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20 Cards in this Set
- Front
- Back
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Cardinal Signs
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Rubor: dilate vessels
Dolor: bc press & Bradykinin Calor: bc Inc bld flow Tumor: bc Extravasc accum Functio laesa |
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Selectins
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L-selectins: on Neutrophils
E/P selectins: on endothel |
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Neutrophils
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Acute Inflam (1st 24 hr)
Bact Infec/Infarct Band Neutrophils |
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Monocyte-Macrophage
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TB, Brucellosis, Typhus, Salmonella
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Lyphocytes
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vs. Viral infec
& Chronic Inflam |
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Emigration
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Leukos btwn endothel cells
Margination Pavementing Rolling- selectins loose Adhesion- integrins Transmigration- PECAM-1 |
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Chemotactic Factors for Neutrophils
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Bact Products
C5a LT-B4, HETE, Kallikrein |
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Phagocytes
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Neutrophils
Monocytes-Macrophages |
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Opsonins
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IgG and C3b
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Histamine
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Inc Cap Perm
from Basophil, Mast cell, Platelet DeGran bc IgE (no C') or Anaphylatoxins (C3a, C5a) or Heat/Cold or IL-1 |
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VasoActive Mediators
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Vasoconstrict: TXA2
Vasodilate: PGI2 Inc Vasc Perm: Histamine and NO |
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Factor XIIa
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Links the Kinin, Coag, Plasminogen, and C' Systems
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Chronic Inflam
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Replace Neutrophils/Monocytes
with Lyphocytes, Plasma Cells, & Macrophages |
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Chronic Granulomatous Dz of Childhd
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(X-linked)
Defic Act of NADPH Oxidase Ingest but dont kill Esp Catalae Pos (StaphAureus) |
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Chediak-Higashi Syndrome
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(Auto-Reces)
Neutropenia, Albinism, Neuropathy Bc Abnorm Microtubule form Lg Cyto Granules |
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Granulomatous Inflam
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Macrophages= Epitheloid Cells
Rim of Lymphocytes Multinucleated Giant Cells Inc: Langerhans/FB Giant cell |
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Transforming Grwth Factors
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TGF-a: like EGF
TGF-B: grwth inhibitor (repair) |
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Macrophage derived grwth factor
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IL-1, THF
Prolif fibroblasts, smth musc, endothel cells |
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Granulation Tissue
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Highly vascular, newly formed CT, Cap/Fibroblasts
Fills defect from Liq necrosis NOT related to Granulmatous Inflam |
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Scarring
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Collagen (from Fibroblast)
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