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27 Cards in this Set
- Front
- Back
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CD1
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Glycolipids, not MHC-encoded
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CR4
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Also alphaX, beta2, CD11c/Cd18
On DC, macrophage, neutrophils |
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Artemis
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NHEJ factor, hairpin coding end defect
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Src family
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SH2, SH3
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STAT
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N-term, coiled coil, DNA binding domain, SH2, TAD (transcriptional activation domain)
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IL-10
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Jak1, Tyk2, Stat3
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IL-2
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Jak1, Jak3, Stat5
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IFN-gamma
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Jak1, Jak2, Stat1
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IL-3
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Jak2, Stat5
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Qa-1, HLA-E
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Self-Class I signal peptides
Major ligand for CD94/NKG2A |
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LFA-1
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Also alphaL, beta2, CDlla/CD18
On T cells, macrophages, neutrophils, DC |
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Syk KO
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Embryonic lethal
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Tec family
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PH, TH, SH2, SH3
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IL-12
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Jak2, Tyk2, Stat4
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IL-6
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Jak1, Stat3
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IL-4
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Jak1, Jak3, Stat6
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IL-13
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Jak2, Tyk2
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M3
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Mouse, N-formylated peptides
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HFE
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Transferrin receptor
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Mac-1
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Also alphaM, beta2, CD11a/CD18
On neutrophils, monocytes, macrophage |
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Tonegawa
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1976, somatic rearrangement
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B-1 B cells
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CD5 on surface, make IgM natural antibodies, from fetal liver, small repertoire as they use the V closest to D, don't need T cell help, no somatic hypermutuation, no TdT
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JAK
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FERM, SH2, pseudokinase, kinase
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Type 1 IFNs
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Tyk2, Jak1, Stat1, Stat2
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IL-15
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Jak1, Jak3, Stat5
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IL-5
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Jak2, Stat5
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IL-7
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Jak1, Jak3, Stat5
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