Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
25 Cards in this Set
- Front
- Back
|
Primary Stage of Syphilis: how long does it last? How painful is it? |
- 1 week to 3 months after exposure - Chancre at site of entry - 4-6 weeks heals by itself - painless; goes away spontaneously |
|
|
Secondary Syphilis |
- 2-8 weeks, up to 6 months - Development of rash/ more widespread lesions of skin & mucous membrane -- Lesions contain large # of spirochetes - Highly Contagious - Resolves 2-6 weeks, even w/o therapy - Enlarhed lymph nodes, fever, loss of weight, sore throat, headached, stiffness in head/neck, light sensitivity |
|
|
Latent Stage Syphilis |
- Follows secondary syphilis - No symptoms - Only diagnosed serologically |
|
|
Tertiary Stage Syphilis |
- Follows untreated latent stage -- 1/2 develop into tertiary - occurs as early as 1 yr after exposure, lasts for decades - Gummas- Chronic festering pockets of inflammatory molecules and cells --Everywhere (bones, skin, tissues) - Affects anatomy (grotesque deformaties) - Affects ascending arota -- aneurysms, inflammation, heart failure |
|
|
Neurosyphilis |
- Changes in behavior and personality, changes in emotional reactions, psychotic symptoms - Hyper-reactive reflexes - Irregularities in function of pupils - Gradual degradation of sensory neurons |
|
|
RPR: Syphilis |
Mostly used nontreponemal serologic test, determines the presence of regain Abs |
|
|
VRDL: Syphilis (what type of Abs does it measure) |
Measures IgM & IgG Abs to lipoidal tissue |
|
|
FTA-ABS: Syphilis |
Confirms a pos nontreponemal test |
|
|
Order these screening test by the order for syphilis testing: RPR Non-specific VDRL FTA-ABS |
Non-specific VDRL RPR FTA-ABS |
|
|
What cells does EBV target? |
B-Lymphocytes |
|
|
What Are EBV's screening tests? |
Screening - Paul-Bunnell Screening test (Presumptive test) -- Add sheep RBCs to serum -- 1:56 titer indicates IM, serum sickness, or Forssman Abs - Davidsohn Differential -- 2 step process. Add guinea pig kidney to absorb non-mono Abs then add Horse/sheep RBC |
|
|
Confirmatory: EBV |
PCR Anti-VCA -- IgM= acute Infection -- IgG= Past Exposure |
|
|
Primary types of Hepatitis |
A, B, C, D, E |
|
|
EBV- Early Antigen (EA-?) |
- EA-D: early Ag= acute infection -- EA-D Abs: seen in IM and NPC - EA-R: early Ag= acute infection -- EA-R Abs: seen in Burkitt's Lymphoma - Diffuse/ restricted= IM staining |
|
|
What Liver enzymes are elevated in hepatitis? |
ALT AST |
|
|
What are the characteristics of Hepatitis A? (Transmission, detectable in) |
- Not Bloodborne. Fecal Oral route, contaminated shellfish - P2P - Shed in feces for up to 4 weeks - Highest in acute phase stool |
|
|
Hepatitis A diagnositic eval |
EIA: if pos - Hep A Abs (IgM Ab) |
|
|
Fulminant Hepatitis |
Rare Liver destruction Bleeding diasorders Coma Often Fatal |
|
|
Hepatitis B: Lab diagnosis (Ags and Abs) |
- Hep B surface Ag (HBsAg) - Hep B core Ab, total, IgM (anti-HBc) - Hep B surface Ab (anti-HBs) |
|
|
What is required for a Hepatitis D infection? |
Patient had to be infected w/ Hepatitis B |
|
|
How is Hepatitis C transmitted? |
Multiple sex partners Surgery w/ transfusion before '92 Tatoo Drug inections |
|
|
How long is Hepatitis acute phase infection? |
6-7 weeks |
|
|
How is Hepatitis E transmitted? |
Fecal-oral route |
|
|
Hepatitis E symptoms |
Mild infection; except in preg women, can cause developmental delays in 10-20% of cases |
|
|
Typical acute panel for Hepatitis |
- IgM anti-HaV - IgM anti-HBcAg - HBsAg - Anti-HCV |
