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20 Cards in this Set

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Cardinal Signs
Rubor: dilate vessels
Dolor: bc press & Bradykinin
Calor: bc Inc bld flow
Tumor: bc Extravasc accum
Functio laesa
Selectins
L-selectins: on Neutrophils
E/P selectins: on endothel
Neutrophils
Acute Inflam (1st 24 hr)
Bact Infec/Infarct
Band Neutrophils
Monocyte-Macrophage
TB, Brucellosis, Typhus, Salmonella
Lyphocytes
vs. Viral infec
& Chronic Inflam
Emigration
Leukos btwn endothel cells
Margination
Pavementing
Rolling- selectins loose
Adhesion- integrins
Transmigration- PECAM-1
Chemotactic Factors for Neutrophils
Bact Products
C5a
LT-B4, HETE, Kallikrein
Phagocytes
Neutrophils
Monocytes-Macrophages
Opsonins
IgG and C3b
Histamine
Inc Cap Perm
from Basophil, Mast cell, Platelet
DeGran bc IgE (no C')
or Anaphylatoxins (C3a, C5a)
or Heat/Cold or IL-1
VasoActive Mediators
Vasoconstrict: TXA2
Vasodilate: PGI2
Inc Vasc Perm: Histamine
and NO
Factor XIIa
Links the Kinin, Coag, Plasminogen, and C' Systems
Chronic Inflam
Replace Neutrophils/Monocytes
with Lyphocytes, Plasma Cells, & Macrophages
Chronic Granulomatous Dz of Childhd
(X-linked)
Defic Act of NADPH Oxidase
Ingest but dont kill
Esp Catalae Pos (StaphAureus)
Chediak-Higashi Syndrome
(Auto-Reces)
Neutropenia, Albinism, Neuropathy
Bc Abnorm Microtubule form
Lg Cyto Granules
Granulomatous Inflam
Macrophages= Epitheloid Cells
Rim of Lymphocytes
Multinucleated Giant Cells
Inc: Langerhans/FB Giant cell
Transforming Grwth Factors
TGF-a: like EGF
TGF-B: grwth inhibitor (repair)
Macrophage derived grwth factor
IL-1, THF
Prolif fibroblasts, smth musc, endothel cells
Granulation Tissue
Highly vascular, newly formed CT, Cap/Fibroblasts
Fills defect from Liq necrosis
NOT related to Granulmatous Inflam
Scarring
Collagen (from Fibroblast)