Immunostains - Bumc Path

Front 1

Used to identify endothelial differentiation or angiosarcoma; most specific endothelial marker

Normally stains endothelial cells and megakaryocytes (cytoplasmic and membranous), also macrophages

Back 1

CD31

Front 2

Used to identify vascular sarcomas, Kaposi's sarcoma, gastrointestinal stromal tumor (GIST), solitary fibrous tumor, dermatofibrosarcoma protuberans (DFSP), epithelioid sarcoma, plus some other soft tissue tumors. Synovial sarcoma is negative

Normally stains endothelial cells, fibroblasts, and hematopoietic blasts (cytoplasmic and membranous)

Back 2

CD34

Front 3

Used to identify endothelial differentiation, specific but not very sensitive

Normally stains endothelial cells, megakaryocytes, platelets (cytoplasmic)

Back 3

FVIII

Front 4

Used to identify meningioma, perineuroma, chordoma, mesothelioma, sebaceous carcinoma, plus some sarcomas (synovial sarcoma, epithelioid sarcoma) and plasma cell neoplasms. Germ cell tumors (excluding some teratomas) are negative

Entities that are positive for this stain and keratin negative: meningioma, perineuroma, plasma cell myeloma

Normally stains epithelial, perineural, meningothelial cells (cytoplasmic or membranous)

Back 4

EMA

Front 5

Used to identify astrocytoma, glioblastoma multiforme (GBM), and ependymoma; also myoepithelial tumors of salivary gland. Oligodendroglioma and neuroblastoma are negative

Normally stains glial cells (cytoplasmic)

Back 5

GFAP

Front 6

Used to identify neural differentiation but not very specific (not the same as nonspecific esterase, an enzyme assay for heme path). Sensitive for neuroblastoma

Normally stains neuroectodermal and neuroendocrine cells (cytoplasmic)

Back 6

NSE (neuronal-specific enolase)

Front 7

Used to identify cellular schwannoma, astrocytomas/GBM, granular cell tumor, chordoma, ependymoma, malignant peripheral nerve sheath tumor (MPNST), and melanocytic lesions (all types). Breast cancer may also be positive

Normally stains glial cells, Schwann cells, dendritic and Langerhans cells, melanocytes, other mesenchymal cells (nuclear and cytoplasmic)

Back 7

S100

Front 8

Used to identify carcinoids, paraganglioma, pheochromocytomas, small cell, medullary carcinoma of thyroid, neuroblastoma, islet cell tumors, others. Differentiates neural differentiation (positive) from glial (negative)

Normally stains neuroendocrine cells (cytoplasmic)

Back 8

Synaptophysin

Front 9

Used to identify ductal breast lesions; loss of staining identifies lobular carcinoma (in situ and invasive)

Normally stains ductal and lobular cells (membranous)

Back 9

E-cadherin

Front 10

Used to identify metastatic breast cancer, some gynecologic tumors, and others; also for breast cancer prognosis (predicts response to tamoxifen)

Normally stains estrogen receptor (nuclear) and
progesterone receptor (nuclear)

Back 10

ER and PR

Front 11

Used to identify breast carcinoma, also sweat and salivary gland carcinoma

Normally stains apocrine metaplasia of breast and apocrine sweat glands (cytoplasmic)

Back 11

GCDFP

Front 12

Used to evaluate breast carcinomas (overexpression is a poor prognostic sign but can be treated with Herceptin)

Normally stains growth factor receptor that is only weakly expressed in normal epithelial cells (membranous and cytoplasmic)

Back 12

Her2Neu

Front 13

Used to gauge mitotic activity for prognosis

Normally stains any proliferating cell (nuclear)

Back 13

Ki67 (MIB-1)

Front 14

Used to identify the myoepithelial layer of breast and rule out invasive cancer

Normally stains smooth muscle: myoepithelial cells, blood vessels, myofibroblasts (cytoplasmic)

Back 14

α-Actin

Front 15

Used to identify myoepithelial cells but not endothelium and fi broblasts—cleaner stain than actin/SMMHC; also stains metaplastic carcinoma

Normally stains a tumor supressor gene (nuclear)

Back 15

p63

Front 16

Used to identify the myoepithelial layer of breast and rule out invasive cancer

Normally stains myoepithelial cells, blood vessels, myofibroblasts (cytoplasmic)

