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52 Cards in this Set

  • Front
  • Back

heat

calor

redness

rubor

swelling

tumor

pain

dolor

loss of fxn

functio laesa

protective response involving host cells, blood vessels, and proteins and other mediators that is intended to eliminate the initial cause of cell injury

Inflammation

a body defense reaction in order to eliminate or limit the spread of injurious agent, followed by removal of the necrosed cells and tissues.

Inflammation

immunologists refer to as innate immunity

Inflammation

TRUE OR FALSE


the inflammatory reaction and the subsequent repair process can themselves cause considerable harm.

TRUE

“Known as the external signs of inflammation”

Cardinal Signs of Inflammation

The first four of these CARDINAL SIGNS were described more than 2000 years ago by a Roman encyclopedist named

Celsus

father of modern pathology

Rudolf Virchow

vasodilation mediated by prostaglandins (PGE, prostacyclin) causing hyperemia

Redness (Rubor)

increased vascular permeability mediated by vasoactive amines (histamine, serotonin) C3a, C5a, bradykinin, leu

Swelling (Tumor)

warmth due to increased blood flow (hyperemia)

Heat (Calor)

increased pressure exerted by edema and stimulation of pain-sensitive nerve endings by prostaglandin & bradykinin

Pain (Dolor)

pain on pressure is tenderness

Pain (Dolor)

due to pain and immobility

Loss of Function (Functio Laesa)

Rapid in onset and of short duration, lasting from a few minutes to hours to as long as a few days (generally < 2 weeks).

Acute Inflammation

common and medically important causes of inflammation.

TRAUMA


TISSUES NECROSIS


FPREIGN BODIES\


IMMUNE REACTIONS

Changes in vascular caliber and flow (Increased blood flow secondary to vasodilation) Increased vascular permeability

VASCULAR CHANGES

Leukocyte recruitmentLeukocyte activation

CELLULAR EVENTS

The principal leukocytes in acute inflammation are --

neutrophils (polymorphonuclear leukocytes)

Changes in Vascular Caliber and Flow

. Transient vasoconstriction


. Arteriolar vasodilation

Escape of fluid, proteins and blood cells from the vascular system into the interstitial tissue or body cavities

EXUDATION

Inflammatory extra-vascular fluid with high protein concentration and cellular debris and high specific gravity


typical of inflammation

Exudate

Fluid with decreased protein concentration (low protein content), little or no cellular material and low specific gravity


accumulate in various non-inflammatory conditions

Transudate

outpouring of a watery, relatively protein-poor fluid

Serous inflammation

fluid in a serous cavity is called an

effusion.

Skin blister resulting from a burn or viral infection either within or immediately beneath the epidermis of the skin

Serous inflammation

Pleural effusion in tuberculosis

Serous inflammation

More of plasma proteins (fibrinogen) and fibrin (thread-like or solid amorphous eosinophilic coagulum)

Fibrinous inflammation

Characteristic of inflammation in the lining of body cavities: meninges, pericardium, pleura

Fibrinous inflammation

characteristic of inflammation in the lining of body cavities, such as the meninges, pericardium, and pleura.

fibrinous exudate

ingrowth of fibroblasts and blood vessels

organization

Manifested by the collection of large amounts of purulent exudate (pus) consisting of neutrophils, necrotic (liquefactive) cells, and edema fluid.

Suppurative (purulent) inflammation

pus-forming

pyogenic

Acute appendicitis

Suppurative (purulent) inflammation

are focal collections of pus that may be caused by seeding of pyogenic organisms into a tissue or by secondary infections of necrotic foci.

Abscesses

the usual outcome with abscess formation

scarring

ABSCESS IN THE LUNG

Suppurative (purulent) inflammation

an inflammatory process that occurs in mucous membranes

Catarrhal inflammation

common cold (nasopharyngitis, rhinopharyngitis) rhinitis

Catarrhal inflammation

Refers to a local defect, or excavation, of the surface of an organ or tissue that is produced by necrosis of cells and sloughing (shedding) of necrotic and inflammatory tissue

Ulcer

peptic ulcer of the stomach or duodenum

ULCER

It is inflammatory response of mucous surface (oral, respiratory, bowel) to toxins of diphtheria or irritant gases.

Pseudomembranous inflammation

false membrane

Pseudomembranous inflammation

Diphtheria, membranous enterocolitis

Pseudomembranous inflammation

It is a diffuse inflammation of soft tissues resulting from spreading effects of substances like hyaluronidase released by some bacteria.

Cellulitis

defined as presence of small number of bacteria in the blood which do not multiply significantly. They are commonly not detected by direct microscopy.

Bacteremia

means presence of rapidly multiplying, highly pathogenic bacteria in the blood e.g. pyogenic cocci

Septicemia

is the dissemination of small septic thrombi in the blood which cause their effects at the site where they are lodged.

Pyemia