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16 Cards in this Set
- Front
- Back
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Neuronal Function |
1. information input 2. decolonisation 3. action potential generation & direction of propagation 4. neurotransmitter release |
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Cell membrane potential |
1. membrane more permeable to K+ than Na+ 2. electrical forces opposes K+ outflow & favours Na+ inflow 3. resting membrane potential develop 4. Na+/K+ pump maintain |
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Nernst equation |
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Leak channels |
open most of the time. K+ leak channel regulate membrane potential. Na+ leak channel generate unstable membrane potential |
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Gated channel |
closed most of the time. open on activation. |
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Voltage-activated channels |
open/Close due to the binding of a chemical (agonist/cAMP/cGMP/H+) |
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Mechanically-activated channel |
open/Close due to a mechanical stimulus |
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Local Potential |
1. small & confined to a local region of membrane. 2. potential dissipates. 3. size dependant |
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Action potential |
1. stimulus large enough = threshold reached. 2. voltage-gated Na+ channel open. Na+/K+ pulp restores system |
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Propagation along a neuron |
1. negatively charged inner cell membrane. 2. nerve impulse = movement of +ve ions. 3. +very ions move outside the membrane 4. +very ions enter next segment of axon. |
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Transmission across a synapes |
1. Membrane potential 2. Local potential 3. Action potential 4. Propagation along the neuron |
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Local Anasthetic |
prevent Na+ gated channels opening (neurotransmission decrease) |
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Anthicholinesterase Drug |
neurotransmission increased |
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Potassium channel blockers |
neurotransmission increased |
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Neuromuscular Blocker |
complete with acetylcholine D-Tubocurare competitive drug |
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Strychnine |
Competes with glycine - an inhibitory neurotransmitter. (poisoning = tremor, twitching) |
