Inhibitors Of Dna Replication

Front 1

Drugs that inhibit folate manufacture of folate utilization?

Back 1

ANTI-FOLATES

Front 2

Drug used as part of the TX for toxolasmosis and alt. agent for prophylaxis of pneumocystis and toxoplasma?

Back 2

Pyrimethamine

Front 3

One of the DOC for TX and prophylaxis of pneumocystis?

Back 3

Trimethoprim

Front 4

DOC for the empiric therapy of UTIs in the outpatient population?

Back 4

Trimethoprim and Sulfamethoxazole

Front 5

Sulfa antibiotics (3)

Back 5

sulfadiazine
sulfisoxazole
sulfamethoxazole

Front 6

Those drugs that inhibit purine and pyrimidine synthesis indirectly by inhibiting folate manufacture cause what type of anemia?

Back 6

Type of macrocytic anemia known as megaloblastic anemia

Front 7

6-mercaptopurine is used in the treatment of which leukemia?

Back 7

ALL ( acute lymphocytic leukemia )

Front 8

6-mercaptopurine is converted to thio-IMP with which enzyme?

Back 8

HGPRT

Front 9

Drug that acts as a pyrimidine antagonist and used especially for non-lymphocytic leukemia?

Back 9

Cytarabine

Front 10

This inhibits thymidine synthesis?

Back 10

Fluorouracil (5-FU)

Front 11

Drugs discovered to be cytotoxic to human cells and therefore useful in the TX of CA?

Back 11

antibiotic cytotoxins

Front 12

At higher doses this drug inhibits DNA synthesis and at low doses it interferes with transcription?

Back 12

Actinomycin D (dactinomycin)

Front 13

This drug created radical oxygen species and decreases IP3 coupled transport processed?

Back 13

Doxorubicin (adriamycin)

Front 14

Cardiotoxic drug that can cause a cardiomyopathy resulting in heart failure?

Back 14

Doxorubicin

Front 15

This drug is nephrotoxic, hepatotoxic, toxic to skin, and has the ability to cause fibrosis of the lung?

Back 15

Bleomycin

Front 16

List the 4 Fluoroquinolones

Back 16

ciprofloxacin, levofloxacin, moxifloxacin, and gemifloxacin

Front 17

MOA of fluoroquinolones

Back 17

inhbit bacterial DNA gyrase

Front 18

These antibiotics are not approved in children <16 yo d/t risk of joint cartilage and caution must be taken in those >60 yo d/t increased risk for tendinopathy?

Back 18

Fluoroquinolones

Front 19

Fluoroquinolones have excellent action against Gram negative or Gram positive bacteria?

Back 19

BOTH