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15 Cards in this Set
- Front
- Back
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Apoptosis
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- ATP Required
- extrinsic or intrinsic - activation of "cytosolic caspases" |
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Intrinsic Apoptosis
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- tissue remodling in embryogenesis
- growth factor is withdrawn from cell - ex: IL2 dec after an immune reaction - post exposure to injurious stimuli - radiation, toxin, hypoxia - increased mitochondria permeability and cytochrome c release - Bax - pro apoptotic - Bcl2 - anti apoptotic |
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Extrinsic Apoptosis
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2 pathways
- ligand receptor interactions (Fas ligand binding to Fas [CD95] - immune cell (cytotoxic T cell release of perforin and granzyme B) |
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Necrosis
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exogenous injury leads to enzymatic degradation
intracellular components extravasate inflammatory (unlike apoptosis) |
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Heart necrosis
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coagulative
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Liver necrosis
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coagulative
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Kidney necrosis
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coagulative
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brain necrosis
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liquefactive
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bacterial abscess
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liquefactive
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pleural effusion abscess
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liquefactive
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TB necrosis
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caseous
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systemic fungi necrosis
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caseous
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peripancreatic fat necrosis
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fatty
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blood vessel
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fibrinoid
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gangrenous necrosis
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dry - ischemic coagulative
wet - with bacteria common in limbs and in GI |
