in the small intestine

Front 4

Drug that reduce gastric emptying

Back 4

Site 1 Opioid alagesics (morphine)

Some anti depressants

Increase absorption in stomach and decrease small intestine absorption

Front 5

Name an anti epileptic and anti convulsants that you can take together

Back 5

Site 2 Phenytoin (antiE) and sodium valproate (antiC)

Phenytoin toxicity

Front 6

Drug for heart failure and anti arrhythmia you can’t take together

Back 6

Site 2 Digoxin (heart failure)

And

Quinidine

Digoxin toxicity

Front 7

Drugs that increase metabolism

Back 7

Site 3 - Barbiturate (anaesthetic and antiepiletic )

Phenytoin ( antiE)

CarbMazepine (anti E)

Rifampicin (TB or leprosy )

Will reduce conc of those drugs that are metabolised by that particular p450

Front 8

Drug that decrease metabolism

Back 8

Site 3

Erythromycin ( antibiotic )

Quinolone Antib

Cimetidine (anti histamine )

Ketoconazole (anti fungal)

Fluoxetine ( antiD)

Front 9

Enzyme inhibitors in food

Back 9

Grapefruit juice (inhibitors cyp3a4 isoform)

Potentially inhibits

Carbamazepine

Buspirone

Ciclosporin

Dihydropyridine

Front 10

Example of a drug you’d inhibitors deliberately

Back 10

Levodopa —-> dopamine

Inhibited by peripheral decarboxylase inhibitors, carbidopa, benserazide with Levodopa

Increase dopamine conc

Front 11

Drugs that can cause toxicity to food constituents

Back 11

Tyramine —-> 4-hydroP Acid

Non selective Moa inhibitors: tranylcypromine and phenelzine (antiD)

Front 12

Beta pharmacodynamic interactions

Back 12

B2 agonist for asthma and non selective B antagonist (hypotension)

Front 13

Hypotension drugs that you need to be aware of

Back 13

Ace inhibitor and ca2 channel blocker (nifeedipine, diltiazem and verapamil)

Front 14

Two drugs interaction which can cause sever CNS stimulation

Back 14

Selective serotonin reuptake inhibitors (fluoxetine) and MAO inhibitors (phenelzine, tranylcypromine)

Front 15

Two drug that interact to cause ototoxicity

Back 15

Aminoglcoside antiB (streptomycin and kenamycin)

Loop diuretic (frusemide and bumetanide)