Back 16

SMMHC (smooth muscle myosin-heavy chain)

Front 17

Used to differentiate usual ductal hyperplasia (positive) from ductal carcinoma in situ (negative) of breast; also stains metaplastic carcinoma

Normally stains myoepithelial cells (cytoplasmic and membranous) and usual duct hyperplasia

Back 17

CK903

Front 18

Used to identify carcinomas in general; used in conjunction with Cam 5.2 to screen for carcinoma

Normally stains most epithelial cells (cytoplasmic), except cytokeratins 8 and 18

Back 18

AE1-AE3

Front 19

Used in conjunction with AE1/AE3 to screen for carcinoma; also to identify hepatocellular carcinoma, some adrenal cortical tumors, and some carcinomas that are negative for other keratins (undifferentiated carcinoma)

Normally stains low- and intermediate-molecular weight keratins 8, 18, and 19 (cytoplasmic)

Back 19

Cam 5.2

Front 20

Used to differentiate squamous cell carcinoma (positive) or mesothelioma (positive) from adenocarcinoma (negative)

Normally stains two specific high-molecular-weight keratins (cytoplasmic)

Back 20

CK5/6

Front 21

Used to identify above-the-diaphragm carcinomas; used in combination with CK20 to narrow the differential of carcinoma of unknown origin

Normally stains a specific low-molecular-weight cytokeratin (cytoplasmic)

Back 21

CK7

Front 22

Used to identify below-the-diaphragm carcinomas and in Merkel cell carcinoma; used in combination with CK7 to narrow the differential of carcinoma of unknown origin

Normally stains a specific low-molecular-weight cytokeratin (cytoplasmic)

Back 22

CK20

Front 23

Used to identify prostatic basal cells (loss of staining indicates carcinoma), and transitional cell (urothelial) carcinoma (positive); also metaplastic breast carcinoma

Normally stains high-molecular-weight keratin (cytoplasmic and membranous)

Back 23

CK903 (34ßE12)

Front 24

CK7/20 - positive or negative?

Urothelial carcinoma, pancreatic carcinoma, ovarian mucinous carcinoma

Back 24

CK7+ / CK20+

Front 25

CK7/20 - positive or negative?

Breast carcinoma, non-small cell lung carcinoma, ovarian serous carcinoma, endometrial carcinoma, epithelial mesothelioma, thymoma

Back 25

CK7+ / CK20-

Front 26

CK7/20 - positive or negative?

Colorectal carcinoma, Merkel cell carcinoma

Back 26

CK7- / CK20+

Front 27

CK7/20 - positive or negative?

Hepatocellular carcinoma, clear cell renal cell carcinoma, prostate carcinoma, neuroendocrine small cell carcinoma, squamous cell carcinoma

Back 27

CK7- / CK20-

Front 28

Used to identify yolk sac tumor and hepatocellular carcinoma; may also stain other carcinomas

Normally stains fetal tissues (cytoplasmic)

Back 28

AFP

Front 29

Used to identify seminoma (membranous) and mature teratoma, plus GIST in stomach

Normally stains germ cells, mast cells, interstitial cells of Cajal (cytoplasmic or membranous)

Back 29

c-kit

Front 30

Used to identify seminoma, yolk sac tumor, and embryonal carcinoma; should be negative in all of them

Normally stains epithelial, perineural, meningothelial cells (membranous)

Back 30

EMA

Front 31

Used to identify choriocarcinoma and germ cell tumors, some adenocarcinoma

Normally stains human chorionic gonadotropin β-chain (cytoplasmic) in syncytiotrophoblasts

Back 31

β-hCG

Front 32

Used to identify germ cell tumors, moles, and choriocarcinoma, also some carcinomas

Normally stains trophoblasts (cytoplasmic)

Back 32

HPL

Front 33

Used to identify embryonal carcinoma, Hodgkin’s lymphoma, and anaplastic large cell lymphoma (ALCL)

Normally stains activated lymphocytes

Back 33

Ki-1 (CD30)

Front 34

Used to identify germ cell tumors, intratubular germ cell neoplasia, others; does not stain spermatocytic seminoma

Normally stains placenta (cytoplasmic)

Back 34

PLAP

Front 35

Used to identify nonmucinous ovarian carcinoma (usually negative)

Normally stains mesothelial cells and in the luminal surface of epithelial cells of the fallopian tube, endometrium and endocervix

