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19 Cards in this Set
- Front
- Back
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Three lines of defense |
1. Skin and mucous 2. Inflammation response 3. Immune response what i |
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What is acute inflammation triggered by? |
Any sort of tissue injury |
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White blood cells release what? |
Cytokines |
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Mast cells: |
Granules filled with inflammatory markers which are "on guard" near blood vessles |
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Basophils: |
Function like mast cells i blood |
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Platelets: |
Contains inflammatory mediators |
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Damaged cells: |
Release fatty acids |
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Inflammation response begins with: |
A flood of inflammatory chemicals released into the extra cellular fluid |
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Inflammation mediators |
Includes kinins, prostaglandins, complement and cytokines Are released by tissue injury, phagocytes, lymphocytes and mast cells Cause local small blood vessels to dilate resulting in hyperaemia. |
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Vascular permeability |
Chemicals liberated by the inflammatory response increases the permeability of local capillaries. |
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Example of vascular permeability |
Exudate: fluid containing proteins, clotting factors and antibodies seeping into tissue spaces causing oedema, which contributes to the sensation of pain. |
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Cellular response is regulated by what? |
Inflammatory mediators |
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Chemotaxis: |
Inflammatory mediators attract WBC to the area |
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Adherence: |
WBCs also platelets and RBCs cling to the capillaries in affect area. |
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Migration (diapedesis): |
WBCs, RBCs and platelets squeeze between endothelial cells |
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Phagocytosis/chemotaxis |
WBCs begin phagocytosis and release chemotactic factors to attract more WBCs |
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Local manifestations: |
Includes heat, incapacitation, pain, swelling and redness |
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System manifestations: |
May include fever, fatigue, weight loss, lethargy, headache, increased circulating leukocytes and plasma proteins |
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Well done |
You did it |
