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12 Cards in this Set
- Front
- Back
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Pimobendan
MOA |
1) Peripheral vasodilation by:
---Inhibits phosphodiesterase III ---suppress cAMP degradation ---cAMP causes vasodilation 2) Decreased pressure 3) Smaller cardiac preload/afterload 4) increases binding to cardiac myofibrin to Ca+ |
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Pimobendan
- absorption - metabolism - bioavailability |
- orally
- in liver to active metabolite - 60-65% |
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Pimobendan
- plasma protein binding - excretion |
- 90-95%
- bile |
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Pimobendan
side effect(s) |
vomiting in dogs
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Digitalis glycosides
MOA |
- inhibits Na/K ATPase
- increases intracellular Na and Ca - increases heart contractility |
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Digitalis glycosides
side effects |
- atrial and ventricular fibrillation
- complete heart block - GI - CNS |
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Digitalis glycosides
what does it do? |
- improves contractility and output
- increases injection fraction - overall parasympathetic effect |
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which Digitalis glycoside drug is most widely used?
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Digoxin
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Digoxin
- absorbed - metabolized - excreted |
- orally
- liver - bile |
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Digitalis
high or low therapeutic index? |
Very LOW therapeutic index
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How to treat digitalis intoxication?
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- Phenytoin (for AV block)
- Lidocaine (ventricular arrhythmia) |
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Digitalis
used for right or left sided HF? |
ONLY LEFT HF
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