Back 35

CA-125

Front 36

Used to identify choriocarcinoma and germ cell tumors

Normally stains human chorionic gonadotropin β-chain (cytoplasmic) in syncytiotrophoblasts

Back 36

β-hCG

Front 37

Used to identify germ cell tumors, moles, choriocarcinoma, and some carcinomas

Normally stains trophoblasts (cytoplasmic)

Back 37

HPL

Front 38

Used to identify sex cord stromal tumors (granulosa cell, Sertoli and Leydig) and moles, choriocarcinomas, fibrothecomas, and adrenal cortical tumors

Normally stains granulosa cells, Sertoli cells, others (cytoplasmic)

Back 38

Inhibin

Front 39

Used to identify placental site trophoblastic tumor (PSTT), choriocarcinoma

Normally stains intermediate trophoblasts

Back 39

Melcam (CD146)

Front 40

Used to identify serous ovarian carcinoma, mesothelioma, and pancreatic carcinoma (also a target for immunotherapy)

Normally stains mesothelial cells (membranous)

Back 40

Mesothelin

Front 41

Used to identify high-grade squamous intraepithelial lesion (HSIL) and HPV lesions of cervix and to differentiate between endocervical (positive) and endometrial (negative) adenocarcinoma

Normally stains cells infected by HPV (nuclear)

Back 41

p16

Front 42

Used to identify endometrial intraepithelial carcinoma (EIC) and serous carcinoma of endometrium

Normally stains a tumor suppressor gene variant that should be absent in normal cells (nuclear)

Back 42

p53

Front 43

Used to identify a subset of anaplastic large cell lymphoma (ALCL) and diffuse large B-cell lymphoma (DLBCL); Hodgkin's lymphoma is negative

Normally stains a fusion protein expressed by only lympomatous cells

Back 43

ALK

Front 44

Used to differentiate follicular lympoma (positive) from reactive follicles (negative); also stains mantle cell lympoma; Burkitt's lymphoma should be negative

Normally inhibits apoptosis and turns off in a germinal center (membranous and cytoplasmic stain)

Back 44

bcl-2

Front 45

Used to identify lymphomas of follicular origin ( follicular center cell lymphoma (FCC), Burkitt’s lymphoma)

Normally stains germinal center cells (cytoplasmic)

Back 45

bcl-6

Front 46

Used to identify Langerhans cell proliferations, T-LBL (lymphoblastic lymphoma)

Normally stains thymocytes (immature T cells) and Langerhans cells (membranous)

Back 46

CD1a

Front 47

Used to identify T-cell lymphomas and leukemias; ___ is also dimly positive in monocytic/histiocytic lesions

Normally stains T cells

Back 47

CDs 3, 4, 5, 7, 8
___= CD4

Front 48

Used to identify follicular center cell (FCC), ALL, lymphoblastic lymphoma (LBL), Burkitt’s lymphoma, and CML; MALTomas are negative

Normally stains precursor B and T cells, granulocytes (membranous)

Back 48

CD10

Front 49

Used to identify B-cells; stains B-cells lymphomas, but plasmacytomas are negative

Normally stains B cells (cytoplasmic and membranous)

Back 49

CD20

Front 50

Used to identify Reed-Sternberg cells (classic Hodgkin's), some large T-cell lymphomas and mycosis fungoides

Normally stains granulocytes and macrophages (membranous and dot-like perinuclear)

Back 50

CD15 (LeuM1)

Front 51

Used to identify SLL/CLL; mantle cell lymphomas are negative

Normally stains B cells, IgE receptor (membranous)

Back 51

CD23

Front 52

Used to identify Reed-Sternberg cells, anaplastic large cell lymphoma (ALCL), large B- and T-cell lymphomas

Normally stains activated B and T cells, immunoblasts, other nonheme cell types (cytoplasmic, membranous)

Back 52

CD30

Front 53

Used to identify blasts in the marrow in acute leukemias; also many soft tissue tumors

Normally stains hematolymphoid blasts, fibroblasts, and endothelial cells (cytoplasmic and membranous)

Back 53

CD34

Front 54

Used to identify poorly differentiated neoplasms as of hematopoietic origin

Normally stains lymphocytes, granulocytes, and histiocytes, but not plasma cells (cytoplasmic, membranous)

Back 54

CD45 (CLA/LCA)

