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86 Cards in this Set
- Front
- Back
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IL-1
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secreted by macrophages;
causes acute inflammation; induces chemokine production to recruit leukocytes; activates endothelium to express adhesion molecules; an endogenous pyrogen |
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IL-2
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secreted by Th cells
stimulates growth of Th and Tc |
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IL-3
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secreted by activated T cells;
supports growth and differentiation of bone marrow stem cells; function similar to GM-CSF |
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IL-4
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secreted by Th2 cells;
promotes growth of B cells; enhances class switching to IgE and IgG |
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IL-5
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secreted by Th2 cells;
promotes differentiation of B cells; enhances class switching to IgA; stimulates production and activation of eosinophils |
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IL-6
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secreted by Th cells and macrophages;
stimulates production of acute-phase reactants and immunoglobulins |
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IL-8
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secreted by macrophages
major chemotactic factor for neutrophils |
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IL-10
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secreted by regulatory T cells
inhibits actions of activated T cells |
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IL-12
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secreted by B cells and macrophages;
activates NK and Th1 cells |
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INF-g
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secreted by Th1 cells
stimulates macrophages |
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TNF
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secreted by macrophages
medicates septic shock causes leukocyte recruitment, vascular leak |
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CD28
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Th cells
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CD40L
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Th cells
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TCR, CD3
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Th and Tc cells
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receptor for EBV
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CD21
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B cell surface proteins
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IgM
B7 CD19 CD20 CD21 CD40 MHC II |
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B7
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B cells
macrophages |
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CD40
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B cells
macrophages |
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CD14
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macrophages
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macrophage cell surface proteins
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MHC II
B7 CD40 CD14 Fc and C3b receptors |
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NK cell surface proteins
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receptors for MHC I
CD16 CD56 |
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CD16
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NK cells
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binds Fc of IgG
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CD16 of NK cells
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CD56
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NK cells
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pernicious anemia
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type II hypersensitivity
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idiopathic thrombocytopenic purpura
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type II hypersensitivity
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erythroblastosis fetalis
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type II hypersensitivity
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rheumatic fever
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type II hypersensitivity
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bullous pemphigoid
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type II hypersensitivity
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pemphigus vulgaris
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type II hypersensitivity
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myasthenia gravis
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type II hypersensitivity
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rheumatoid arthritis
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type III hypersensitivity
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polyarteritis nodosum
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type III hypersensitivity
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serum sickness
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type III hypersensitivity
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hypersensitivity pneumonitisi (eg farmer's lung)
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type III hypersensitivity
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type I diabetes mellitus
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type IV hypersensitivity
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multiple sclerosis
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type IV hypersensitivity
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guillain-barre syndrome
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type IV hypersensitivity
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hashimoto's thyroiditis
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type IV hypersensitivity
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graft-versus-host disease
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type IV hypersensitivity
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contact dermatitis
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type IV hypersensitivity
(eg poison ivy, nickel allergy) |
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antinuclear antibodies (ANA)
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SLE
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anti-dsDNA
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specific for SLE
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anti-Smith
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specific for SLE
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anti-IgG
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rheumatoid arthritis
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antihistone
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drug-induced lupus
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anticentromere
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scleroderma (CREST)
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anti-Scl-70
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scleroderma (diffuse)
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antimitochondrial
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primary biliary cirrhosis
