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33 Cards in this Set
- Front
- Back
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What are the vascular events? |
Vasodilation, permeability, homoconcentration, Stasis |
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What are the cellular events> |
Adhesion, Migration, Chemotaxis, Phagocytosis |
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Describe the cast of characters? |
Poly- Neutrophil, messy eater, colorful Monty-Monocyte, aggressive Pacman- MAcrophage, eats everything feisty) Rush- Lympohocyte (cranky, opinoonated) Rushes into an inflammatory situation |
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Order of inflammation events |
vasoconstriction, Vasodilation, stasis |
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Vasodilation leads to what |
leaky vessels |
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4 permeability mechanisms |
Transcytosis, Nuetrophil adhesion, Vessel injury and Endothelial gap formation |
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What is transcytosis? Mediated by what? |
When vesicles transport fluid into the vascular stream through endothelium. Mediated by VEGF |
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What is in the serum? |
Protein cells water, |
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What role does ccvascular pressure play in inflammation |
none |
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Why don't we have edema forever |
The fluid drains into the lymph |
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what results from fluid loss? |
hemoconcentration which moves WBC's to the surface |
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Whats a transudate and whats an exudate |
Trans-mostly H20 Early acute inflammation Exudate-H20 Protein and cells |
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Which cellular even doesn't use adhesionmolecules |
margination |
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Order on inflammation cellular events |
MArgination, tethering, rolling, firm adhesion, transmigration, chemotaxis and aggregation, phagocytosis |
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What is t5ansmigration |
This is when WBC's cross the endothelium |
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What is margination? |
This is when WBC's for a layer on the endothelium in post capillary Venule |
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what os chemotaxis |
This is the attraction of a WBC to the site of a n injury |
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What do Selectins have? |
Selectins have lectin domain which binds to Lewis X (addressin) A carbohydrate |
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What do addressins have? |
They have a sialyl Lewis X( Carbohydrate) |
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What are the four adhesion molecules in inflammation? |
Addressins, Selectins, Integrins and Imunoglobulins |
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Where does integrin bind? |
This binds to the endothelium where ICAMs sit. |
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P selectin binds to what? Involved in what |
Sialyl Lewis X (ALL WBC's) Tethering |
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ELAM Binds to what? Involved in what |
Binds to Sialyl Lewis X (Polys and Monos)and is involved in rolling
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ICAM binds to what and is involved in what? |
Binds to CD 18 (ALLWBC's) Involved in Adhesion |
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Example of an integral, example of an addressin |
24-ICAM 48-CD34 |
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What draws the WBC's to the actual wound? |
Chemotaxis. Mediators help this |
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What type of cells are in the wound after the first 24 hours? 48? |
24- Polys 48- Monocytes/ Macrophages |
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What is C5a |
Chemotaxis agent 5 |
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how does cells move? |
filipidium |
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How does phagocytosis occur? |
Phagosome fuses with a lysosome |
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Features of mediators? |
The are redundant with a short half life and the amplify the reaction. Cellular or plasma |
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3 types of plasma mediators |
Kinins, complements and coag factors |
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2 types of cellular mediators |
Preformed elements, synthesized elements |
