Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
42 Cards in this Set
- Front
- Back
|
What is the name of the chain found in the heavy section of an IgG?
|
γ
|
|
|
What is the name of the chain found in the light section of an IgG?
|
λ or κ
NEVER both |
|
|
What are the domains found on heavy chains of IgG?
|
1 variable, 3 constant
|
|
|
What are the domains found on a light chain of IgG?
|
1 variable, 1 constant
|
|
|
What is the site of AG binding on a heavy IgG chain?
|
Variable
|
|
|
What is the site of AG binding on a light IgG chain?
|
Variable
|
|
|
What is the site of function determination on a heavy IgG chain?
|
Constant domains
|
|
|
What is the site of function determination on a light IgG chain?
|
None present
|
|
|
Be sure to review the chain layout on Pg. 50.
Know what each portion of the chain is called. |
Be sure to review the chain layout on Pg. 50.
Know what each portion of the chain is called. |
|
|
Two main regions associated with the IgG anti-body
|
Fab
Fc |
|
|
Which domains are present in IgG Fab?
|
Vh, Ch1, VL, CL
|
|
|
Which domains are present in Fc?
|
Ch2, Ch3
|
|
|
Which domain is duplicated?
|
Fab
|
|
|
Which domain is responsible for binding AGs?
|
Fab
|
|
|
Which domain determines function?
|
Fc
|
|
|
Which ABs have J-chains?
|
IgM
IgA |
|
|
Order of [plasma] of ABs from most to least.
|
IgG
IgM IgA IgE |
|
|
What is IgG synthesized in?
|
Systemic immune system
|
|
|
What is IgM synthesized in?
|
Systemic immune system
MALT |
|
|
What is IgA synthesized in?
|
MALT
|
|
|
What is IgE synthesized in?
|
MALT
|
|
|
Location of IgG
|
Plasma
Tissue fluids |
|
|
Location of IgM
|
Plasma
|
|
|
Location of IgA
|
Secretions
Plasma |
|
|
Location of IgE
|
Mast cells
|
|
|
4 functions of IgG
|
BCR
Neutralization Complement activation Opsonization |
|
|
3 functions of IgM
|
BCR
Neutralization Complement activation |
|
|
2 functions of IgA
|
BCR
Neutralization |
|
|
2 functions of IgE
|
BCR
Mast cell activation |
|
|
How does neutralization take place?
|
ABs bind to virus capsule to prevent it binding to cell body.
|
|
|
Which AB is best at Complement activation?
|
IgM >> IgG
|
|
|
What does the complement C3a do?
|
Activates mast cells
|
|
|
What does the complement C3b do?
|
Opsonization
Increase AB production |
|
|
What does the complement C5a do?
|
Activates mast cells
Chemotaxis |
|
|
Which antibodies are involved in Neutralization?
|
IgG, IgM, IgA equally
|
|
|
Which AB is best at opsonization?
|
IgM
|
|
|
Which AB is primarily responsible for ADCC?
|
IgG
(IgE to a lesser degree) |
|
|
Which AB activates mast cells?
|
IgE
|
|
|
What protects IgA from enzymatic digestion?
|
Secretory component
(portion of receptor left bound to IgA) |
|
|
How does neutralization of toxins work?
|
Prevents binding of toxin to cell receptors
|
|
|
How does neutralization of bacteria work?
|
Inhibits bacteria attachment to epithelial cells
|
|
|
What is ADCC used for?
|
Helps kill pathogens that are too large to be phagocytosed, such as parasite larvae.
|