Front 55

Used to identify natural killer/T-cell lymphomas

Normally stains natural killer cells (membranous)

Back 55

CD56

Front 56

Used to identify histiocytic origin; also stains soft tissue tumors

Normally stains histiocytes/macrophages/monocytes, granulocytes, others (cytoplasmic, membranous)

Back 56

CD68

Front 57

Used to identify B-cell neoplasms negative for other B-cell markers; stains B-ALL and B lymphomas, myelomas

Normally stains B cells and plasma cells (membranous)

Back 57

CD79a

Front 58

Used to identify plasma cell neoplasms

Normally stains plasma cells (membranous), epithelial cells

Back 58

CD138

Front 59

Used to identify mantle cell lymphoma

Normally stains nucleus in mantle cell lymphoma

Back 59

cyclin D1

Front 60

Used to identify nasopharyngeal carcinoma, posttransplantation/AIDS lymphomas; also mononucleosis; these are EBV-related tumors

Normally stains EBV RNA in infected B cells (nuclear)

Back 60

EBV EBER

Front 61

Used to identify megakaryocytic leukemias

Normally stains megakaryocytes, platelets, and endothelial cells, (cytoplasmic)

Back 61

FVIII (vWF)

Front 62

Used to identify erythroid leukemias (rare)

Normally stains hemoglobin in erythroid cells (cytoplasmic)

Back 62

hemoglobin

Front 63

Used to identify a monoclonal population of B or plasma cells, when it is restricted to this type of staining

Normally stains light chain of immunoglobulins in plasma cells and B cells (cytoplasmic)

Back 63

Kappa and lambda

Front 64

Used to gauge mitotic activity and identify Burkitt’s lymphoma (100% positivity)

Normally stains any proliferating cell (nuclear)

Back 64

Ki67 (MIB-1)

Front 65

Used to identify AML and myeloid sarcoma (chloroma)

Normally stains enzyme granules in myeloid-lineage cells (cytoplasmic)

Back 65

MPO

Front 66

Used to identify large B-cell lymphoma (LBL) and ALL

Normally stains immature lymphocytes (nuclear)

Back 66

TdT

Front 67

Used to identify renal cell carcinoma

Normally stains proximal renal tubules (cytoplasmic)

Back 67

RCC (gp200/RTA)

Front 68

Used to identify Xp11-translocation RCC and alveolar soft part sarcoma

Normally stains a transcription factor (nuclear)

Back 68

TFE3

Front 69

Used to identify t(6:11) renal cell carcinoma

Normally stains a transcription factor (nuclear)

Back 69

TFE3B

Front 70

Used to identify TCC, mesothelioma, some vascular tumors

Normally stains both endothelial (cytoplasmic) and mesothelial (membranous) cells

Back 70

Thrombomodulin

Front 71

Used to identify Wilms’ tumor; also mesothelioma, desmoplastic small round cell tumor

Normally stains a tumor suppressor gene in developing nephrons; nephrogenic rests and adult glomerular podocytes (nuclear)

Back 71

WT-1

Front 72

Used to highlight globules of α1-antitrypsin disease; not specific to a tumor

Normally stains histiocytes and reticulum cells (cytoplasmic)

Back 72

α1-antitrypsin

Front 73

Used to identify HCC and yolk sac tumors; may also stain other carcinomas

Normally stains fetal tissues (granular cytoplasmic)

Back 73

AFP

Front 74

Used to identify colon cancer, abdominal fibromatosis, and solid pseudopapillary tumor of pancreas (positive)

Normally stains APC-binding protein present in most cells (only nuclear staining is significant; indicates a mutation in APC or β-catenin)

Back 74

β-Catenin

Front 75

Used to identify a canalicular pattern in HCC

Normally stains liver canaliculi, brush border of small bowel, other tissues

Back 75

CD10

Front 76

Used to identify a canalicular pattern in HCC (not seen with mCEA); also stains lung, colon, pancreatic carcinoma

Normally stains fetal tissues and adenocarcinomas (cytoplasmic)

Back 76

pCEA

Front 77

Used to identify pancreatic carcinoma (55% of in situ or invasive cancers exhibit loss of staining)

Normally stains most normal tissues (cytoplasmic)

Back 77

DPC-4 (clone B8)

Front 78

Used to predict response to Erbitux (a monoclonal antibody) in advanced colon cancer