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antigliadin
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celiac disease
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antiendomysial
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celiac disease
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anti-basement membrane
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goodpasture's syndrome
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anti-desmoglein
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pemphigus vulgaris
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antimicrosomal
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hashimoto's thyroiditis
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antithyroglobulin
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hashimoto's thyroiditis
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anti-Jo-1
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polymyositis
dermatomyositis |
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anti-SS-A (anti-Ro)
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sjorgen's syndrome
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anti-SS-B (anti-La)
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sjorgen's syndrome
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anti-U1 RNP (ribonucleoprotein)
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mixed connective tissue disease
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anti-smooth muscle
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autoimmune hepatitis
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anti-glutamate decarboxylase
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type 1 diabetes mellitus
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c-ANCA
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wegener's granulomatosis
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p-ANCA
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other vasculitides (not wegeners)
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HLA-A3
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hemochromatosis
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HLA-B27
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psoriasis
ankylosing spondylitis inflammatory bowel disease reiter's syndrome |
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HLA-B8
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graves' disease
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HLA-DR2
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multiple sclerosis
hay fever SLE goodpasture's |
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HLA-DR3
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diabetes mellitus type 1
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HLA-DR4
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rheumatoid arthritis
diabetes mellitus type 1 |
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HLA-DR5
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pernicious anemia
hashimoto's thyroiditis |
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HLA-DR7
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steroid-responsive nephrotic syndrome
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bruton's aggamaglobulinemia
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decreased production of b cells;
XR defect in tyrosine kinase gene (BTK); low levels of all immunoglobulins; recurrent bacterial infections after 6 months |
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thymic aplasia (digeorge)
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decreased t cell production;
22q11 deletion; failure of development of 3rd and 4th pharyngeal pouches; tetany due to hypocalcemia; recurrent viral and fungal infections; congenital defects of heart and great vessels |
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SCID
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decreased production of b and t cells - defect in early stem cell differentiation;
recurrent viral, bacterial, fungal, and protozoal infections; many causes (no MHC II, defective IL-2 receptors, ADA def) |
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most common form of SCID and inheritance
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defective IL-2 receptors
X-linked |
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IL-12 receptor deficiency
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decreased activation of t cells;
disseminated mycobacterial infections; decreased Th1 response |
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hyper-IgM syndrome
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decreased activation of b cells;
defect in CD40L of t cells - inability to class switch; severe pyogenic infections; high levels of IgM; very low levels of IgG, IgA, IgE |
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wiskott-aldrich syndrome
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decreased activation of b cells;
X-linked defect in ability to mount IgM response to capsular polysaccharides of bacteria; elevated IgE, IgA; low IgM; triad: pyogenic infections, thrombocytopenic purpura, eczema |
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job's syndrome
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decreased activation of neutrophils;
failure of IFN-g production by Th; neutrophils fail to respond to chemotactic stimuli; coarse facies, cold staph abscesses, retained primary teeth, increased IgE, derm problems |
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leukocyte adhesion deficiency
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phagocytic cell deficiency;
defect in LFA-1 integrin (CD18); recurrent bacterial infections, absent pus formation, neutrophilia; delayed separation of umbilicus |
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chediak-higashi
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phagocytic cell deficiency;
AR defect in microtubular function and lysosomal emptying; recurrent pyogenic infections by staph, strep; partial albinism; peripheral neuropathy |
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chronic granulomatous disease
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phagocytic cell deficiency;
X-linked lack of NADPH oxidase activity or similar enzymes; marked susceptibiliaty to opportunistic infections (s. aureus, e. coli, aspergillus [catalase(+)]); confirm with negative nitroblue tetrazolium dye reduction test |
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chronic mucocutaneous candidiasis
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idiopathic dysfunction of t cells;
dysfunction specific to candida; skin and mucous membrane candida infections |
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selective immunoglobulin deficiency
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idiopathic dysfunction of b cells;
deficiency in specific class of immunoglobulin - possibly due to defect in isotype switching; selective IgA deficiency is mc; sinus and lung infections; mild allergies and diarrhea; anaphylaxis upon exposure to blood products containing IgA |
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ataxia telangiectasia
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idiopathic dysfunction of b cells;
AR defect in DNa repair enzymes with associated IgA deficiency; cerebellar problems and spider angiomas; repeated sinopulmonary infections; increased risk of cancer |
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common variable immunodeficiency (CVID)
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idiopathic dysfunction of b cells;
normal numbers of circulating b cells; decreased plasma cells, IgG; can be acquired in 20s-30s; increased risk of autoimmune disease and lymphoma |
