Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
14 Cards in this Set
- Front
- Back
|
Cyclosporine
|
MOA: bind cylophilin -> complex binds calcineurin causing inhibition -> no IL-2 or IL-2 receptor produced
Tox: inc risk of viral infxn and lymphoma; nephrotoxic (prevent w/ mannitol |
|
|
Glucocorticoids
|
Inhibit integrins = leukocytosis
Bind NF-kB downregulate -> dec IL-2 and IL-2 receptors |
|
|
Molecular biology T cell activation
|
T cell: MHC class II and TCR; B7(CD80/86) and CD28
3 pathways carry through CD3 1.) calcium-calcineurin 2.) RAS-MAP Kinase 3.) NF-kB make IL2 and receptor these bind one another -> mTOR -> cyclin |
|
|
Tacrolimus
|
(FD506)
MOA: Binds FK-binding protiein -> complex binds calcineurin -> inhibits signal transduction and IL-2 production Toxicity: Nephrotoxicity, peripheral neuropathy, HTN, pleural effusion, hyperglycemia |
|
|
Sirolimus
|
- rapamycin
MOA: inhibits mTOR. therefore inhibits Tcell response to IL-2 Use: kidney transplant (cyclosporine + sirolimus + glucocorticoid) Tox: Hyperlipidemia, thrombocytopenia, leukopenia |
|
|
Daclizumab
|
monoclonal Ab to IL-2 receptors on activated T-cells
|
|
|
Muromonab
|
Muromonab-CD3 (OKT3)
- MOA: monoclonal Ab binds CD3 (epsilon chain) on T cell surface -> block signal transduction - Cytokine release syndrome (after 1st dose); hypersensitivity Rxn |
|
|
Azathioprine
|
MOA: antimetabolite, converted to 6-mercaptopurine; interrupts nucleic acid synthesis and toxic to proliferating T cells
USE: kidney transplant and autoimmune Tox: BM suppression; Mercaptopurine is metabolized by xanthine oxidase therefore toxic effects inc w/ allopurinol |
|
|
Aldesleukin:
|
Aldesleukin: IL-2; RCC, metastatic melanoma
|
|
|
Filgrastim
Sargamostim Oprelvekin thrombopoietin |
Filgrastim = G-CSF; BM recovery
Sargamostim = GM-CSF; BM recovery Oprelvekin = IL-11; thombocytopenia Thrombopoietin = thrombocytopenia |
|
|
Infliximab
|
TNF-alpha antibody
Use: PAIR = psoriasis, chrons Rheumatoid arthritis |
|
|
Adalimumab
|
TNF-a antibody
RA, Chron's Psoriartic arthritis |
|
|
Abciximab
|
Glycoprotein IIb/IIIa antibody
prevent cardiac ischemia in unstable angina and in pts tx w/ percutaneous coronary intervention |
|
|
Rituximab
|
CD20 Ab
B-Cell Non-Hodgkin's Lymphoma |