Normally stains hepatocytes, perineurium in peripheral nerves, squamous epithelium

Back 78

EGFR

Front 79

Used to identify HCC (mod to poorly diff = loss)

Normally stains mitochondria in normal hepatocytes (granular cytoplasmic stain)

Back 79

HepPar1 (OCH1E5)

Front 80

Used to differentiate mesothelioma (negative) from carcinoma (positive)

Normally stains epithelial cells (membranous)

Back 80

BerEP4

Front 81

Used to differentiate mesothelioma (negative) from adenocarcinoma (positive)

Normally stains fetal tissues and mucin-secreting glandular tissues (cytoplasmic)

Back 81

mCEA and pCEA

Front 82

Used to differentiate epithelial mesothelioma (positive) from carcinoma (negative)

Normally stains various neural and epithelial cells (cytoplasmic and nuclear)

Back 82

Calretinin

Front 83

Used to differentiate mesothelioma (negative) from adenocarcinoma (positive)

Normally stains hematopoietic cells and some carcinomas (membranous and cytoplasmic)

Back 83

LeuM1 (CD15)

Front 84

Used to differentiate nonsquamous carcinoma of lung origin (including adenocarcinoma, small cell, and neuroendocrine/all positive) from nonpulmonary (negative)

Normally stains a transcription factor in lung and thyroid (nuclear)

Back 84

TTF-1

Front 85

Used to differentiate epithelial mesothelioma (positive) from carcinomas (negative)

Normally stains mesothelium (nuclear)

Back 85

WT-1

Front 86

Used to identify epithelioid melanoma, metastatic melanoma, angiomyolipoma, clear cell sarcoma, perivascular epithelioid cell tumors, and others; less sensitive than other markers for melanoma

Normally stains immature melanocytes (cytoplasmic)

Back 86

HMB45

Front 87

Used to identify melanoma (mainly epithelioid)

Normally stains melanocytes (cytoplasmic)

Back 87

MART-1/Melan-A (N2-7C10 clone)

Front 88

Used to identify melanoma (mainly epithelioid) and angiomyolipoma; labels steroid cell tumors (adrenocortical tumors, Sertoli and Leydig cell tumors)

Back 88

Melan-A (A103 clone)

Front 89

Used to identify melanoma and melanocytic tumors, also angiomyolipoma

Normally stains melanocytes (nuclear)

Back 89

MitF

Front 90

Used to identify nevi and melanoma (all types, most sensitive), cellular schwannoma, granular cell tumor, glial neoplasms; not used to screen lymph nodes, as normal dendritic cells are positive

Normally stains melanocytes, glial cells, dendritic
and Langerhans cells, other mesenchymal cells (nuclear and cytoplasmic)

Back 90

S100 protein

Front 91

Used to differentiate pheochromocytoma (positive) from adrenal cortical carcinoma (negative) or to identify carcinoids, small cell, Merkel cell, and islet cell tumors

Normally stains neurosecretory granules (cytoplasmic,
granular) in endocrine tissues and neurons

Back 91

Chromogranin

Front 92

Used to identify adrenal cortical tumors, stromal sex cord tumors (granulosa cell, Sertoli and Leydig), fibrothecomas

Normally stains adrenal cortical cells (cytoplasmic)

Back 92

Inhibin

Front 93

Used to identify carcinoids, paragangliomas, pheochromocytomas, small cell carcinoma, medullary
carcinoma of thyroid, neuroblastoma, islet cell tumors, others

Normally stains neuroendocrine cells (cytoplasmic),
neuromuscular junction, Merkel cells

Back 93

Synaptophysin

Front 94

Used to identify products of neuroendocrine tumors, such as islet cell tumors and others

Normally stains cells that these respective hormones (cytoplasmic)

Back 94

insulin, somatostatin, gastrin, glucagon, parathyroid hormone, etc.

