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6 Cards in this Set
- Front
- Back
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How does Na/KATPase work? |
Transporter has high affinity for Na+ ions inside cell, 3 Na+ ions bind to binding sites, transporter hydrolyses ATP and becomes phosphorylated, conformational change occurs, affinity for Na+ decreases so they are released, affinity for K+ ions inceases, 2 K+ions binf to binding sites, transporter becomes dephophorylated, conformational change occurs, affinity for K+ decreases and they are released inside the cell |
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What is Na/KATPase used for? |
Maintaining osmotic balance in animal cells, maintaining and generating ion gradients for resting potential in neaurons, generating ion gradient in kidney tubules, and generating ion gradient for glucose symport |
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What is resting potential? |
Imbalance in electrical charge across the membrane of a neuron |
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What is nerve transmission? |
A wave of depolarisation of the resting potential |
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How is depolarisation of the resting potential triggered? |
Neurotransmitter binds to receptor protein, ligand gated channel opens so Na+ ions diffuse into neuron, sufficient Na+ movement causes depolarisation, critical level of depolarisation is reched, voltage gated channel to open to diffuse neuron |
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How is resting potential reset? |
Na+ voltage gated channels close, voltage gated K+ channels open, K+ ions diffuse in opposite direction, once resting potential is reached, K+ channel closes again |
