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17 Cards in this Set
- Front
- Back
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Parenteral Preparations:
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Iron Dextran Inj (DEXFERRUM): BE CAREFUL WITH ANAPHLASIX
Iron Sucrose complex (VENOFER) Sodium Ferric gluconate complex (FERRLECIT) |
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Oral Preparations:
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Ferrous Sulfate (FEOSOL)
Ferrous Fumarate (FERGON) Ferrous Gluconate (FEMIRON) |
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Oral Preparations:
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1. should be taken on empty stomach
2. Food decrease iron absorption 3. 1 hr before or 3 hours after antacids. |
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Iron binds to
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antibiotics prevent absorption.
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Iron poisoning (
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necrotizing gastroenteritis
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tx of iron poisoning
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Acute: Deferoxamine (iron chelator)
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CHRONIC Iron Overload: hemochromatosis: pt who inherited or many red cell transfusions.
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tx: intermittent phlebotomy (remove blood)
severe: phlebotomy + deferoxamine. |
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NEW IRON CHELATOR:
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Deferasirox (EXJADE)
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Deferasirox (EXJADE):
chronic iron overload due to transfusions |
HIGHLY PROTEIN BOUND
ORALLY ACTIVE EXCRETION: FECES SELECTIVE: FERRIC IONS |
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A.E. Deferasirox
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Pancytopenia
Kidney, Hepatic Toxicity Auditory and Ocular disturbances. |
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MEGALOBLASTIC ANEMIA
MORPHOLOGICALY MACROLYTIC-LARGE CELLS |
FOLIC ACID AND V12 DEF.
hematologic defic: folic and v12 Neurological def: v12 |
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ADMINISTRATION OF FOLIC ACID ALONE CAN CORRECT:
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- hematological sx but NOT neurological problem.
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Common causes of VB12
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- PERNICIOUS ANEMIA (defective secretion of intrinsic factor)
- gastrectomy - malabsorption - IBD - Small Bowel REsection - Decreased intake. |
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Causes of folic acid def.
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1. liver disease
2. alcoholics 3, preg. 4. Cancer Drug 5. Myeloproliferative disorders 6. Kidney dialysis 7. Lack of dietary intake |
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Drugs CAUSE folate def.
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1. phenytoin
2. primidone 3. oral contraceptives 4. para-amino salicylate 5. sulfasalzien |
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Erythropoietin
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in response to hypoxia
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darbopoietin better half - life
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CI UNCONTROLLED HYPERTENSION
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