Front 95

Used to identify prostatic basal cells (loss of staining indicates carcinoma) and TCC (positive)

Normally stains high-molecular-weight keratin (cytoplasmic and membranous) in basal cells

Back 95

CK903 (34ßE12)

Front 96

Used to identify prostate basal cells (loss of staining indicates carcinoma)

Normally stains prostatic gland basal cells (nuclear)

Back 96

p63

Front 97

Used to identify metastatic or ambiguous prostate cancer; seminal vesicle is negative

Normally stains prostatic epithelium (cytoplasmic), but also salivary gland

Back 97

PSA

Front 98

Used to identify metastatic or ambiguous prostate cancer and transitional cell carcinoma; also stains rectal carcinoids

Normally stains prostatic epithelium (cytoplasmic)

Back 98

PSAP (PAP)

Front 99

Used to confirm prostate carcinoma; also stains nephrogenic adenoma of bladder

Normally stains prostate carcinoma

Back 99

Racemase (p504s)

Front 100

Used to identify smooth muscle differentiation, leiomyoma and leiomyosarcoma; rhabdomyosarcoma is usually negative

Normally stains smooth muscle actin (cytoplasmic)

Back 100

α-Actin

Front 101

Used to identify muscle differentiation

Normally stains smooth, skeletal, and cardiac muscle, myoepithelial cells (cytoplasmic)

Back 101

Actin (HHF-35)

Front 102

Used to identify GIST, also seminoma, mature teratoma, and AML

Normally stains mast cells, interstitial cells of Cajal (cytoplasmic and membranous)

Back 102

c-kit

Front 103

Used to identify GIST, solitary fibrous tumor (SFT), dermatofibrosarcoma protuberans (DFSP), malignant peripheral nerve sheath tumor (MPNST), and vascular
sarcomas plus other soft tissue tumors

Normally stains fibroblasts, endothelial cells, and hematopoietic blasts (cytoplasmic and membranous)

Back 103

CD34

Front 104

Used to identify primitive neuroectodermal tumor (PNET)/Ewing’s sarcoma, lymphocytes in thymoma, plus other sarcomas and hematologic tumors. Neuroblastoma is negative

Normally stains a variety of mesenchymal cells (membranous)

Back 104

CD99 (O13)

Front 105

Used to identify muscle differentiation, including rhabdomyosarcoma, some leiomyosarcomas, and others

Normally stains intermediate fi laments in smooth, striated, and cardiac muscle (cytoplasmic)

Back 105

Desmin

Front 106

Used to identify some sarcomas (synovial sarcoma, epithelioid sarcoma) plus chordoma, meningioma, mesothelioma, perineural tumors, and plasma cell tumors

Normally stains epithelial, perineural, meningeal cells (cytoplasmic or membranous)

Back 106

EMA

Front 107

Used to identify fibrohistiocytic tumors, such as malignant fibrous histiocytoma (MFH) and dermatofibroma, giant cell tumor of tendon sheath

Normally stains fibrohistiocytic cells (cytoplasmic)

Back 107

FXIIIa and CD68

Front 108

Used to identify angiomyolipoma, clear cell sarcomas, PEComas (perivascular epithelioid cell tumor), and others; also epithelioid and metastatic melanomas

Normally stains immature melanocytes (cytoplasmic)

Back 108

HMB45

Front 109

Used to identify rhabdomyosarcoma

Normally stains regenerating, but not normal, skeletal muscle (cytoplasmic)

Back 109

Myogenin

Front 110

Used to identify cellular schwannoma, granular cell tumors, malignant peripheral nerve sheath tumor (MPNST), chondrosarcoma, melanomas (all types), astrocytoma

Normally stains Glial cells, melanocytes, dendritic and Langerhans cells, other mesenchymal cells (nuclear and cytoplasmic)

Back 110

S100

Front 111

Used as an internal control for immunoreactivity and antigen preservation (the “pan-keratin” of soft tissue)

Normally stains most mesenchymal cells (cytoplasmic), including fibroblasts, endothelium, smooth muscle

Back 111

Vimentin

Front 112

Used to identify desmoplastic small round cell tumor, also Wilms’ tumor

Normally stains a tumor suppressor gene in developing nephrons; nephrogenic rests and adult glomerular podocytes (nuclear)

Back 112

WT-1

Front 113

Used to identify medullary carcinoma of thyroid

Normally stains C cells of the thyroid (cytoplasm and extracellular material)

Back 113

Calcitonin

Front 114

Used to identify metastatic thyroid carcinoma

Normally stains thyroid follicles (cytoplasmic)

Back 114

Thyroglobulin

Front 115

Used to identify thyroid carcinoma, including follicular, papillary, and medullary; also nonsquamous carcinoma of lung (adenocarcinoma and small cell)

Normally stains a transcription factor in lung and thyroid (nuclear)

Back 115

TTF-1