Anaphylactic disorder is one of the end result of immediate (Type I) hypersensitivity reaction. It starts when antigen (bee sting as in the patient’s case) binds to IgE antibody on the surface of mast cells that result of systemic release of vasoactive amines and other mediators from mast cells. The presence of IgE antibody indicate that this is not the first exposure to this antigen. The mast cells have a specific receptor for the Fc portion of IgE called FceRI (a high-affinity receptor). When IgE binds to mast cells the cell became sensitized and activated. However, these mediators such as histamine, tryptase, heparin, chymase, and cytokines are stored in the granules of mast cells. Histamine is thought to be the primary mediator of anaphylactic
