Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
33 Cards in this Set
- Front
- Back
|
4 broad categories of immunodeficiency
|
1. neutrophil disorders
2. antibody deficiency 3. complement deficiency 4. T-cell dysfunction |
|
|
What is the immune defect of "Digeorge's syndrome"
Susceptibility? |
variable # of B- and T-cells
Susceptibility: general |
|
|
What is the immune defect of "MHC-I deficiency"
Susceptibility? |
no CD8 cells
Susceptibility: lung inflammation |
|
|
What is the immune defect of "MHC-II deficiency"
Susceptibility? |
no CD4 cells
Susceptibility: general |
|
|
What is the immune defect of "Wiskott-Aldrich syndrome"
Susceptibility? |
defective anti-polysaccharide Ab
Susceptibility: encapsulated extracellular bacteria |
|
|
What is the immune defect of "X-linked agamma-globulinemia"
Susceptibility? |
no B cells
Susceptibility: extracellular bacteria, viruses |
|
|
What is the immune defect of "X-linked hyper-IgM syndrome"
Susceptibility? |
no isotype switching
Susceptibility: extracellular bacteria |
|
|
What is the immune defect of "common variable immunodeficiency"
Susceptibility? |
defective IgA and IgG production
Susceptibility: extracellular bacteria |
|
|
What is the immune defect of "selective IgA"
Susceptibility? |
no IgA synth
Susceptibility: respiratory infection |
|
|
What is the immune defect of "complement deficiency"
Susceptibility? |
loss of complement components
Susceptibility: extracellular bacteria |
|
|
What is the immune defect of "ataxia telangiectasia"
Susceptibility? |
reduced T-cells
Susceptibility: respiratory infection |
|
|
What is the immune defect of "Bloom's syndrome"
Susceptibility? |
reduced T-cells
Susceptibility: respiratory infection |
|
|
what is the result of "leukocyte adhesion deficiency"
|
widespread pyogenic bacterial infections
|
|
|
what is the result of "Granulomatous disease"
|
granulomas, infection
|
|
|
what is the result of "G6PD deficiency"
|
defective 'respiratory burst', infection
|
|
|
what is the result of "Myeloperoxidase deficiency"
|
defective 'intracellular killing', infection
|
|
|
What is the immune defect of "NK defect"
Susceptibility? |
loss of NK function
Susceptibility: herpes virus |
|
|
where is HIV-2 found? HIV-1?
what is the difference? |
HIV-2 found in Africa, HIV-1 everywhere else
HIV-2 has lower mortality rate HIV-1 more closely related to SIV |
|
|
how does HIV-1 attach and enter into CD4 cells? (3 steps)
|
1. viral surface protein gp120 attaches to CD4 of T-cell
2. conformation change in gp120, then it binds to CCR5 3. HIV envelope fuses with cell membrane via gp41 |
|
|
what is a "provirus"
|
the viral genome inserted into the T-cell genome. it lays dormant until next T-cell activation
|
|
|
each HIV-infected cell can produce ____ (#) new virions before it dies
|
250
|
|
|
the AIDS drug, AZT, is what type of drug?
|
reverse transcriptase inhibitor
|
|
|
where is HIV-2 found? HIV-1?
what is the difference? |
HIV-2 found in Africa, HIV-1 everywhere else
HIV-2 has lower mortality rate HIV-1 more closely related to SIV |
|
|
how does HIV-1 attach and enter into CD4 cells? (3 steps)
|
1. viral surface protein gp120 attaches to CD4 of T-cell
2. conformation change in gp120, then it binds to CCR5 3. HIV envelope fuses with cell membrane via gp41 |
|
|
what is a "provirus"
|
the viral genome inserted into the T-cell genome. it lays dormant until next T-cell activation
|
|
|
each HIV-infected cell can produce ____ (#) new virions before it dies
|
250
|
|
|
the AIDS drug, AZT, is what type of drug?
|
reverse transcriptase inhibitor
|
|
|
what is H.A.A.R.T.
|
Highly Active Anti-Retroviral Therapy
the "cocktail" |
|
|
what are the three stages of tumor progression?
|
Immune surveillance
immunoediting escape |
|
|
what is immune surveillance?
|
the first stage of tumor progress when the tumor cells are kept in check by immune system
|
|
|
what is the "immunoediting stage"
|
the tumor cells, over time, develop in various different forms to evade the immune system
|
|
|
what is the "escape phase"
|
when one of the tumor cell variants is able to escape the killing mechanisms of the immune system
|
|
|
what is the first anti-cancer vaccine?
|
Gardisil
|
