Immunology

Front 1

Attack intracellular pathogens

 Cellular immunity

Back 1

T lymphocytes

Front 2

Recognize and clear extracellular material

 Humoral immunity

Back 2

B lymphocytes

Front 3

Activated B cell

 Produces antibody

Back 3

plasma cell

Front 4

Manufacture antibody that specifically

recognizes antigen

Back 4

B cell

Front 5

Recognize and interact with antigen

 Produce cytokines

 CD4

Back 5

T helper

Front 6

Clear viral infected, tumor, and foreign tissue graft cells

 CD8

Back 6

T cytotoxic

Front 7

any substance (usually

foreign) that combines with an antibody

or binds to a T cell

Back 7

Antigen

Front 8

antigen in its role of

eliciting an immune response

Back 8

Immunogen

Front 9

Responsible for specificity

 Recognized by a specific antibody or

receptor

Back 9

Epitope or antigenic determinants

Front 10

Proteins composed of four polypeptide

chains joined by disulfide bonds

Back 10

antibodies

Front 11

5 classes of Igs

Back 11

IgG, IgA, IgM, IgD, and IgE

Front 12

Heavy chain determines class

Back 12

antibodies

Front 13

Imparts flexibility

 Allows each ag-binding site to function

independently

Back 13

hinge region

Front 14

 Idiotypes



Back 14

Variable region – antigen binding

Front 15

Binds to antigenic

determinant

Back 15

Fragment, antigenbinding

(Fab)

Front 16

Constant domain

Back 16

Fragment,

crystallizable (Fc)

Front 17

Parts of the antibody that are common

to a host.

Back 17

Allotype

Front 18

Ig class; determined by the heavy

chains

Back 18

Isotype

Front 19

Specific to the antigen stimulating the

response.

Back 19

Idiotype

Front 20

First antibody produced in immune

response

Back 20

IgM

Front 21

Five basic Ig molecules held together

with a joining (J) chain

 Pentamer

 10 potential ag-binding sites

Back 21

IgM

Front 22

Direct agglutinate

 Efficient in complement (C’) activation

Back 22

IgM

Front 23

2 gamma heavy chains, two light chains

 Monomer

 Divalent

Back 23

IgG

Front 24

Inefficient in direct agglutination

 2 needed to activate C’

Back 24

IgG

Front 25

80 % of total serum

concentration

Back 25

IgG

Front 26

serum half life 23 days

Back 26

IgG

Front 27

serum half life 5-6 days

Back 27

IgM

Front 28

very efficient at Activation of the

classical pathway of

complement

Back 28

IgM

Front 29

Optimal temperature

for reaction in

immunohematologic

tests room temp or below

Back 29

IgM

Front 30

Optimal temperature

for reaction in

immunohematologic

tests 37

Back 30

IgG

Front 31

Agglutination upon

immediate spin

Back 31

IgM

Front 32

Agglutination in antiglobulin

tests

Back 32

IgG

Front 33

Predominant in secretions

 First line of defense - prevents foreign agents from entering body

 Does not bind complement by classical pathway, but can activate alternate

pathway

Back 33

IgA

Front 34

First Ig class produced in primary immune response

 Found on surface of unstimulated, resting B lymphocytes

Back 34

IgM

Front 35

Exists as monomer on unstimulated, resting B lymphocytes

 No blood group antibodies known to be ___

Back 35

IgD

Front 36

Exists as monomer bound to basophils or mast cells

 Binding of antigen triggers release of histamine (allergic reactions).

 Involved in hypersensitivity - anaphylaxis, parasitic infections

Back 36

IgE

Front 37

All cross placenta

Back 37

IgG

Front 38

30+ serum proteins, made by liver cells

Back 38

complement

Front 39

amorph allele

Back 39

ALLELE of a gene that appears to code for no detectable product

Front 40

Whichtype of oligosaccharide chain is typically found in secretions?

Back 40

Type 1 chains

Front 41

type 1 chains found in secretions have what linkage?

Back 41

β1→3 linkage

Front 42

type 2 chains found on red cells have what linkage?

Back 42

β1→4 linkage

Front 43

Hh and Se (secretor) are on chromosome

Back 43

19

Front 44

what gene produces a glycosyltransferase that acts on type 2 chains - H ag on RBCs

Back 44

H

Front 45

what gene produces glycosyltransferase that acts on type 1 chains - H ag in secretions

Back 45

Se

Front 46

converts both branched and unbranched H antigens

Back 46

A1

Front 47

converts only unbranched H antigen

Back 47

A2

Front 48

dolichos biflorus is a source of

Back 48

Anti A1 lectin from seed extracts

Front 49

anti h lectin

Back 49

ulex europaeus

Front 50

Hh and Se (secretor) are on chromosome

Back 50

19

Front 51

produces a glycosyltransferase that acts

on type 2 chains

Back 51

H

Front 52

produces a glycosyltransferase that acts

on type 1 chains

Back 52

Se

Front 53

B13 linkage

Back 53

Type 1 – Body Fluids and

Secretions

Front 54

B14 linkage

Back 54

Type 2 – Red Blood Cells

(Body Fluids and Secretions)

Front 55

Produces -2-L-fucosyltransferase

Back 55

H gene

Front 56

Produces -3-Nacetylgalactosaminyltransferase

Back 56

A gene

Front 57

Produces -3-galactoslytransferase

Back 57

B gene

Front 58

Adds N-Acetylgalactosamine to H ag (GalNAc)

Back 58

A gene

Front 59

Adds D-galactose to H ag (Gal)

Back 59

B gene

Front 60

immunodominant

sugars

N-acetylgalactosamine (GalNAc)

Back 60

A

Front 61

immunodominant

sugars

D-Galactose

Back 61

B

Front 62

% population has Se gene (secretor)

Back 62

78

Front 63

another source of

Anti-A1 (lectin from seed extracts)

Back 63

Dolichos biflorus

Front 64

Anti-H lectin

Back 64

Ulex europaeus