Immunology - Type Ii Hs

Front 1

Which complement by profucts will activate neutros to cause inflamation and tisue injury?

Back 1

C5a and C3a

Front 2

In type II Ab mediated HS, which comlepmet componenets will opsonize cells for phagocytosis?

Back 2

C3b on an RBC or something else that is easy to engulf

Front 3

In Fc mediated inflamattion, how are cells killed by neutros, macros, and NK cells?

Back 3

these cells have receptors for IgG

Front 4

What are two processes of type II HS that do not require cell/tissue injury?

Back 4

Ab stimulates recptor without hormone

Ab inhibits binding of NT to its receptor

Front 5

What reaction exhibits a process in which IgM Abs agglutinate to RBCs, and subsequently IgM activates the complement and the MAC destroys the cells?

Back 5

Transfusion reaction

Front 6

Is there class switching in the transfusion reaction?

Back 6

NO

Front 7

WHat happens during the second pregnancy of an Rh - woman givig birth to a second Rh + baby?

Back 7

IgG Abs to Rh in the meternal circulation can cross the placenta and destry the Rh + fetal RBCs?

Front 8

What is the mechanism of RBC destruction in HDN?

Back 8

opsonization and phagocytosis

Front 9

What is Rho-Gam?

Back 9

anti-D or anti Rh injections given to protect the mother from making memory response to 2nd degree pregnanacy

Front 10

What is the Ig class of Abs made against Rh + Ags in the mother in HDN?

Back 10

IgG

Front 11

What Human Andibody Mediated Disease (HAMD) opsonizes and phagocytoses RBCs due to Rh Ags or I Ags, and causes hemolytic anemia

Back 11

AI hemolytic anemia

Front 12

What are the target antigens in ITP, that cause opsonizationa nd phagocytosis to cause bleeding?

Back 12

platelet membrane proteins gp IIb:IIIa intergin

Front 13

Can drug induced HA activate the complent syatem to cause lysis of RBCs?

Back 13

yes

Front 14

What is the name of the diease in which proteins of intercellular junctions of epidermal cells (epidermal cadherin) can be targeted by Ab mediated activation of proteases to cause disruption of intercellular adhesions and result in skin bullae?

Back 14

pemhigus vulgaris

Front 15

What are the main Ig Abs in pemphigus vulgaris?

Back 15

IgG

Front 16

What is an AI disease that fuctions primarily via IgG Abs to ultimately cause nephritis and lung hemorrhages?

Back 16

Goodpastures syndrome

Front 17

What is th emechanism of disease in goodpature's?

Back 17

comlement mediated and Fc mediated inflammation target NONcollagenous protein in basement membrane or glomeruli and alveoli

Front 18

In goodpastures, what cross reacts with alveolar BM to lead to pulmonary hemmorhhage?

Back 18

Anti-GBM Abs

Front 19

How fast does goodpastures progress?

Back 19

rapidly

Front 20

What AI disease involves strep cell wall AG cross reaction with myocardial Ag to cause macro activation an inflammation?

Back 20

Rheumatic Fever

Front 21

What is a cardianl Sx of Rheum Arthitis besides myocarditis?

Back 21

arthritis

Front 22

What is unique about the arthritis of rheumatic fever?

Back 22

moves from joint to joint

Front 23

What is the mechanism of disease in myashethia gravis?

Back 23

Ab inhibition of Ach binding and subsequent downregulaion of receptors

Front 24

What is the mechanism of graves disease?

Back 24

Ab mediated stimulation of TSH receptors

Front 25

What is the mechanism of pernicious anemia?

Back 25

neutralization of IF, which decrease absorption of B12

Front 26

What are the two types of Abs to IF?

Back 26

one blocks attachement of IF to B12

one blocks attachment of the IF-B12 complex to the Ileal recptors

Front 27

Which immune cells play a role in the second componenet of pernicious anemia?

Back 27

pathogenic CD4+ T cells

Front 28

What kind of immunofluorescent pattern is exhibited in Tyepe II HS?

Back 28

LINEAR

Front 29

What are the uses for the direct coombs test?

Back 29

determining autoimune hemolytic anemia

and

the presence of maternal anti-Rh Ab on newborns's RBCs

Front 30

What are the uses for the INdirect coombs test?

Back 30

testing of blood transfusion recipients for preformed Ab

and

A rise in titer in mother with potential to make anti-Rh Ab

Front 31

What non-immunosupressive treatment is used to treat diseases such as MG and GP syndrome?

Back 31

plasmapheresis, which is when blood is pumped against a permeabe membrane which allows Ig to pass through

Front 32

What type of HS involves IgG or IgM Abs that react with soluble antigens ro form immune complexes that are deposited in tissues?

Back 32

Type III sensitivity