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21 Cards in this Set

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Ischemic heart disease

No enough oxygen to the heart muscle

Causes of ischemic heart disease

1)Atherosclerosis (in coronary artery ———2)severe anemia 3)Carbon monoxide (high affinity to haemoglobin than oxygen 4) Vado-spastic 5)drugs(cocaine)

How cocaine effects generally

Cocaine inhibits neurotransmitter reuptike mechanism so neuroepinephrine will stimulate sympathetic nervous system and severe vasoconstriction and stroke and acute mi

amphetamine

Heptagon. Increases releases of neuroepinephrine causes euphoria.

Atherosclerosis formation

Endothelial injury


LDL


LDL oxidation will trigger immune cell and macrophages will come (foam cells ) and then smooth cell proliferation will begin and forms(((((()plague))))))

Risk factors of ischemic heart disease

Risk factors of ischemic heart disease?

Modifiable


1)Hypertension


(Endothelial injury )(increasing demand by hypertrophying ventricles


2)hyperlipidimias(ldl)


3)diabetic (lypolysis)


4)smoking(oxygen stress oxidant)


Non modifiable


1)age


2)male


3)family history


My be female after menabosal


Stable angina

Atherosclerosis


Starts second decade of life


Symptoms appear when 70%of artery is occluded


Symptoms with exertion (bcz the heart rate and the contraction will increase and the myocytes need more blood


(Chest pain increased by exertion and relieved by rest and nitrates)

Stable angina

Atherosclerosis


Starts second decade of life


Symptoms appear when 70%of artery is occluded


Symptoms with exertion (bcz the heart rate and the contraction will increase and the myocytes need more blood


(Chest pain increased by exertion and relieved by rest and nitrates)

How nitrates work

Cause vasodilation for venous and decreases after load decrease of stretch decrease contractility




Non modifiable risk factors

Gender male


Family history


Old

Acute coronary syndrome

Rapture of atheroma


And platelets will aggregate


And cause total or subtotal obstruction

Acs

ECG (nstemi) subendocardial infraction /or just ischemia


Non modifiable risk factors

Gender male


Family history


Old

Acute coronary syndrome

Rapture of atheroma


And platelets will aggregate


And cause total or subtotal obstruction

Acs

ECG (nstemi) subendocardial infraction /or just ischemia


Unstable angina

ChestPain more 20-minutes


And doesn’t have a relation with exertion

Non modifiable risk factors

Gender male


Family history


Old

Acute coronary syndrome

Rapture of atheroma


And platelets will aggregate


And cause total or subtotal obstruction

Acs

ECG (nstemi) subendocardial infraction /or just ischemia


Unstable angina

ChestPain more 20-minutes


And doesn’t have a relation with exertion

Acs

Just Ischemia( no cardiac enzymes nor change in in ECG


Subendocardial (no ECG changes but troponin is high


Infraction( ecg changes and cardiac enzymes will come