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15 Cards in this Set
- Front
- Back
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Acute inflammation |
Local reaction Movement of protein and cells from blood to tissue Predominantly neutrophils |
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What enzymes kills neutrophils |
Myeloperoxidase |
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C3a |
Adhesion molecules on blood vessel walls Sticky so causes neutrophils to slow down Eventually lots of adhesion molecule near infection eventually stops |
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Neutrophils in responses to adhesion molecules |
Neutrophils can move out of blood due to increased vascular permeability follow cytokines |
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C3a and c5a |
Activate mast cell |
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Mast cell function |
Resident in tissue Release of vasoactive amines Release of cytokines |
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Inflammatory |
Cytokines Chemokines Complement Amines |
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Chronic granulomasdisease |
Mutations in genes for NADPH oxidase No respiratory burst No ph change in phagosome No damage to pathogens Infections are not cleared |
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Inflammatory cytokines stimulate production of acute phase protein |
Stimulate production of CRP and MBP |
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CRP binds to |
Bacterial and fungal cell walls |
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C4 binds to mbl |
C4 gets cleaved C4b attaches to cell and binds 2a Together this can cleave C3 |
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CRP |
Makes c3 convertase |
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Infected cells produce IFN-a and IFN -B this produces the response of |
Induce resistance to viral replication Increase expression of ligands for receptors on NK cells Activate cells to kill virus infected cells |
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NK cells |
Large granular lymphocytes Activity increases 20-100 times on exposure to the interferons NK provide an early response to virus infection until cytokines cells |
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How is NK killing controlled |
Normal cells have receptors that inhibit NK that damages cells don’t have Infected cells have nkg2d ligands that bind to receptor on NK |
