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29 Cards in this Set

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IgG
37*C
Crosses placenta
RBC
IgM
4-22*C
NRBC
Zeta potential
-difference in electrostatic potential between inner and outer layers of ionic cloud that surrounds red cells in solution
-enzs. removes salsilic acid
Albumin potentiators
Increases dielectric constant
-Reduces zeta potential
LISS
Low Ionic Strength Solution
-Decreases ionic strength of reaction medium
-Reduces zeta potential
Increases uptake of antibody molecules
-Shortens incubation period
PEG
Polyethylene Glycol
DOSAGE EFFECT
A phenomenon whereby an antibody reacts more strongly with a red cell carrying a double dose than with a red cell carrying a single dose of an antigen
Location of ABO alleles
Chromosone 9
Codominant
A and B
amorph
o
Distribution O
W:45%
B:49%
A:43%
Distribution A
W:41%
B:27%
A:27%
Distribution B
W:10%
B:19%
A:25%
Distribution A,B
W:4%
B:4%
A:5%
ABO and H genes code for_____
glycosyltransferases enzymes
H gene
-Chromosome 19
-affects the formation of ABO ag
-Fucosyl= Transferase
-fucose= sugar
-must inharit H
Bombay phenotype
No H gene inharited- hh(Oh)
A gene
N-acetylgalactosaminyl= trans
GALNAC= sugar
B gene
-galactosyl= transferase
-galactose= sugar
O gene
Just the H substances
-nothing extra
Type 1 precursor
-found in secretions, body fluids, plasma
-beta 1--->3 linkage
-glycoproteins
Type 2 precursor
-found on RBCs
-beta 1--->4 linkage
-glycolipids
Secretors
H, A, B water soluble substances found in saliva
-78%
controlled by Se gene (SeSe or Sese)
-codes for the production of fucosyltransferase
-utilizes Type 1 precursors
non-secretors
-homozygous for se se
-do not secrete ABH substances
A1 cells
-80%
-Reacts w/ anti-A and A1
-attaches Galnac to branched chains
-Low/High level of H/A
A2 cells
-20%
-Reacts w/ only anti-A
-attaches Galnac to stright chains
-High/Low level H/A
Anti-A1
1-8% of A2 have anti-A1
22-35% of A2B have anti-A1
-Dilichous Biflorous= source
Anti-H
-produced by bombay
-ulex europaeus
Wharton's Jelly
-Viscous mucopolysaccharide
-Cord blood
-Spontaneous rouleaux
-Wash cord cells 6-8 times with saline